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Volumn 22, Issue 22, 2002, Pages 9785-9793

Evidence that synaptically released β-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice

Author keywords

Alzheimer's disease; Amyloid deposition; Amyloid precursor protein; Hippocampus; Perforant pathway; Synapse

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

EID: 0037111837     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-22-09785.2002     Document Type: Article
Times cited : (275)

References (52)
  • 2
    • 0029128737 scopus 로고
    • Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve
    • Amaratunga A, Fine RE (1995) Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve. J Biol Chem 270:17268-17272.
    • (1995) J Biol Chem , vol.270 , pp. 17268-17272
    • Amaratunga, A.1    Fine, R.E.2
  • 7
    • 0029686696 scopus 로고    scopus 로고
    • Evolution of the neuropathology of Alzheimer's disease
    • Braak H, Braak E (1996) Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165:3-12.
    • (1996) Acta Neurol Scand Suppl , vol.165 , pp. 3-12
    • Braak, H.1    Braak, E.2
  • 8
    • 0028210962 scopus 로고
    • Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat
    • Braak H, Braak E, Strothjohann M (1994) Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neurosci Lett 171:1-4.
    • (1994) Neurosci Lett , vol.171 , pp. 1-4
    • Braak, H.1    Braak, E.2    Strothjohann, M.3
  • 11
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98:8850-8855.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 12
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295:2264-2267.
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 13
    • 0035898257 scopus 로고    scopus 로고
    • The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease
    • Dickson TC, Vickers JC (2001) The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience 105:99-107.
    • (2001) Neuroscience , vol.105 , pp. 99-107
    • Dickson, T.C.1    Vickers, J.C.2
  • 15
    • 0027215550 scopus 로고
    • Intraneuronal compartments of the amyloid precursor protein
    • Ferreira A, Caceres A, Kosik KS (1993) Intraneuronal compartments of the amyloid precursor protein. J Neurosci 13:3112-3123.
    • (1993) J Neurosci , vol.13 , pp. 3112-3123
    • Ferreira, A.1    Caceres, A.2    Kosik, K.S.3
  • 17
    • 0031148554 scopus 로고    scopus 로고
    • Sprouting in the hippocampus is layer-specific
    • Frotscher M, Heimrich B, Deller T (1997) Sprouting in the hippocampus is layer-specific. Trends Neurosci 20:218-223.
    • (1997) Trends Neurosci , vol.20 , pp. 218-223
    • Frotscher, M.1    Heimrich, B.2    Deller, T.3
  • 18
    • 0033205121 scopus 로고    scopus 로고
    • The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments
    • Garbuglia M, Verzini M, Sorci G, Bianchi R, Giambanco I, Agneletti AL, Donato R (1999) The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. Braz J Med Biol Res 32:1177-1185.
    • (1999) Braz J Med Biol Res , vol.32 , pp. 1177-1185
    • Garbuglia, M.1    Verzini, M.2    Sorci, G.3    Bianchi, R.4    Giambanco, I.5    Agneletti, A.L.6    Donato, R.7
  • 20
    • 0015291021 scopus 로고
    • Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation
    • Hjorth-Simonsen A, Jeune B (1972) Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation. J Comp Neurol 144:215-232.
    • (1972) J Comp Neurol , vol.144 , pp. 215-232
    • Hjorth-Simonsen, A.1    Jeune, B.2
  • 23
    • 0030612033 scopus 로고    scopus 로고
    • APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1
    • Irizarry MC, McNamara M, Fedorchak K, Hsiao K, Hyman BT (1997a) APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol 56:965-973.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 965-973
    • Irizarry, M.C.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 24
    • 0030611097 scopus 로고    scopus 로고
    • Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, Hyman BT (1997b) Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 17:7053-7059.
    • (1997) J Neurosci , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 25
    • 0034075589 scopus 로고    scopus 로고
    • Axonal membrane proteins are transported in distinct carriers: A two-color video microscopy study in cultured hippocampal neurons
    • Kaether C, Skehel P, Dotti CG (2000) Axonal membrane proteins are transported in distinct carriers: A two-color video microscopy study in cultured hippocampal neurons. Mol Biol Cell 11:1213-1224.
    • (2000) Mol Biol Cell , vol.11 , pp. 1213-1224
    • Kaether, C.1    Skehel, P.2    Dotti, C.G.3
  • 26
    • 0033636136 scopus 로고    scopus 로고
    • Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
    • Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS (2000) Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 28:449-459.
    • (2000) Neuron , vol.28 , pp. 449-459
    • Kamal, A.1    Stokin, G.B.2    Yang, Z.3    Xia, C.H.4    Goldstein, L.S.5
  • 27
    • 0035818998 scopus 로고    scopus 로고
    • Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
    • Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414:643-648.
    • (2001) Nature , vol.414 , pp. 643-648
