-
1
-
-
0036315509
-
Neuropsychiatric symptoms in the dementias
-
Assal, F. & Cummings, J. L. Neuropsychiatric symptoms in the dementias. Curr. Opin. Neurol. 15, 445-450 (2002).
-
(2002)
Curr. Opin. Neurol
, vol.15
, pp. 445-450
-
-
Assal, F.1
Cummings, J.L.2
-
2
-
-
0141761520
-
Seizures in elderly patients with dementia: Epidemiology and management
-
Mendez, M. & Lim, G. Seizures in elderly patients with dementia: epidemiology and management. Drugs Aging 20, 791-803 (2003).
-
(2003)
Drugs Aging
, vol.20
, pp. 791-803
-
-
Mendez, M.1
Lim, G.2
-
3
-
-
0029914384
-
Dementia and adult-onset unprovoked seizures
-
Hesdorffer, D. C., Hauser, W. A., Annegers, J. F., Kokmen, E. & Rocca, W. A. Dementia and adult-onset unprovoked seizures. Neurology 46, 727-730 (1996).
-
(1996)
Neurology
, vol.46
, pp. 727-730
-
-
Hesdorffer, D.C.1
Hauser, W.A.2
Annegers, J.F.3
Kokmen, E.4
Rocca, W.A.5
-
4
-
-
0022531202
-
Seizures and myoclonus in patients with Alzheimer's disease
-
Hauser, W. A., Morris, M. L., Heston, L. L. & Anderson, V. E. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 36, 1226-1230 (1986).
-
(1986)
Neurology
, vol.36
, pp. 1226-1230
-
-
Hauser, W.A.1
Morris, M.L.2
Heston, L.L.3
Anderson, V.E.4
-
5
-
-
32844465332
-
Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene
-
Larner, A. J. & Doran, M. Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene. J. Neurol. 253, 139-158 (2006).
-
(2006)
J. Neurol
, vol.253
, pp. 139-158
-
-
Larner, A.J.1
Doran, M.2
-
6
-
-
0035139342
-
Sodium channel β subunits: Anything but auxiliary
-
Isom, L. L. Sodium channel β subunits: Anything but auxiliary. Neuroscientist 7, 42-54 (2001).
-
(2001)
Neuroscientist
, vol.7
, pp. 42-54
-
-
Isom, L.L.1
-
7
-
-
0036134038
-
Molecular mechanisms of gating and drug block of sodium channels
-
Catterall, W. A. Molecular mechanisms of gating and drug block of sodium channels. Novartis Found. Symp. 241, 206-18 (2002).
-
(2002)
Novartis Found. Symp
, vol.241
, pp. 206-218
-
-
Catterall, W.A.1
-
8
-
-
0033694833
-
From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
-
Catterall, W. A. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels. Neuron 26, 13-25 (2000).
-
(2000)
Neuron
, vol.26
, pp. 13-25
-
-
Catterall, W.A.1
-
9
-
-
0034646634
-
Sodium channel β subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact
-
Malhotra, J. D., Kazen-Gillespie, K., Hortsch, M. & Isom, L. L. Sodium channel β subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. J. Biol. Chem. 275, 11383-11388 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 11383-11388
-
-
Malhotra, J.D.1
Kazen-Gillespie, K.2
Hortsch, M.3
Isom, L.L.4
-
10
-
-
10944261324
-
Sodium channel β 1 subunits promote neurite outgrowth in cerebellar granule neurons
-
Davis, T. H., Chen, C. & Isom, L. L. Sodium channel β 1 subunits promote neurite outgrowth in cerebellar granule neurons. J. Biol. Chem. 279, 51424-51432 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 51424-51432
-
-
Davis, T.H.1
Chen, C.2
Isom, L.L.3
-
11
-
-
0037168659
-
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β 2-subunits
-
Chen, C. et al. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β 2-subunits. Proc. Natl Acad. Sci. USA 99, 17072-17077 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 17072-17077
-
-
Chen, C.1
-
12
-
-
33747079860
-
Sodium channel β2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain
-
Lopez-Santiago, L. F. et al. Sodium channel β2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J. Neurosci. 26, 7984-7994 (2006).
