Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

Neuron

Volumn 57, Issue 5, 2008, Pages 680-690

  Wen, Yi ^a   Yu, W Haung ^a   Maloney, Bryan ^b   Bailey, Jason ^b   Ma, Junrong ^b   Marié, Isabelle ^c   Maurin, Thomas ^a   Wang, Lili ^a   Figueroa, Helen ^a   Herman, Mathieu ^a   Krishnamurthy, Pavan ^a   Liu, Li ^a   Planel, Emmanuel ^a   Lau, Lit Fui ^d   Lahiri, Debomoy K ^b   Duff, Karen ^a  

^a Department of Medicine   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PFIZER INC   (United States)

Author keywords

CELLBIO; HUMDISEASE; MOLNEURO

Indexed keywords

BETA SECRETASE; CYCLIN DEPENDENT KINASE 5; PROTEIN P25; STAT3 PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BACE1 GENE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE OVEREXPRESSION; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 5; HUMANS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; PC12 CELLS; RATS; TRANSCRIPTION, GENETIC;

EID: 40249114794     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2008.02.024     Document Type: Article

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