Xenobiotic perturbation of ER stress and the unfolded protein response

Toxicologic Pathology

Volumn 41, Issue 2, 2013, Pages 235-262

  Lafleur, Marc A ^a   Stevens, James L ^b   Lawrence, Jeffrey W ^a  

^a AMGEN INC   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

ATF6; ER stress; IRE1; PERK; unfolded protein response; xenobiotic

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 PHENYLBUTYRIC ACID; ACETYLCYSTEINE; ATAZANAVIR; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; BREFELDIN A; CELECOXIB; DANTROLENE; DITHIOTHREITOL; EEYERESTATIN I; FLAVONOID; FLUSPIRILENE; GSK 2606414; GUANABENZ; INDOMETACIN; LITHIUM; LOPINAVIR; NELFINAVIR; RESVERATROL; RITONAVIR; SALUBRINAL; SORAFENIB; STF 083010; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VERSIPELOSTATIN; XENOBIOTIC AGENT;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; AUTOPHAGY; BINDING SITE; BIPOLAR DISORDER; CALCIUM CELL LEVEL; CELL CYCLE ARREST; CELL DEATH; CELL DIFFERENTIATION; CELL PROTECTION; CELL SURVIVAL; CELL TYPE; CEREBROVASCULAR ACCIDENT; CHOLESTASIS; CONFORMATIONAL TRANSITION; CYTOSOL; CYTOTOXICITY; DIFFERENTIATION; DNA DAMAGE; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GLOMERULONEPHRITIS; HEART DISEASE; HEPATITIS B; HEPATITIS C; HOMEOSTASIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIVER DYSFUNCTION; MITOCHONDRIAL MEMBRANE; NEGATIVE FEEDBACK; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OLIGOMERIZATION; OPEN READING FRAME; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SUMOYLATION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; ENDOPLASMIC RETICULUM STRESS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN FOLDING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; XENOBIOTICS;

EID: 84875734137     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312470764     Document Type: Article

References (307)

