Post-translational processing of β-secretase (β -amyloid-converting enzyme) and its ectodomain shedding: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production

Journal of Biological Chemistry

Volumn 276, Issue 14, 2001, Pages 10879-10887

  Benjannet, Suzanne ^a   Elagoz, Aram ^a   Wickham, Louise ^a   Mamarbachi, Maya ^a   Munzer, Jon Scott ^a   Basak, Ajoy ^b   Lazure, Claude ^a   Cromlish, James A ^a   Sisodia, Sangram ^c   Checler, Frédéric ^d   Chrétien, Michel ^b   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF CHICAGO   (United States)

^d INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELLS; DISEASES;

ETIOLOGY;

ENZYMES;

AMYLOID BETA PROTEIN; BETA SECRETASE; ENZYME PRECURSOR; MUTANT PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; BACE2 PROTEIN, HUMAN; BETA SITE APP CLEAVING ENZYME 2; BETA-SITE APP CLEAVING ENZYME 2; PROTEINASE; SECRETASE;

ARTICLE; CELL ACTIVITY; CELL TRANSPORT; CONTROLLED STUDY; ECTODOMAIN SHEDDING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SYNTHESIS; TRANSLATION REGULATION; ALZHEIMER DISEASE; ANIMAL; CELL LINE; CELL MEMBRANE; CYTOSOL; METABOLISM; MOUSE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; CYTOSOL; ENDOPEPTIDASES; HUMANS; MICE; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 0035815635     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009899200     Document Type: Article

References (48)

