Alzheimer's disease is a synaptic failure

Science

Volumn 298, Issue 5594, 2002, Pages 789-791

  Selkoe, Dennis J ^a  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; MEDICAL IMAGING; NEUROLOGY; OLIGOMERS; PROTEINS;

SYNAPTIC FAILURE;

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; ENZYME INHIBITOR; GAMMA SECRETASE; PROTEIN ANTIBODY;

DISEASE; MEMORY; NERVOUS SYSTEM DISORDER;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; COGNITIVE DEFECT; DEGENERATIVE DISEASE; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; MOUSE; NERVE CELL DEGENERATION; NEUROLOGIC DISEASE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; COGNITION; HUMANS; LONG-TERM POTENTIATION; MEMBRANE PROTEINS; MEMORY; MICE; MICE, TRANSGENIC; PRESENILIN-1; SYNAPSES; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 0037174618     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074069     Document Type: Short Survey

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35. I thank M. Podlisny for editorial assistance. Supported by grants from the National Institute on Aging and a Pioneer Award from the Alzheimer Association. I am a consultant to Elan Pharmaceuticats, plc.