-
1
-
-
0242300624
-
Games played by rogue proteins in prion disorders and Alzheimer's disease
-
Aguzzi A, Haass C (2003) Games played by rogue proteins in prion disorders and Alzheimer's disease. Science 302:814-818.
-
(2003)
Science
, vol.302
, pp. 814-818
-
-
Aguzzi, A.1
Haass, C.2
-
2
-
-
33644516276
-
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11
-
Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE (2006) Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry 45:2618-2628.
-
(2006)
Biochemistry
, vol.45
, pp. 2618-2628
-
-
Andersen, O.M.1
Schmidt, V.2
Spoelgen, R.3
Gliemann, J.4
Behlke, J.5
Galatis, D.6
McKinstry, W.J.7
Parker, M.W.8
Masters, C.L.9
Hyman, B.T.10
Cappai, R.11
Willnow, T.E.12
-
3
-
-
0036441486
-
A cell biological perspective on Alzheimer's disease
-
Annaert W, de Strooper B (2002) A cell biological perspective on Alzheimer's disease. Annu Rev Cell Dev Biol 18:25-51.
-
(2002)
Annu Rev Cell Dev Biol
, vol.18
, pp. 25-51
-
-
Annaert, W.1
De Strooper, B.2
-
4
-
-
0034036097
-
A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi
-
Boman AL, Zhang C, Zhu X, Kahn RA (2000) A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. Mol Biol Cell 11:1241-1255.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 1241-1255
-
-
Boman, A.L.1
Zhang, C.2
Zhu, X.3
Kahn, R.A.4
-
5
-
-
0347762565
-
The GGA proteins: Adaptors on the move
-
Bonifacino JS (2004) The GGA proteins: adaptors on the move. Nat Rev Mol Cell Biol 5:23-32.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 23-32
-
-
Bonifacino, J.S.1
-
6
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
(Berl)
-
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239-259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
7
-
-
0034613345
-
Maturation and pro-peptide cleavage of beta-secretase
-
Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C (2000) Maturation and pro-peptide cleavage of beta-secretase. J Biol Chem 275:30849-30854.
-
(2000)
J Biol Chem
, vol.275
, pp. 30849-30854
-
-
Capell, A.1
Steiner, H.2
Willem, M.3
Kaiser, H.4
Meyer, C.5
Walter, J.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
8
-
-
0000377494
-
Processing of beta-secretase (Bace) by furin and other members of the proprotein convertase family
-
Creemers JW, Dominguez DI, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, de Strooper B (2000) Processing of beta-secretase (Bace) by furin and other members of the proprotein convertase family. J Biol Chem 8:8.
-
(2000)
J Biol Chem
, vol.8
, pp. 8
-
-
Creemers, J.W.1
Dominguez, D.I.2
Plets, E.3
Serneels, L.4
Taylor, N.A.5
Multhaup, G.6
Craessaerts, K.7
Annaert, W.8
De Strooper, B.9
-
9
-
-
0034599528
-
GGAs: A family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex
-
Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (2000) GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol 149:81-94.
-
(2000)
J Cell Biol
, vol.149
, pp. 81-94
-
-
Dell'Angelica, E.C.1
Puertollano, R.2
Mullins, C.3
Aguilar, R.C.4
Vargas, J.D.5
Hartnell, L.M.6
Bonifacino, J.S.7
-
10
-
-
0032076636
-
TIP47: A cargo selection device for mannose 6-phosphate receptor trafficking
-
Diaz E, Pfeffer SR (1998) TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell 93:433-443.
-
(1998)
Cell
, vol.93
, pp. 433-443
-
-
Diaz, E.1
Pfeffer, S.R.2
-
11
-
-
0037031658
-
Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network
-
Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S (2002) Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science 297:1700-1703.
-
(2002)
Science
, vol.297
, pp. 1700-1703
-
-
Doray, B.1
Ghosh, P.2
Griffith, J.3
Geuze, H.J.4
Kornfeld, S.5
-
12
-
-
0036319357
-
A non-amyloidogenic function of BACE-2 in the secretory pathway
-
Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J (2002) A non-amyloidogenic function of BACE-2 in the secretory pathway. J Neurochem 81:1011-1020.
-
(2002)
J Neurochem
, vol.81
, pp. 1011-1020
-
-
Fluhrer, R.1
Capell, A.2
Westmeyer, G.3
Willem, M.4
Hartung, B.5
Condron, M.M.6
Teplow, D.B.7
Haass, C.8
Walter, J.9
-
13
-
-
0037458732
-
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation
-
Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C (2003) Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. J Biol Chem 278:5531-5538.