-
(2006)
J. Neurosci
, vol.26
, pp. 7984-7994
-
-
Lopez-Santiago, L.F.1
-
13
-
-
0022555877
-
Molecular properties of voltage-sensitive sodium channels
-
Catterall, W. A. Molecular properties of voltage-sensitive sodium channels. Annu. Rev. Biochem. 55, 953-985 (1986).
-
(1986)
Annu. Rev. Biochem
, vol.55
, pp. 953-985
-
-
Catterall, W.A.1
-
14
-
-
33745594600
-
The distribution and targeting of neuronal voltage-gated ion channels
-
Lai, H. C. & Jan, L. Y. The distribution and targeting of neuronal voltage-gated ion channels. Nature Rev. Neurosci. 7, 548-562 (2006).
-
(2006)
Nature Rev. Neurosci
, vol.7
, pp. 548-562
-
-
Lai, H.C.1
Jan, L.Y.2
-
15
-
-
0033595706
-
β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R. et al. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741 (1999).
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
-
16
-
-
0033518251
-
Purification and cloning of amyloid precursor protein β-secretase from human brain
-
Sinha, S. et al. Purification and cloning of amyloid precursor protein β-secretase from human brain. Nature 402, 537-540 (1999).
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
-
17
-
-
0036718272
-
β-Secretase protein and activity are increased in the neocortex in Alzheimer disease
-
Fukumoto, H., Cheung, B. S., Hyman, B. T. & Irizarry, M. C. β-Secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch. Neurol. 59, 1381-1389 (2002).
-
(2002)
Arch. Neurol
, vol.59
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
18
-
-
0036434569
-
α- and β-secretase: Profound changes in Alzheimer's disease
-
Tyler, S. J., Dawbarn, D., Wilcock, G. K. & Allen, S. J. α- and β-secretase: Profound changes in Alzheimer's disease. Biochem. Biophys. Res. Commun. 299, 373-376 (2002).
-
(2002)
Biochem. Biophys. Res. Commun
, vol.299
, pp. 373-376
-
-
Tyler, S.J.1
Dawbarn, D.2
Wilcock, G.K.3
Allen, S.J.4
-
19
-
-
85069079518
-
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer's disease
-
Yang, L. B. et al. Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer's disease. Nature Med. 9, 3-4 (2003).
-
(2003)
Nature Med
, vol.9
, pp. 3-4
-
-
Yang, L.B.1
-
20
-
-
30444440132
-
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
-
Laird, F. M. et al. BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J. Neurosci. 25, 11693-11709 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 11693-11709
-
-
Laird, F.M.1
-
21
-
-
0037675876
-
Characterization of α 2,6-sialyltransferase cleavage by Alzheimer's β -secretase (BACE1)
-
Kitazume, S. et al. Characterization of α 2,6-sialyltransferase cleavage by Alzheimer's β -secretase (BACE1). J. Biol. Chem. 278, 14865-14871 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14865-14871
-
-
Kitazume, S.1
-
22
-
-
0842325530
-
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
-
Lichtenthaler, S. F. et al. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J. Biol. Chem. 278, 48713-48719 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 48713-48719
-
-
Lichtenthaler, S.F.1
-
23
-
-
33750455150
-
Control of peripheral nerve myelination by the β-secretase BACE1
-
Willem, M. et al. Control of peripheral nerve myelination by the β-secretase BACE1. Science 314, 664-666 (2006).
-
(2006)
Science
, vol.314
, pp. 664-666
-
-
Willem, M.1
-
24
-
-
20744458852
-
Presenilin/γ-secretase-mediated cleavage of the voltage-gated sodium channel β2-subunit regulates cell adhesion and migration
-
Kim, D. Y., Ingano, L. A., Carey, B. W., Pettingell, W. H. & Kovacs, D. M. Presenilin/γ-secretase-mediated cleavage of the voltage-gated sodium channel β2-subunit regulates cell adhesion and migration. J. Biol. Chem. 280, 23251-23261 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23251-23261
-
-
Kim, D.Y.1
Ingano, L.A.2
Carey, B.W.3
Pettingell, W.H.4
Kovacs, D.M.5
-
25
-
-
20744454142
-
β subunits of voltage-gated sodium channels are novel substrates of β-site amyloid precursor protein-cleaving enzyme (BACE1) and γ-secretase
-
Wong, H. K. et al. β subunits of voltage-gated sodium channels are novel substrates of β-site amyloid precursor protein-cleaving enzyme (BACE1) and γ-secretase. J. Biol. Chem. 280, 23009-23017 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23009-23017
-
-
Wong, H.K.1
-
26
-
-
3142512452
-
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
-
Koo, E. H. & Kopan, R. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature Med. 10, S26-S33 (2004).
