Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expession

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 49, 2006, Pages 18727-18732

  Sun, Xiulian ^a,b   He, Guiqiong ^a,c   Qing, Hong ^a   Zhou, Weihui ^a   Dobie, Frederick ^a,b   Cai, Fang ^a   Staufenbiel, Matthias ^d   Huang, L Eric ^e   Song, Weihong ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c CHONGQING MEDICAL UNIVERSITY   (China)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid protein; Hypoxia inducible factor 1 ; Memory deficit; Neuritic plaque; Transcription

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACE1 GENE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO CULTURE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; SENILE PLAQUE; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANOXIA; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL LINE, TUMOR; HUMANS; MICE; MICE, TRANSGENIC; UP-REGULATION;

MUS MUSCULUS;

EID: 33845505233     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606298103     Document Type: Article

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