Heparin activates β-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme

Biochemistry

Volumn 45, Issue 21, 2006, Pages 6703-6714

  Beckman, Marie ^a   Holsinger, R M Damian ^b   Small, David H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CELLS; DISEASE CONTROL; DRUG THERAPY; ENZYME INHIBITION; PHARMACOKINETICS; PHYSIOLOGY;

CLEAVAGE; HEPARIN; NEUROBLASTOMA CELLS; PEPTIDES;

POLYSACCHARIDES;

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BETA SECRETASE; HEPARIN; RECOMBINANT ENZYME;

AFFINITY CHROMATOGRAPHY; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GEL ELECTROPHORESIS; HUMAN; IMMUNOPRECIPITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CATALYSIS; CHROMATOGRAPHY, AFFINITY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME ACTIVATION; HEPARIN; HUMANS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 33744760876     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052498t     Document Type: Article

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