The APP family of proteins: Similarities and differences

Biochemical Society Transactions

Volumn 35, Issue 2, 2007, Pages 416-420

  Walsh, D M ^a,b   Minogue, A M ^a   Sala Frigerio, C ^a   Fadeeva, J V ^b   Wasco, W ^b   Selkoe, D J ^b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

amyloid cleaving enzyme (BACE); secretase; Alzheimer's disease; Amyloid precursor protein (APP); Amyloid precursor like protein (APLP); Therapy

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; PROTEIN AMYLOID PRECURSOR PROTEIN 1; PROTEIN AMYLOID PRECURSOR PROTEIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; CONFERENCE PAPER; GENE EXPRESSION; MULTIGENE FAMILY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; HUMANS; RECEPTORS, CELL SURFACE; REFERENCE VALUES;

EID: 34247123160     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0350416     Document Type: Conference Paper

References (49)

1. Walsh, D.M. and Selkoe, D.J. (2004) Neuron 44, 181-193
2. Haass, C., Schlossmacher, M., Hung, A.Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B., Lieberburg, I., Koo, E.H., Schenk, D., Teplow, D. and Selkoe, D. (1992) Nature 359, 322-325
3. Seubert, P., Oltersdorf, T., Lee, M.G., Barbour, R., Blomgist, C., Davis, D.L., Bryant, K., Fritz, L.C., Galasko, D., Thal, L.J. et al. (1993) Nature 361, 260-263
4. Shoji, M., Golde, T.E., Ghiso J., Cheung, T.T., Estus, S., Shaffer, L.M., Cai, X., McKay, D.M., Tintner, R., Frangione, B. and Selkoe, D. (1992) Science 258, 126-129
5. Kopan, R. and Ilagan, M.X. (2004) Nat. Rev. Mol. Cell Biol. 5, 499-504
6. Lichtenthaler, S.F., Dominguez, D.I., Westmeyer, G.G., Reiss, K., Haass, C., Saftig, P., De Strooper, B. and Seed, B. (2003) J. Biol. Chem. 278, 48713-48719
7. Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., De Strooper, B., Saftig, P., Birchmeier, C. and Haass, C. (2006) Science 314, 664-666
8. Coulson, E.J., Paliga, K., Beyreuther, K. and Masters, C.L. (2000) Neurochem. Int. 36, 175-184
9. Collin, R.W., van Strien, D., Leunissen, J.A. and Martens, G.J. (2004) Eur. J. Biochem. 271, 1906-1912
10. Wasco, W., Bupp, K., Magendantz, M., Gusella, J., Tanzi, R.E. and Solomon, F. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 10758-10762
11. Wasco, W., Gurubhagavatula, S., Paradis, M.D., Romano, D.M., Sisodia, S.S., Hyman, B.T., Neve, R.L. and Tanzi, R.E. (1993) Nat. Genet. 5, 95-99
12. Rosen, D.R., Martin-Morris, L., Luo, L. and White, K. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 2478-2482
13. Daigle, I. and Li, C. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 12045-12049
14. Lenkkeri, U., Kestila, M., Lamerdin, J., McCready, P., Adamson, A., Olsen, A. and Tryggvason, K. (1998) Hum. Genet. 102, 192-196
15. Slunt, H.H., Thinakaran, G., Von Koch, C., Lo, A.C. Y., Tanzi, R.E. and Sisodia, S.S. (1994) J. Biol. Chem. 269, 2637-2644
16. Heber, S., Herms, J., Gajic, V., Hainfellner, J., Aguzzi, A., Rulicke, T., von Kretzschmar, H., von Koch, C., Sisodia, S., Tremml, P. et al. (2000) J. Neurosci. 20, 7951-7963
17. Zheng, H., Jiang, M., Trumbauer, M.E., Sirinathsinghji, D.J.S., Hopkins, R., Smith, D.W., Heavesn, R.P., Dawson, G.R., Boyce, S., Conner, M.W. et al. (1995) Cell 81, 525-531
18. Dawson, G.R., Seabrook, G.R., Zheng, H., Smith, D.W., Graham, S., O'Dowd, G., Bowery, B.J., Boyce, S., Trumbauer, M.E., Chen, H.Y. et al. (1999) Neuroscience 90, 1-13
19. Muller, U., Cristina, N., Li, Z.W., Wolfer, D.P., Lipp, H.P., Rulicke, T., Brandner, S., Aguzzi, A. and Weissmann, C. (1994) Cell 79, 755-765
20. White, A.R., Reyes, R., Mercer, J.F., Camakaris, J., Zheng, H., Bush, A.I., Multhaup, G., Beyreuther, K., Masters, C.L. and Cappai, R. (1999) Brain Res. 842, 439-444
21. Herms, J., Anliker, B., Heber, S., Ring, S., Fuhrmann, M., Kretzschmar, H., Sisodia, S. and Muller, U. (2004) EMBO J. 23, 4106-4115