-
(2004)
Nature Med
, vol.10
-
-
Koo, E.H.1
Kopan, R.2
-
27
-
-
0033588810
-
Type I and type II Na(+) channel α-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain
-
Gong, B., Rhodes, K. J., Bekele-Arcuri, Z. & Trimmer, J. S. Type I and type II Na(+) channel α-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain. J. Comp. Neurol. 412, 342-352 (1999).
-
(1999)
J. Comp. Neurol
, vol.412
, pp. 342-352
-
-
Gong, B.1
Rhodes, K.J.2
Bekele-Arcuri, Z.3
Trimmer, J.S.4
-
28
-
-
0034686371
-
Distribution of voltage-gated sodium channel α-subunit and β-subunit mRNAs in human hippocampal formation, cortex, and cerebellum
-
Whitaker, W. R. et al. Distribution of voltage-gated sodium channel α-subunit and β-subunit mRNAs in human hippocampal formation, cortex, and cerebellum. J. Comp. Neurol. 422, 123-139 (2000).
-
(2000)
J. Comp. Neurol
, vol.422
, pp. 123-139
-
-
Whitaker, W.R.1
-
29
-
-
0035817795
-
Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus
-
Whitaker, W. R. et al. Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus. Neuroscience 106, 275-285 (2001).
-
(2001)
Neuroscience
, vol.106
, pp. 275-285
-
-
Whitaker, W.R.1
-
30
-
-
0035676059
-
Identification of epilepsy genes in human and mouse
-
Meisler, M. H., Kearney, J., Ottman, R. & Escayg. A. Identification of epilepsy genes in human and mouse. Annu. Rev. Genet. 35, 567-588 (2001).
-
(2001)
Annu. Rev. Genet
, vol.35
, pp. 567-588
-
-
Meisler, M.H.1
Kearney, J.2
Ottman, R.3
Escayg, A.4
-
31
-
-
0029879591
-
Sodium channel mRNA in the B104 neuroblastoma cell line
-
Dib-Hajj, S. D., Hinson, A. W., Black, J. A. & Waxman, S. G. Sodium channel mRNA in the B104 neuroblastoma cell line. FEBS Lett. 384, 78-82 (1996).
-
(1996)
FEBS Lett
, vol.384
, pp. 78-82
-
-
Dib-Hajj, S.D.1
Hinson, A.W.2
Black, J.A.3
Waxman, S.G.4
-
32
-
-
3042658599
-
In vivo inhibition of Abeta production by memapsin 2 (β-secretase) inhibitors
-
Chang, W. P. et al. In vivo inhibition of Abeta production by memapsin 2 (β-secretase) inhibitors. J. Neurochem. 89, 1409-1416 (2004).
-
(2004)
J. Neurochem
, vol.89
, pp. 1409-1416
-
-
Chang, W.P.1
-
33
-
-
28044432745
-
Upregulation of the voltage-gated sodium channel β2 subunit in neuropathic pain models: Characterization of expression in injured and non-injured primary sensory neurons
-
Pertin, M. et al. Upregulation of the voltage-gated sodium channel β2 subunit in neuropathic pain models: Characterization of expression in injured and non-injured primary sensory neurons. J. Neurosci. 25, 10970-10980 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 10970-10980
-
-
Pertin, M.1
-
34
-
-
13844265969
-
BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo
-
Lee, E. B. et al. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J. Cell Biol. 168, 291-302 (2005).
-
(2005)
J. Cell Biol
, vol.168
, pp. 291-302
-
-
Lee, E.B.1
-
35
-
-
0022492421
-
Biosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons
-
Schmidt, J. W. & Catterall, W. A. Biosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons. Cell 46, 437-444 (1986).
