The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo

EMBO Journal

Volumn 25, Issue 2, 2006, Pages 432-443

  Crameri, Arames ^a   Biondi, Elisa ^b   Kuehnle, Katrin ^a   Lütjohann, Dieter ^c   Thelen, Karin M ^c   Perga, Simona ^b   Dotti, Carlos G ^b,d   Nitsch, Roger M ^a   Ledesma, Maria Dolores ^b,d   Mohajeri, M Hasan ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF BONN   (Germany)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

A ; Alzheimer; Cholesterol; Neurodegeneration; Therapy

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CHOLESTEROL; PLASMINOGEN; PROTEIN; SELADIN 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DHCR24 GENE; DOWN REGULATION; FUNCTIONAL PROTEOMICS; GENE; GENETIC CODE; HUMAN; HUMAN CELL; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROCESSING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; BRAIN; CELL LINE; CELL MEMBRANE; CHOLESTEROL; DNA PRIMERS; ENDOPEPTIDASES; HUMANS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PEPTIDE FRAGMENTS; PLASMIN; PLASMINOGEN; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC;

ANIMALIA;

EID: 31444454174     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600938     Document Type: Article

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