1. Acharya P., Engel J. C., Correia M. A.. Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff. Mol Pharmacol. 2009 ; 76: 503-15
2. Acosta-Alvear D., Zhou Y., Blais A., Tsikitis M., Lents N. H., Arias C., Lennon C. J., Kluger Y., Dynlacht B. D.. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Molecular Cell. 2007 ; 27: 53-66
3. Aires C. C., Ijlst L., Stet F., Prip-Buus C., de Almeida I. T., Duran M., Wanders R. J., Silva M. F.. Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. Biochem Pharmacol. 2010 ; 79: 792-99
4. Ameri K., Harris A. L.. Activating transcription factor 4. Int J Biochem Cell Biol. 2008 ; 40: 14-21
5. Anckar J., Sistonen L.. Regulation of HSF1 function in the heat stress response: Implications in aging and disease. Ann Rev Biochem. 2011 ; 80: 1089-115
6. Andre P., Groettrup M., Klenerman P., de Giuli R., Booth B. L., Cerundolo V., Bonneville M., Jotereau F., Zinkernagel R. M., Lotteau V.. An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses. Proc Natl Acad Sci USA. 1998 ; 95: 13120-24
7. Aragon I. V., Barrington R. A., Jackowski S., Mori K., Brewer J. W.. The specialized unfolded protein response of B lymphocytes: ATF6alpha-independent development of antibody-secreting B cells. Mol Immunol. 2012 ; 51: 347-55
8. Asmellash S., Stevens J. L., Ichimura T.. Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo. Toxicol Sci. 2005 ; 88: 576-84
9. Atkin J. D., Farg M. A., Walker A. K., McLean C., Tomas D., Horne M. K.. Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis. Neurobiol Dis. 2008 ; 30: 400-407
10. Austin R. C.. The unfolded protein response in health and disease. Antioxid Redox Signal. 2009 ; 11: 2279-87
11. Axten J. M., Medina J. R., Feng Y., Shu A., Romeril S. P., Grant S. W., Li W. H., Heerding D. A., Minthorn E., Mencken T., Atkins C., Liu Q., Rabindran S., Kumar R., Hong X., Goetz A., Stanley T., Taylor J. D., Sigethy S. D., Tomberlin G. H., Hassell A. M., Kahler K. M., Shewchuk L. M., Gampe R. T.. Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H- indol-5-yl)-7H-p yrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 ; 55: 7193-207
12. Bando Y., Tsukamoto Y., Katayama T., Ozawa K., Kitao Y., Hori O., Stern D. M., Yamauchi A., Ogawa S.. ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. FASEB J. 2004 ; 18: 1401-1403
13. Ben Mosbah I., Alfany-Fernandez I., Martel C., Zaouali M. A., Bintanel-Morcillo M., Rimola A., Rodes J., Brenner C., Rosello-Catafau J., Peralta C.. Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. Cell Death Dis. 2010 ; 1: e52
14. Bence N. F., Sampat R. M., Kopito R. R.. Impairment of the ubiquitin-proteasome system by protein aggregation. Science. 2001 ; 292: 1552-55
15. Bernales S., McDonald K. L., Walter P.. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol. 2006 ; 4: e423
16. Bertolotti A., Wang X., Novoa I., Jungreis R., Schlessinger K., Cho J. H., West A. B., Ron D.. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clinical Invest. 2001 ; 107: 585-93
17. Bertolotti A., Zhang Y., Hendershot L. M., Harding H. P., Ron D.. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol. 2000 ; 2: 326-32
18. Boelens J., Lust S., Offner F., Bracke M. E., Vanhoecke B. W.. Review. The endoplasmic reticulum: A target for new anticancer drugs. In Vivo. 2007 ; 21: 215-26
19. Bouvier N., Flinois J. P., Gilleron J., Sauvage F. L., Legendre C., Beaune P., Thervet E., Anglicheau D., Pallet N.. Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: A role for endothelial phenotypic changes and death. Am J Physiol. Renal Physiol. 2009 ; 296: F160-69
20. Bown C. D., Wang J. F., Chen B., Young L. T.. Regulation of ER stress proteins by valproate: Therapeutic implications. Bipolar Disord. 2002 ; 4: 145-51
21. Bown C. D., Wang J. F., Young L. T.. Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells. Neuropharmacology. 2000 ; 39: 2162-69
22. Boyce M., Bryant K. F., Jousse C., Long K., Harding H. P., Scheuner D., Kaufman R. J., Ma D., Coen D. M., Ron D., Yuan J.. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 ; 307: 935-39
23. Brewer J. W., Hendershot L. M., Sherr C. J., Diehl J. A.. Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci USA. 1999 ; 96: 8505-10
24. Brewster J. L., Linseman D. A., Bouchard R. J., Loucks F. A., Precht T. A., Esch E. A., Heidenreich K. A.. Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol Cell Neurosci. 2006 ; 32: 242-53
25. Buchberger A., Bukau B., Sommer T.. Protein quality control in the cytosol and the endoplasmic reticulum: Brothers in arms. Mol Cell. 2010 ; 40: 238-52
26. Calfon M., Zeng H., Urano F., Till J. H., Hubbard S. R., Harding H. P., Clark S. G., Ron D.. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 2002 ; 415: 92-96
27. Carew J. S., Nawrocki S. T., Krupnik Y. V., Dunner K., McConkey D. J., Keating M. J., Huang P.. Targeting endoplasmic reticulum protein transport: A novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL. Blood. 2006 ; 107: 222-31