1. Selkoe, D. J. (1997) Science 275, 630-631
2. Näslund, J., Haroutunian, V., Mohs, R., Davis, K. L., Davies, P., Greengard, P., and Buxbaum, J. D. (2000) J. Am. Med. Assoc. 233, 1571-1572
3. Checler, F. (1995) J. Neurochem. 65, 1431-1444
4. Buxbaum, J. D., Liu, K.-N., Luo, Y., Slack, J. L., Stocking, K. L., Peshon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) J. Biol. Chem. 273, 27765-2767
5. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenhol, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3922-3927
6. Koike, H., Tomioka, S., Sorimachi, H., Saido, T. C., Maruyama, K., Okuyama, A., Fujisawa-Sehara, A., Ohno, S., Suzuki, K., and Ishiura, S. (1999) Biochem. J. 343, 371-375
7. Seidah, N. G., and Chrétien, M. (1999) Brain Res. 848, 45-62
8. Anderson, E. D., Thomas, L., Hayflick, J. S., and Thomas, G. (1993) J. Biol. Chem. 268, 24887-24891
9. Lopez-Perez, E., Seidah, N. G., and Checler, F. (1999) J. Neurochem. 73, 2056-2062
10. Marcinkiewicz, M., and Seidah, N. G. (2000) J. Neurochem. 75, 2133-2143
11. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burges, T., Louis, J.-C., Collins, F., Treanor, J., Rogers, G. and Citron, M. (1999) Science 286, 735-741
12. Hussain, I., Powell, D., Howwlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., Smith, T. S., Simmons, D. L., Walsh, F. S., Dingwall, C., and Christie, G. (1999) Mol. Cell. Neurosci. 14, 419-427
13. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., John, V., Zhao, J., McConlogue, L., and John, V. (1999) Nature 402, 537-540
14. Yan, R., Bienkowski, M., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashier, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heirikson, R. L., and Gurney, M. E. (1999) Nature 402, 533-537
15. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., and Tang, J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1456-1460
16. Sauder, J. M., Arthur, J. W., and Dunbrack, R. L., Jr. (2000) J. Mol. Biol. 300, 241-248
17. Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., and Xu, H. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 742-747
18. Van Gassen, G., Annaert, W., and Van Broeckhoven, C. (2000) Neurobiol. Dis. 7, 135-151
19. Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O., and Selkoe, D. J. (1999) Biochemistry 38, 4720-4727
20. van de Loo, J. W., Creemers, J. W., Bright, N. A., Young, B. D., Roebroek, A. J., and Van de Ven, W. J. (1997) J. Biol. Chem. 272, 27116-27123
21. Benjannet, S., Savaria, D., Laslop, A., Munzer, J. S., Chrétien, M., Marcinkiewicz, M., and Seidah, N. (1997) J. Biol. Chem. 272, 26210-26218
22. Sisodia, S. S., Koo, E. H., Beyreuther, K., Unterbeck, A., and Price, D. L. (1990) Science 248, 492-495
23. Barelli, H., Lebeau, A., Vizzavona, J., Delaere, P., Chevallier, N., Drouot, C., Marambaud, P., Ancolio, K., Buxbaum, J. D., Khorkova, O., Heroux, J., Sahasrabudhe, S., Martinez, J., Warter, J.-M., Mohr, M., and Checler, F. (1997) Mol. Med. 3, 695-707
24. Zhong, M., Munzer, J. S., Basak, A., Benjannet, S., Mowla, S. J., Decroly, E., Chrétien, M., and Seidah, N. G. (1999) J. Biol. Chem. 274, 33913-33920
25. Lusson, J., Vieau, D., Hamelin, J., Day, R., Chrétien, M., and Seidah, N. G. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6691-6695
26. Seidah, N. G., Mowla, S. J., Hamelin, J., Mamarbachi, A. M., Benjannet, S., Toure, B. B., Basak, A., Munzer, J. S., Marcinkiewicz, J., Zhong, M., Barale, J. C., Lazure, C., Murphy, R. A., Chrétien, M., and Marcinkiewicz, M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1321-1326
27. Touré, B. B., Basak, A., Munzer, J. S., Benjannet, S., Rochemont, J., Lazure, C., Chrétien, M., and Seidah, N. G. (2000) J. Biol. Chem. 275, 2349-2358
28. Rompaey, L. V., Ayoubi, T., Van De Ven, W., and Marynen, P. (1997) Biochem. J. 326, 507-514
29. Decroly, E., Wouters, S., Dibello, C., Lazure, C., Ruysschaert, J. M., and Seidah, N. G. (1996) J. Biol. Chem. 271, 30442-30450
30. Munzer, J. S., Basak, A., Zhong, M., Mamarbachi, A., Hamelin, J., Savaria, D., Lazure, C., Benjannet, S., Chrétien, M., and Seidah, N. G. (1997) J. Biol. Chem. 272, 19672-19681
31. Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L., and Klausner, R. D. (1991) Cell 67, 601-616
32. Karaivanova, V. K., and Spiro, R. G. (1998) Biochem. J. 329, 511-518
33. Beisswanger, R., Corbeil, D., Vannier, C., Thiele, C., Dohrmann, U., Kellner, R., Ashman, K., Niehrs, C., and Huttner, W. B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11134-11139
34. Xiang, Y., Molloy, S. S., Thomas, L., and Thomas, G. (2000) Mol. Biol. Cell 11, 1257-1273
35. Takahashi, S., Nakagawa, T., Kasai, K., Banno, T., Duguay, S. J., Van de Ven, W. J. M., Murakami, K., and Nakayama, K. (1995) J. Biol. Chem. 270, 26565-26569
36. Schweizer, A., Kornfeld, S., and Rohrer, J. (1996) T. Cell Biol. 132, 577-584
37. Bowman, E. J., Siebers, A., and Altendorf, K. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7972-7976
38. Matlin, K. S., and Simons, K. (1983) Cell 34, 233-243
39. Skovronsky, D. M., Moore, D. B., Milla, M. E., Doms, R. W., and Lee, V. M. (1999) J. Biol. Chem. 275, 2568-2575
40. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M.-Y., and Doms, R. W. (2000) J. Biol. Chem. 275, 33729-33737
41. Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J.-C., Citron, M., and Vassar, R. (2000) J. Biol. Chem. 275, 37712-37717
42. Creemers, J. W. M., Dominiguez, D. I., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, K., Annaert, W., and De Strooper, B. (2001) J. Biol. Chem. 276, 4211-4217
43. Haniu, M., Denis, P., Young, Y., Mendiaz, E. A., Fuller, J., Hui, J. O., Bennett, B. D., Kahn, S., Ross, S., Burgess, T., Katta, V., Rogers, G., Vassar, R., and Citron, M. (2000) J. Biol. Chem. 275, 21099-21106
44. Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., and Haass, C. (2000) J. Biol. Chem. 275, 30849-30854
45. Rigot, V., Andre, F., Lehmann, M., Lissitzky, J. C., Marvaldi, J., and Luis, J. (1999) Eur. J. Biochem. 261, 659-666
46. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D. M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St. George-Hyslop, P. H., and Fraser, P. E. (1998) J. Biol. Chem. 273, 16470-16475
47. Mercure, C., Jutras, I., Day, R., Seidah, N. G., and Reudelhuber, T. L. (1996) Hypertension 28, 840-846
48. Resh, M. D. (1999) Biochim. Biophys. Acta 1451, 1-16