β-secretase (BACE) as a drug target for Alzheimer's disease

Advanced Drug Delivery Reviews

Volumn 54, Issue 12, 2002, Pages 1589-1602

  Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; APP Processing; A Peptide; BACE; Amyloid; Secretase

Indexed keywords

BIOSYNTHESIS; BRAIN; DRUG THERAPY; ENZYMES; GENES; PHYSIOLOGY; TOXICITY; X RAYS;

MUTATIONS;

PATHOLOGY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; BETA SECRETASE INHIBITOR; ENZYME INHIBITOR; GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN 1; PRESENILIN 2; PROTEINASE; UNCLASSIFIED DRUG; BACE1 PROTEIN, HUMAN; BACE2 PROTEIN, HUMAN; BETA SITE APP CLEAVING ENZYME 2; BETA-SITE APP CLEAVING ENZYME 2; PROTEINASE INHIBITOR; SECRETASE;

ALZHEIMER DISEASE; BRAIN; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; DISEASE COURSE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; FAMILIAL DISEASE; GENE MUTATION; HUMAN; KNOCKOUT MOUSE; MOLECULAR CLONING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REVIEW; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; DRUG DELIVERY SYSTEMS; ENDOPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS;

EID: 0037038816     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00157-6     Document Type: Article

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