Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice

Journal of Biological Chemistry

Volumn 282, Issue 36, 2007, Pages 26326-26334

  McConlogue, Lisa ^a   Buttini, Manuel ^a   Anderson, John P ^a   Brigham, Elizabeth F ^a   Chen, Karen S ^a,b   Freedman, Stephen B ^a,c   Games, Dora ^a   Johnson Wood, Kelly ^a   Lee, Michael ^a   Zeller, Michelle ^a   Liu, Weiqun ^a   Motter, Ruth ^a   Sinha, Sukanto ^a,d  

^a ELAN PHARMACEUTICALS   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c SBF Consulting   (United States)

^d ActiveSite Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENE EXPRESSION; MAMMALS; MOLECULAR BIOLOGY; PATHOLOGY;

AMYLOID PRECURSOR PROTEINS (APP); SYNAPTIC DEFICITS; THERAPEUTIC INTERVENTION;

ENZYME INHIBITION;

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; SYNAPTIC MEMBRANE; TRANSGENIC MOUSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HUMANS; MICE; MICE, KNOCKOUT; NEURITES; SYNAPTIC MEMBRANES;

MUS; MUS MUSCULUS;

EID: 34548847452     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611687200     Document Type: Article

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