-
(2003)
J Biol Chem
, vol.278
, pp. 5531-5538
-
-
Fluhrer, R.1
Multhaup, G.2
Schlicksupp, A.3
Okochi, M.4
Takeda, M.5
Lammich, S.6
Willem, M.7
Westmeyer, G.8
Bode, W.9
Walter, J.10
Haass, C.11
-
14
-
-
0038190920
-
Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network
-
Ghosh P, Kornfeld S (2003) Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem 278:14543-14549.
-
(2003)
J Biol Chem
, vol.278
, pp. 14543-14549
-
-
Ghosh, P.1
Kornfeld, S.2
-
15
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, Selkoe DJ (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359:322-325.
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
Selkoe, D.J.11
-
16
-
-
0028866435
-
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
-
Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1:1291-1296.
-
(1995)
Nat Med
, vol.1
, pp. 1291-1296
-
-
Haass, C.1
Lemere, C.A.2
Capell, A.3
Citron, M.4
Seubert, P.5
Schenk, D.6
Lannfelt, L.7
Selkoe, D.J.8
-
17
-
-
0034647752
-
Characterization of Alzheimer's beta-secretase protein BACE. A pepsin family member with unusual properties
-
Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M (2000) Characterization of Alzheimer's beta-secretase protein BACE. A pepsin family member with unusual properties. J Biol Chem 275:21099-21106.
-
(2000)
J Biol Chem
, vol.275
, pp. 21099-21106
-
-
Haniu, M.1
Denis, P.2
Young, Y.3
Mendiaz, E.A.4
Fuller, J.5
Hui, J.O.6
Bennett, B.D.7
Kahn, S.8
Ross, S.9
Burgess, T.10
Katta, V.11
Rogers, G.12
Vassar, R.13
Citron, M.14
-
18
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
19
-
-
0037205737
-
Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: Implications on the endocytosis mechanism of memapsin 2
-
He X, Chang WP, Koelsch G, Tang J (2002) Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. FEBS Lett 524:183-187.
-
(2002)
FEBS Lett
, vol.524
, pp. 183-187
-
-
He, X.1
Chang, W.P.2
Koelsch, G.3
Tang, J.4
-
20
-
-
0142063441
-
Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins
-
He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J (2003) Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry 42:12174-12180.
-
(2003)
Biochemistry
, vol.42
, pp. 12174-12180
-
-
He, X.1
Zhu, G.2
Koelsch, G.3
Rodgers, K.K.4
Zhang, X.C.5
Tang, J.6
-
21
-
-
15744380393
-
GGA proteins mediate the recycling pathway of memapsin 2 (BACE)
-
He X, Li F, Chang WP, Tang J (2005) GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem 280:11696-11703.
-
(2005)
J Biol Chem
, vol.280
, pp. 11696-11703
-
-
He, X.1
Li, F.2
Chang, W.P.3
Tang, J.4
-
22
-
-
0034599537
-
A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome
-
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (2000) A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. J Cell Biol 149:67-80.
-
(2000)
J Cell Biol
, vol.149
, pp. 67-80
-
-
Hirst, J.1
Lui, W.W.2
Bright, N.A.3
Totty, N.4
Seaman, M.N.5
Robinson, M.S.6
-
23
-
-
0036260892
-
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
-
Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G (2002) Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann Neurol 51:783-786.
-
(2002)
Ann Neurol
, vol.51
, pp. 783-786
-
-
Holsinger, R.M.1
McLean, C.A.2
Beyreuther, K.3
Masters, C.L.4
Evin, G.5
-
24
-
-
0034721842
-
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
-
Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW (2000) Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J Biol Chem 275:33729-33737.
-
(2000)
J Biol Chem
, vol.275
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.4
Doms, R.W.5
-
25
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14:419-427.
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
26
-
-
0037196416
-
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding
-
Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (2002) The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett 511:155-158.
-
(2002)
FEBS Lett
, vol.511
, pp. 155-158
-
-
Jacobsen, L.1
Madsen, P.2
Nielsen, M.S.3
Geraerts, W.P.4
Gliemann, J.5
Smit, A.B.6
Petersen, C.M.7
-
27
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo EH, Squazzo SL (1994) Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 269:17386-17389.
