BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Journal of Neuroscience

Volumn 25, Issue 50, 2005, Pages 11693-11709

  Laird, Fiona M ^a   Cai, Huaibin ^b   Savonenko, Alena V ^a   Farah, Mohamed H ^a   He, Kaiwen ^c   Melnikova, Tatyana ^a   Wen, Hongjin ^a   Chiang, Hsueh Cheng ^a   Xu, Guilian ^a,d   Koliatsos, Vassilis E ^a   Borchelt, David R ^a,d   Price, Donald L ^a   Lee, Hey Kyoung ^c   Wong, Philip C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Bldg 142   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

A amyloidosis; Alzheimer's; BACE1 null mice; Cognition; RNAi; Selective vulnerability; Synaptic plasticity

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SITE APP CLEAVING ENZYME 1; BETA SITE APP CLEAVING ENZYME 2; UNCLASSIFIED DRUG;

AGING; AMNESIA; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMOTION; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE SILENCING; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RNA INTERFERENCE; SYNAPSE; TASK PERFORMANCE; TRANSGENE;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; COGNITION; EMOTIONS; ENDOPEPTIDASES; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; SYNAPTIC TRANSMISSION;

EID: 30444440132     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2766-05.2005     Document Type: Article

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