Lipid rafts play an important role in Aβ biogenesis by regulating the β-secretase pathway

Journal of Molecular Neuroscience

Volumn 19, Issue 1-2, 2002, Pages 31-35

  Tun, Han ^a,b   Marlow, Laura ^a   Pinnix, Inga ^a   Kinsey, Rachel ^a   Sambamurti, Kumar ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Alzheimer's disease; Amyloid; DIGs; Glycosylphosphatidylinositol; GPI anchored protein; Lipid rafts; Secretase; TIMs

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID DERIVATIVE; ASPARTIC PROTEINASE; BETA SECRETASE; BRAIN PROTEIN; CELL PROTEIN; CHAPERONE; GAMMA SECRETASE; GLYCOSYLPHOSPHATIDYLINOSITOL; LIPID; PROTEIN BACE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BRAIN CELL; BRAIN MEMBRANE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PROTEIN INTERACTION; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CELLS, CULTURED; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; GLYCOSYLPHOSPHATIDYLINOSITOLS; GUINEA PIGS; HUMANS; MEMBRANE MICRODOMAINS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0036674082     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-002-0007-5     Document Type: Article

References (15)

1. GPI-anchored proteins and detergent-resistant membrane domains
2. Functions of lipid rafts in biological membranes
3. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
4. Proteolytic processing and cell biological functions of the amyloid precursor protein
5. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
6. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
7. Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein
8. Convertases other than furin cleave beta-secretase to its mature form
9. A novel gamma-secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor
10. Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
11. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics
12. Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein
13. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
14. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
15. The role of Aβ42 in Alzheimer's disease