-
(1994)
J Biol Chem
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
28
-
-
13844265969
-
BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo
-
Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM (2005) BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J Cell Biol 168:291-302.
-
(2005)
J Cell Biol
, vol.168
, pp. 291-302
-
-
Lee, E.B.1
Zhang, B.2
Liu, K.3
Greenbaum, E.A.4
Doms, R.W.5
Trojanowski, J.Q.6
Lee, V.M.7
-
29
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
-
Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci USA 97:1456 -1460.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
30
-
-
0037022828
-
Glu11 site cleavage and N-terminally truncated abeta production upon BACE overexpression
-
Liu K, Doms RW, Lee VM (2002) Glu11 site cleavage and N-terminally truncated abeta production upon BACE overexpression. Biochemistry 41:3128-3136.
-
(2002)
Biochemistry
, vol.41
, pp. 3128-3136
-
-
Liu, K.1
Doms, R.W.2
Lee, V.M.3
-
31
-
-
0037085458
-
Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: Role for altered lysosomal hydrolase distribution in betaamyloidogenesis
-
Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA (2002) Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in betaamyloidogenesis. J Biol Chem 277:5299-5307.
-
(2002)
J Biol Chem
, vol.277
, pp. 5299-5307
-
-
Mathews, P.M.1
Guerra, C.B.2
Jiang, Y.3
Grbovic, O.M.4
Kao, B.H.5
Schmidt, S.D.6
Dinakar, R.7
Mercken, M.8
Hille-Rehfeld, A.9
Rohrer, J.10
Mehta, P.11
Cataldo, A.M.12
Nixon, R.A.13
-
32
-
-
0034657033
-
mu1A-adaptin-deficient mice: Lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
-
Meyer C, Zizioli D, Lausmann S, Eskelinen EL, Hamann J, Saftig P, Von Figura K, Schu P (2000) mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J 19:2193-2203.
-
(2000)
EMBO J
, vol.19
, pp. 2193-2203
-
-
Meyer, C.1
Zizioli, D.2
Lausmann, S.3
Eskelinen, E.L.4
Hamann, J.5
Saftig, P.6
Von Figura, K.7
Schu, P.8
-
33
-
-
32544435097
-
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
-
Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, Lah JJ (2006) The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 26:1596-1603.
-
(2006)
J Neurosci
, vol.26
, pp. 1596-1603
-
-
Offe, K.1
Dodson, S.E.2
Shoemaker, J.T.3
Fritz, J.J.4
Gearing, M.5
Levey, A.I.6
Lah, J.J.7
-
34
-
-
0036200884
-
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta)
-
Pastorino L, Ikin AF, Nairn AC, Pursnani A, Buxbaum JD (2002) The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol Cell Neurosci 19:175-185.
-
(2002)
Mol Cell Neurosci
, vol.19
, pp. 175-185
-
-
Pastorino, L.1
Ikin, A.F.2
Nairn, A.C.3
Pursnani, A.4
Buxbaum, J.D.5
-
35
-
-
0035369294
-
Sorting of mannose 6-phosphate receptors mediated by the GGAs
-
Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (2001) Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science 292:1712-1716.
-
(2001)
Science
, vol.292
, pp. 1712-1716
-
-
Puertollano, R.1
Aguilar, R.C.2
Gorshkova, I.3
Crouch, R.J.4
Bonifacino, J.S.5
-
36
-
-
31044445398
-
Nonsteroidal antiinflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
-
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, Van Leuven F, Heneka MT (2006) Nonsteroidal antiinflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci USA 103:443-448.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
Evert, B.O.7
Dumitrescu-Ozimek, L.8
Thal, D.R.9
Landreth, G.10
Walter, J.11
Klockgether, T.12
Van Leuven, F.13
Heneka, M.T.14
-
37
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
38
-
-
2942682767
-
Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1
-
Shiba T, Kametaka S, Kawasaki M, Shibata M, Waguri S, Uchiyama Y, Wakatsuki S (2004) Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1. Traffic 5:437-448.
-
(2004)
Traffic
, vol.5
, pp. 437-448
-
-
Shiba, T.1
Kametaka, S.2
Kawasaki, M.3
Shibata, M.4
Waguri, S.5
Uchiyama, Y.6
Wakatsuki, S.7
-
39
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, John V, et al (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
John, V.25
more..
-
40
-
-
32544432195
-
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
-
Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci 26:418-428.