    • Kamal, A.1    Almenar-Queralt, A.2    LeBlanc, J.F.3    Roberts, E.A.4    Goldstein, L.S.5
  • 32
    • 0015951780 scopus 로고
    • Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities
    • Nadler JV, Matthews DA, Cotman CW, Lynch GS (1974) Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities. Dev Biol 36:142-154.
    • (1974) Dev Biol , vol.36 , pp. 142-154
    • Nadler, J.V.1    Matthews, D.A.2    Cotman, C.W.3    Lynch, G.S.4
  • 33
    • 0017336135 scopus 로고
    • Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions
    • Nadler JV, Cotman CW, Paoletti C, Lynch GS (1.977) Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions. J Comp Neurol 171:589-604.
    • (1977) J Comp Neurol , vol.171 , pp. 589-604
    • Nadler, J.V.1    Cotman, C.W.2    Paoletti, C.3    Lynch, G.S.4
  • 34
    • 0030611584 scopus 로고    scopus 로고
    • Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein
    • Narita M, Holtzman DM, Schwartz AL, Bu G (1997) Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J Neurochem 69:1904-1911.
    • (1997) J Neurochem , vol.69 , pp. 1904-1911
    • Narita, M.1    Holtzman, D.M.2    Schwartz, A.L.3    Bu, G.4
  • 35
    • 0035116513 scopus 로고    scopus 로고
    • Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation
    • Pigino G, Pelsman A, Mori H, Busciglio J (2001) Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21:834-842.
    • (2001) J Neurosci , vol.21 , pp. 834-842
    • Pigino, G.1    Pelsman, A.2    Mori, H.3    Busciglio, J.4
  • 36
    • 0031921466 scopus 로고    scopus 로고
    • Mutant genes in familial Alzheimer's disease and transgenic models
    • Price DL, Sisodia SS (1998) Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 21:479-505.
    • (1998) Annu Rev Neurosci , vol.21 , pp. 479-505
    • Price, D.L.1    Sisodia, S.S.2
  • 37
    • 0026042933 scopus 로고
    • Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques
    • Probst A, Langui D, Ipsen S, Robakis N, Ulrich J (1991) Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathol 83:21-29.
    • (1991) Acta Neuropathol , vol.83 , pp. 21-29
    • Probst, A.1    Langui, D.2    Ipsen, S.3    Robakis, N.4    Ulrich, J.5
  • 41
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81:741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 43
    • 0027212769 scopus 로고
    • Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
    • Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL (1993) Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J Neurosci 13:3136-3142.
    • (1993) J Neurosci , vol.13 , pp. 3136-3142
    • Sisodia, S.S.1    Koo, E.H.2    Hoffman, P.N.3    Perry, G.4    Price, D.L.5
  • 44
    • 0017163392 scopus 로고
    • Reinnervation of dentate gyrus by homologous afferents following entorhinal cortical lesions in adult rats
    • Steward O (1976) Reinnervation of dentate gyrus by homologous afferents following entorhinal cortical lesions in adult rats. Science 194:426-428.
    • (1976) Science , vol.194 , pp. 426-428
    • Steward, O.1
  • 45
    • 0017200805 scopus 로고
    • Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat
    • Steward O, Scoville SA (1976) Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat. J Comp Neurol 169:347-370.
    • (1976) J Comp Neurol , vol.169 , pp. 347-370
    • Steward, O.1    Scoville, S.A.2
  • 46
    • 0017809945 scopus 로고
    • Identification of the cells of origin of a central pathway which sprouts following lesions in mature rats
    • Steward O, Vinsant SL (1978) Identification of the cells of origin of a central pathway which sprouts following lesions in mature rats. Brain Res 147:223-243.
    • (1978) Brain Res , vol.147 , pp. 223-243
    • Steward, O.1    Vinsant, S.L.2
  • 47
    • 0027452485 scopus 로고
    • Projection of the entorhinal layer II neurons in the rat as revealed by intracellular pressure-injection of neurobiotin
    • Tamamaki N, Nojyo Y (1993) Projection of the entorhinal layer II neurons in the rat as revealed by intracellular pressure-injection of neurobiotin. Hippocampus 3:471-480.
    • (1993) Hippocampus , vol.3 , pp. 471-480
    • Tamamaki, N.1    Nojyo, Y.2
  • 49
    • 0032144472 scopus 로고    scopus 로고
    • Morphological features of the entorhinal-hippocampal connection
    • Turner DA, Buhl EH, Hailer NP, Nitsch R (1998) Morphological features of the entorhinal-hippocampal connection. Prog Neurobiol 55:537-562.
    • (1998) Prog Neurobiol , vol.55 , pp. 537-562
    • Turner, D.A.1    Buhl, E.H.2    Hailer, N.P.3    Nitsch, R.4
  • 51
    • 0030249343 scopus 로고    scopus 로고
    • Dystrophic neurite formation associated with age-related beta amyloid deposition in the neocortex: Clues to the genesis of neurofibrillary pathology
    • Vickers JC, Chin D, Edwards AM, Sampson V, Harper C, Morrison J (1996) Dystrophic neurite formation associated with age-related beta amyloid deposition in the neocortex: Clues to the genesis of neurofibrillary pathology. Exp Neurol 141:1-11.
    • (1996) Exp Neurol , vol.141 , pp. 1-11
    • Vickers, J.C.1    Chin, D.2    Edwards, A.M.3    Sampson, V.4    Harper, C.5    Morrison, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.