-
(1986)
Cell
, vol.46
, pp. 437-444
-
-
Schmidt, J.W.1
Catterall, W.A.2
-
36
-
-
0037901326
-
A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation
-
Thomas-Crusells, J., Vieira, A., Saarma, M. & Rivera, C. A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation. J. Neurosci. Methods 125, 159-166 (2003).
-
(2003)
J. Neurosci. Methods
, vol.125
, pp. 159-166
-
-
Thomas-Crusells, J.1
Vieira, A.2
Saarma, M.3
Rivera, C.4
-
37
-
-
0036898064
-
The human heart and rat brain IIA Na+ channels interact with different molecular regions of the β1 subunit
-
Zimmer, T. & Benndorf, K. The human heart and rat brain IIA Na+ channels interact with different molecular regions of the β1 subunit. J. Gen. Physiol. 120, 887-895 (2002).
-
(2002)
J. Gen. Physiol
, vol.120
, pp. 887-895
-
-
Zimmer, T.1
Benndorf, K.2
-
38
-
-
0034617141
-
Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes
-
Zhou, J., Yi, J., Hu, N., George, A. L., Jr. & Murray, K. T. Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes. Circ. Res. 87, 33-38 (2000).
-
(2000)
Circ. Res
, vol.87
, pp. 33-38
-
-
Zhou, J.1
Yi, J.2
Hu, N.3
George Jr., A.L.4
Murray, K.T.5
-
39
-
-
10744231282
-
BACE1 (β-secretase) transgenic and knockout mice; identification of neurochemical deficits and behavioral changes
-
Harrison, S. M. et al. BACE1 (β-secretase) transgenic and knockout mice; identification of neurochemical deficits and behavioral changes. Mol. Cell. Neurosci. 24, 646-655 (2003).
-
(2003)
Mol. Cell. Neurosci
, vol.24
, pp. 646-655
-
-
Harrison, S.M.1
-
40
-
-
25444479179
-
High β-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-β levels: Implications for the treatment of Alzheimer disease
-
Rockenstein, E. et al. High β-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-β levels: Implications for the treatment of Alzheimer disease. J. Biol. Chem. 280, 32957-32967 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 32957-32967
-
-
Rockenstein, E.1
-
41
-
-
33845236399
-
Bace1 modulates myelination in the central and peripheral nervous system
-
Hu, X. et al. Bace1 modulates myelination in the central and peripheral nervous system. Nature Neurosci. 9, 1520-1525 (2006).
-
(2006)
Nature Neurosci
, vol.9
, pp. 1520-1525
-
-
Hu, X.1
-
42
-
-
0035478007
-
Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2
-
Spampanato, J., Escayg, A., Meisler, M. H. & Goldin, A. L. Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. J. Neurosci. 21, 7481-7490 (2001).
-
(2001)
J. Neurosci
, vol.21
, pp. 7481-7490
-
-
Spampanato, J.1
Escayg, A.2
Meisler, M.H.3
Goldin, A.L.4
-
43
-
-
0034987073
-
De novo mutations in the sodium-channel gene SCNIA cause severe myoclonic epilepsy of infancy
-
Claes, L. et al. De novo mutations in the sodium-channel gene SCNIA cause severe myoclonic epilepsy of infancy. Am. J. Hum. Genet. 68, 1327-1332 (2001).
-
(2001)
Am. J. Hum. Genet
, vol.68
, pp. 1327-1332
-
-
Claes, L.1
-
44
-
-
0028139308
-
-
Mendez, M. F., Catanzaro, P., Doss, R. C., ARquello, R. & Frey, W. H., 2nd. Seizures in Alzheimer's disease: Clinicopathologic study. J. Geriatr. Psychiatry. Neurol. 7, 230-233 (1994).
-
Mendez, M. F., Catanzaro, P., Doss, R. C., ARquello, R. & Frey, W. H., 2nd. Seizures in Alzheimer's disease: Clinicopathologic study. J. Geriatr. Psychiatry. Neurol. 7, 230-233 (1994).
-
-
-
|