-
(2006)
J Neurosci
, vol.26
, pp. 418-428
-
-
Spoelgen, R.1
Von Arnim, C.A.2
Thomas, A.V.3
Peltan, I.D.4
Koker, M.5
Deng, A.6
Irizarry, M.C.7
Andersen, O.M.8
Willnow, T.E.9
Hyman, B.T.10
-
41
-
-
23044510465
-
Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide
-
Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, Walter J (2005) Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem 280:28110-28117.
-
(2005)
J Biol Chem
, vol.280
, pp. 28110-28117
-
-
Tamboli, I.Y.1
Prager, K.2
Barth, E.3
Heneka, M.4
Sandhoff, K.5
Walter, J.6
-
42
-
-
0037172826
-
Phases of A beta-deposition in the human brain and its relevance for the development of AD
-
Thal DR, Rub U, Orantes M, Braak H (2002) Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791-1800.
-
(2002)
Neurology
, vol.58
, pp. 1791-1800
-
-
Thal, D.R.1
Rub, U.2
Orantes, M.3
Braak, H.4
-
43
-
-
0344737582
-
Vascular pathology in Alzheimer disease: Correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
-
Thal DR, Ghebremedhin E, Orantes M, Wiestler OD (2003) Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline. J Neuropathol Exp Neurol 62:1287-1301.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 1287-1301
-
-
Thal, D.R.1
Ghebremedhin, E.2
Orantes, M.3
Wiestler, O.D.4
-
44
-
-
0030681215
-
Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
-
The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
-
The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 18:S1-S2.
-
(1997)
Neurobiol Aging
, vol.18
-
-
-
45
-
-
0029942495
-
Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the Golgi apparatus
-
Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS (1996) Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the Golgi apparatus. J Biol Chem 271:9390-9397.
-
(1996)
J Biol Chem
, vol.271
, pp. 9390-9397
-
-
Thinakaran, G.1
Teplow, D.B.2
Siman, R.3
Greenberg, B.4
Sisodia, S.S.5
-
46
-
-
0033623415
-
Abeta-generating enzymes: Recent advances in beta- And gamma-secretase research
-
Vassar R, Citron M (2000) Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron 27:419-422.
-
(2000)
Neuron
, vol.27
, pp. 419-422
-
-
Vassar, R.1
Citron, M.2
-
47
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
more..
-
48
-
-
9444282652
-
Demonstration of BACE ({beta}-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy
-
von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT (2004) Demonstration of BACE ({beta}-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. J Cell Sci 117:5437-5445.
-
(2004)
J Cell Sci
, vol.117
, pp. 5437-5445
-
-
Von Arnim, C.A.1
Tangredi, M.M.2
Peltan, I.D.3
Lee, B.M.4
Irizarry, M.C.5
Kinoshita, A.6
Hyman, B.T.7
-
49
-
-
20444377260
-
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
-
Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J (2005) GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol Cell Neurosci 29:453-461.
-
(2005)
Mol Cell Neurosci
, vol.29
, pp. 453-461
-
-
Wahle, T.1
Prager, K.2
Raffler, N.3
Haass, C.4
Famulok, M.5
Walter, J.6
-
50
-
-
0035477333
-
The cell biology of Alzheimer's disease: Uncovering the secrets of secretases
-
Walter J, Kaether C, Steiner H, Haass C (2001a) The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Curr Opin Neurobiol 11:585-690.
-
(2001)
Curr Opin Neurobiol
, vol.11
, pp. 585-690
-
-
Walter, J.1
Kaether, C.2
Steiner, H.3
Haass, C.4
-
51
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of beta-secretase
-
Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C (2001b) Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem 276:14634-14641.
-
(2001)
J Biol Chem
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
Willem, M.4
Kaether, C.5
Capell, A.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
52
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity. Nature 402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
53
-
-
0037236622
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
-
Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y (2003) Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med 9:3-4.
-
(2003)
Nat Med
, vol.9
, pp. 3-4
-
-
Yang, L.B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.L.6
Beach, T.7
Sue, L.8
Wong, P.9
Price, D.10
Li, R.11
Shen, Y.12
-
54
-
-
0035369692
-
Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor
-
Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S (2001) Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. Science 292:1716-1718.
-
(2001)
Science
, vol.292
, pp. 1716-1718
-
-
Zhu, Y.1
Doray, B.2
Poussu, A.3
Lehto, V.P.4
Kornfeld, S.5
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