Control of peripheral nerve myelination by the β-secretase BACE1

Science

Volumn 314, Issue 5799, 2006, Pages 664-666

  Willem, Michael ^a   Garratt, Alistair N ^b   Novak, Bozidar ^a   Citron, Martin ^c   Kaufmann, Steve ^c   Rittger, Andrea ^d   DeStrooper, Bart ^e   Saftig, Paul ^d   Birchmeier, Carmen ^b   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c AMGEN INC   (United States)

^d UNIVERSITY OF KIEL   (Germany)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISEASE CONTROL; MUTAGENESIS; NEUROLOGY; PHYSIOLOGY;

ERBB2 KNOCKOUTS; PERIPHERAL NERVES; PROTEIN-CLEAVING ENZYME; UNPROCESSED NEUREGULIN 1;

PROTEINS;

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MUTANT PROTEIN; NEU DIFFERENTIATION FACTOR; NEUREGULIN 1 TYPE III; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; MUTATION; NERVOUS SYSTEM;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE MUTATION; GLIA CELL; HUMAN; HUMAN CELL; MOUSE; MYELINATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHWANN CELL; SENSORY NERVE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; AXONS; ENDOPEPTIDASES; GANGLIA, SPINAL; MICE; MICE, KNOCKOUT; MOTOR NEURONS; MYELIN SHEATH; NERVE TISSUE PROTEINS; NEUREGULIN-1; NEURONS, AFFERENT; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SCHWANN CELLS; SCIATIC NERVE; SPINAL CORD;

EID: 33750455150     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132341     Document Type: Article

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45. We thank Merck (X.-P. Shi) for the BACE1 inhibitor C3 and C. Blobel for pAPtag5-NRG1-β1. We also thank S. Lammich, C. Haffner, and C. Brösamle for helpful discussions and critically reading the manuscript. We especially thank C. Griffel and B. Erdrnann (Max-Delbrück-Center) for technical support and advice on electron microscopical analysis of peripheral nerves. This work was supported by the Deutsche Forschungsgemeinschaft (SFB 596 "Molecular Mechanisms of Neurodegeneration" to C.H. and SFB 665 "Developmental Disturbances in the Nervous System" to C.B. and A.N.G.) and the Leibniz Award (to C.H. and C.B.), the NeuroNE (to C.H. and B.DeS.), the APOPIS Program (Abnormal proteins in the pathogenesis of neurodegenerative disorders-an integrated project funded by the European Union under the 6th Framework Programme), Priority: Life Science for health, Contract No. LSHM-CT-2003-503330 (to C.H. and B. DeS.), the Ernst-Jung Award for Medicine (to C.H.), and the NGFN-2 (to C.H.). This study was also supported by the Alzheimer Forschungsinitiative (to A.R.), the Interuniversity Attraction Poles P5/19 of the Belgian Federal Science Policy Office (to B. DeS. and P.S.), and the Pioneer Award from the Alzheimer's Association and Geconcerteerde Onderzoeksactie (K.U. Leuven) (to B. DeS).