Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 2, 2006, Pages 443-448

  Sastre, Magdalena ^a   Dewachter, Ilse ^b   Rossner, Steffen ^c   Bogdanovic, Nenad ^d   Rosen, Evan ^e   Borghgraef, Peter ^b   Evert, Bernd O ^a   Dumitrescu Ozimek, Lucia ^a   Thal, Dietmar R ^a   Landreth, Gary ^f   Walter, Jochen ^a   Klockgether, Thomas ^a   Van Leuven, Fred ^b   Heneka, Michael T ^a,g  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f CASE WESTERN RESERVE UNIVERSITY   (United States)

^g UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Alzheimer's disease; Amyloid; Inflammation; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; BRAIN EXTRACT; CYTOKINE; IBUPROFEN; INDOMETACIN; MESSENGER RNA; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PROTEIN BACE1; SMALL INTERFERING RNA; SULINDAC SULFIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN PROTECTION; CELL STRAIN HEK293; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MALE; MOUSE; MUTAGENESIS; NONHUMAN; PPAR GAMMA RESPONSE ELEMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ENDOPEPTIDASES; BRAIN; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; ENDOPEPTIDASES; FEMALE; HUMANS; IBUPROFEN; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; PPAR GAMMA; PROMOTER REGIONS (GENETICS); RATS; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS MUSCULUS;

EID: 31044445398     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0503839103     Document Type: Article

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