22. Young-Pearse, T.L., Bai, J., Zheng, J.B., LoTurco, J.J. and Selkoe, D. (2006) Alzheimer Dis. Dementia 2, 586
23. Esch, F.S., Keim, P.S., Beattie, E.C., Blacher, R.W., Culwell, A.R., Oltersdorf, T., McClure, D. and Ward, P.J. (1990) Science 248, 1122-1124
24. Parvathy, S., Karran, E.H., Turner, A.J. and Hooper, N.M. (1998) FEBS Lett. 431, 63-65
25. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C. and Fahrenholz, F. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3922-3927
26. Slack, B.E., Ma, L.K. and Seah, C.C. (2001) Biochem. J. 357, 787-794
27. Asai, M., Hattori, C., Szabo, B., Sasagawa, N., Maruyama, K., Tanuma, S. and Ishiura, S. (2003) Biochem. Biophys. Res. Commun. 301, 231-235
28. Sisodia, S.S. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6075-6079
29. Turner, III, R.T., Koelsch, G., Hong, L., Castanheira, P., Ermolieff, J., Ghosh, A.K. and Tang, J. (2001) Biochemistry 40, 10001-10006
30. Vassar, R., Bennett, B.D., Babu-Khan, S., Kahn, S., Mendiaz, E.A., Denis, P., Teplow, D.B., Ross, S., Amarante, P., Loeloff, R. et al. (1999) Science 286, 735-741
31. Cai, H.B., Wang, Y.S., McCarthy, D., Wen, H.J., Borchelt, D.R., Price, D.L. and Wong, P.C. (2001) Nat. Neurosci. 4, 233-234
32. Zhao, G., Mao, G., Tan, J., Dong, Y., Cui, M.Z., Kim, S.H. and Xu, X. (2004) J. Biol. Chem. 279, 50647-50650
33. Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K. and Ihara, Y. (2001) J. Biol. Chem. 276, 35235-35238
34. Weidemann, A., Eggert, S., Reinhard, F.B., Vogel, M., Paliga, K., Baier, G., Masters, CL., Beyreuther, K. and Evin, G. (2002) Biochemistry 41, 2825-2835
35. Kakuda, N., Funamoto, S., Yagishita, S., Takami, M., Osawa, S., Dohmae, N. and Ihara, Y. (2006) J. Biol. Chem. 281, 14776-14786
36. Thinakaran, G. and Sisodia, S.S. (1994) J. Biol. Chem. 269, 22099-22104
37. Webster, S., Lue, L.F., Brachova, L., Tenner, A.J., McGeer, P.L., Terai, K., Walker, O.G., Bradt, B., Cooper, N.R. and Rogers, J. (1997) Neurobiol. Aging 18, 415-421
38. Paliga, K., Peraus, G., Kreger, S., Durrwang, U., Hesse, L., Multhaup, G., Masters, C.L., Beyreuther, K. and Weidemann, A, (1997) Eur. J. Biochem. 250, 354-363
39. Naruse, S., Thinakaran, G., Luo, J.J., Kusiak, J.W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D.D., Price, D.L. and Borchelt, D.R. (1998) Neuron 21, 1213-1221
40. Scheinfeld, M.H., Ghersi, E., Laky, K., Fowlkes, B.J. and D'Adamio, L. (2002) J. Biol. Chem. 277, 44195-44201
41. Walsh, D.M., Fadeeva, J.V., LaVoie, M.J., Paliga, K., Eggert, S., Kimberly, W.T., Wasco, W. and Selkoe, D.J. (2003) Biochemistry 42, 6664-6673
42. Eggert, S., Paliga, K., Soba, P., Evin, G., Masters, C.L., Weidemann, A. and Beyreuther, K. (2004) J. Biol. Chem. 279, 18146-18156
43. Minogue, A., Fadeeva, J.V., Tang, J., Wasco, W., Selkoe, D.J. and Walsh, D.M. (2007) in Proceedings of the Tenth International Conference on Alzheimer's Disease and Related Disorders (Iqbal, K., Winblad, B. and Avila, J., eds), Medimond, Bologna, in the press
44. Pastorino, L., Ikin, A.F., Lamprianou, S., Vacaresse, N., Revelli, J.P., Platt, K., Paganetti, P., Mathews, P.M., Harroch, S. and Buxbaum, J.D. (2004) Mol. Cell. Neurosci. 25, 642-649
45. Endres, K., Postina, R., Schroeder, A., Mueller, U. and Fahrenholz, F. (2005) FEBS J. 272, 5808-5820
46. Li, Q. and Sudhof, T.C. (2004) J. Biol. Chem. 279, 10542-10550
47. Fadeeva, J.V., Walsh, D.M., Tang, J.T., Luo, Y., Citron, M., Wasco, W. and Selkoe, D.J. (2004) Neurobiol. Aging 25, (Suppl. 2), S158
48. Sabo, S.L., Lanier, L.M., Ikin, A.F., Khorkova, O., Sahasrabudhe, S., Greengard, P. and Buxbaum, J.D. (1999) J. Biol. Chem. 274, 7952-7957
49. Neumann, S., Schobel, S., Jager, S., Trautwein, A., Haass, C., Pietrzik, C.U. and Lichtenthaler, S.F. (2006) J. Biol. Chem. 281, 7583-7594