The β-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain

Experimental Neurology

Volumn 184, Issue 2, 2003, Pages 1053-1057

  Sheng, Jin G ^a   Price, Donald L ^a   Koliatsos, Vassilis E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Amyloid; APP; Axonal transport; Hippocampus; Perforant pathway; secretase

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; AMYLOID BETA PROTEIN; ENZYME; NITROGEN; PRESENILIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX LESION; CONTROLLED STUDY; DEAFFERENTATION; DENTATE GYRUS; ENTORHINAL CORTEX; ENZYME ACTIVE SITE; HIPPOCAMPUS; IMMUNOREACTIVITY; MOUSE; NERVE ENDING; NERVE FIBER TRANSPORT; NONHUMAN; PERFORANT NERVE TRACT; PRIORITY JOURNAL; TRANSGENIC MOUSE; WESTERN BLOTTING;

EID: 0842320909     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2003.08.018     Document Type: Article

References (17)

1. Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., Copeland N.G., Price D.L., Sisodia S.S. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19:1997;939-945.
2. Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., Slunt H.H., Wang R., Seeger M., Levey A.I., Gandy S.E., Copeland N.G., Jenkins N.A., Price D.L., Younkin S.G., Sisodia S.S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
3. Cai H., Wang Y., McCarthy D., Wen H., Borchelt D.R., Price D.L., Wong P.C. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4:2001;233-234.
4. Citron M., Eckman C.B., Diehl T.S., Corcoran C., Ostaszewski B.L., Xia W., Levesque G., St George H.P., Younkin S.G., Selkoe D.J. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiol. Dis. 5:1998;107-116.
5. Cook D.G., Sung J.C., Golde T.E., Felsenstein K.M., Wojczyk B.S., Tanzi R.E., Trojanowski J.Q., Lee V.M., Doms R.W. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc. Natl. Acad. Sci. U. S. A. 93:1996;9223-9228.
6. Cruts M., van Duijn C.M., Backhovens H., van Den B.M., Wehnert A., Serneels S., Sherrington R., Hutton M., Hardy J., George-Hyslop P.H., Hofman A., van Broeckhoven C. Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer's disease. Hum. Mol. Genet. 7:1998;43-51.
7. Doan A., Thinakaran G., Borchelt D.R., Slunt H.H., Ratovitsky T., Podlisny M., Selkoe D.J., Seeger M., Gandy S.E., Price D.L., Sisodia S.S. Protein topology of presenilin 1. Neuron. 17:1996;1023-1030.
8. Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-Tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M.N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
9. Figueroa D.J., Morris J.A., Ma L., Kandpal G., Chen E., Li Y.M., Austin C.P. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiol. Dis. 9:2002;49-60.
10. Kamal A., Almenar-Queralt A., Leblanc J.F., Roberts E.A., Goldstein L.S. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 414:2001;643-648.
11. Moussaoui S., Czech C., Pradier L., Blanchard V., Bonici B., Gohin M., Imperato A., Revah F. Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Lett. 383:1996;219-222.
12. Octave J.N., Essalmani R., Tasiaux B., Menager J., Czech C., Mercken L. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease. J. Biol. Chem. 275:2000;1525-1528.
13. Price D.L., Sisodia S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21:1998;479-505.
14. Sheng J.G., Price D.L., Koliatsos V.E. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J. Neurosci. 22:2002;9794-9799.
15. Shizuka-Ikeda M., Matsubara E., Ikeda M., Kanai M., Tomidokoro Y., Ikeda Y., Watanabe M., Kawarabayashi T., Harigaya Y., Okamoto K., Maruyama K., Castano E.M., George-Hyslop P., Shoji M. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex. Biochem. Biophys. Res. Commun. 292:2002;571-578.
16. Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A.I., Gandy S.E., Jenkins N.A., Copeland N.G., Price D.L., Sisodia S.S. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17:1996;181-190.
17. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:1999;735-741.