28. Cawley K., Deegan S., Samali A., Gupta S.. Assays for detecting the unfolded protein response. Methods Enzymol. 2011 ; 490: 31-51
29. Chae H. J., Kim H. R., Xu C., Bailly-Maitre B., Krajewska M., Krajewski S., Banares S., Cui J., Digicaylioglu M., Ke N., Kitada S., Monosov E., Thomas M., Kress C. L., Babendure J. R., Tsien R. Y., Lipton S. A., Reed J. C.. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell. 2004 ; 15: 355-66
30. Chakrabarti A., Chen A. W., Varner J. D.. A review of the mammalian unfolded protein response. Biotechnol Bioeng. 2011 ; 108: 2777-93
31. Chen B., Wang J. F., Young L. T.. Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus. Biol Psychiatry. 2000 ; 48: 658-64
32. Chen H., Qi L.. SUMO modification regulates the transcriptional activity of XBP1. Biochem J. 2010 ; 429: 95-102
33. Chen J. J., London I. M.. Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase. Trends Biochem Sci. 1995 ; 20: 105-108
34. Cheng E. H., Wei M. C., Weiler S., Flavell R. A., Mak T. W., Lindsten T., Korsmeyer S. J.. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001 ; 8: 705-11
35. Choi A. Y., Choi J. H., Lee J. Y., Yoon K. S., Choe W., Ha J., Yeo E. J., Kang I.. Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis. Neurochem Int. 2010 ; 57: 143-52
36. Choi J. H., Choi A. Y., Yoon H., Choe W., Yoon K. S., Ha J., Yeo E. J., Kang I.. Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction. Exp Mol Med. 2010 ; 42: 811-22
37. Cichon S., Buervenich S., Kirov G., Akula N., Dimitrova A., Green E., Schumacher J., Klopp N., Becker T., Ohlraun S., Schulze T. G., Tullius M., Gross M. M., Jones L., Krastev S., Nikolov I., Hamshere M., Jones I., Czerski P. M., Leszczynska-Rodziewicz A., Kapelski P., Bogaert A. V., Illig T., Hauser J., Maier W., Berrettini W., Byerley W., Coryell W., Gershon E. S., Kelsoe J. R., McInnis M. G., Murphy D. L., Nurnberger J. I., Reich T., Scheftner W., O'Donovan M. C., Propping P., Owen M. J., Rietschel M., Nothen M. M., McMahon F. J., Craddock N.. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nat Genet. 2004 ; 36: 783-84
38. Cnop M., Ladriere L., Hekerman P., Ortis F., Cardozo A. K., Dogusan Z., Flamez D., Boyce M., Yuan J., Eizirik D. L.. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem. 2007 ; 282: 3989-97
39. Corrigall V. M., Bodman-Smith M. D., Fife M. S., Canas B., Myers L. K., Wooley P., Soh C., Staines N. A., Pappin D. J., Berlo S. E., van Eden W., van Der Zee R., Lanchbury J. S., Panayi G. S.. The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol. 2001 ; 166: 1492-98
40. Cullinan S. B., Zhang D., Hannink M., Arvisais E., Kaufman R. J., Diehl J. A.. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003 ; 23: 7198-209
41. Cybulsky A. V.. Endoplasmic reticulum stress in proteinuric kidney disease. Kidney Inter. 2010 ; 77: 187-93
42. Dalal S., Foster C. R., Das B. C., Singh M., Singh K.. Beta-adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: Role in apoptosis. Mol Cellular Biochem. 2012 ; 364: 59-70
43. DenBoer L. M., Hardy-Smith P. W., Hogan M. R., Cockram G. P., Audas T. E., Lu R.. Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem Biophys Res Commun. 2005 ; 331: 113-19
44. Deng J., Lu P. D., Zhang Y., Scheuner D., Kaufman R. J., Sonenberg N., Harding H. P., Ron D.. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol. 2004 ; 24: 10161-68
45. Ding W. X., Ni H. M., Gao W., Yoshimori T., Stolz D. B., Ron D., Yin X. M.. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol. 2007 ; 171: 513-24
46. DuRose J. B., Tam A. B., Niwa M.. Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress. Mol Biol Cell. 2006 ; 17: 3095-107
47. Egger L., Schneider J., Rheme C., Tapernoux M., Hacki J., Borner C.. Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ. 2003 ; 10: 1188-203
48. Ellgaard L., Molinari M., Helenius A.. Setting the standards: Quality control in the secretory pathway. Science. 1999 ; 286: 1882-888
49. Erbay E., Babaev V. R., Mayers J. R., Makowski L., Charles K. N., Snitow M. E., Fazio S., Wiest M. M., Watkins S. M., Linton M. F., Hotamisligil G. S.. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med. 2009 ; 15: 1383-91
50. Fernandez J., Bode B., Koromilas A., Diehl J. A., Krukovets I., Snider M. D., Hatzoglou M.. Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. J Biol Chem. 2002 ; 277: 11780-787
51. Fernandez P. M., Tabbara S. O., Jacobs L. K., Manning F. C., Tsangaris T. N., Schwartz A. M., Kennedy K. A., Patierno S. R.. Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Canc Res Treat. 2000 ; 59: 15-26
52. Fonseca S. G., Ishigaki S., Oslowski C. M., Lu S., Lipson K. L., Ghosh R., Hayashi E., Ishihara H., Oka Y., Permutt M. A., Urano F.. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest. 2010 ; 120: 744-55
53. Frankland-Searby S., Bhaumik S. R.. The 26S proteasome complex: An attractive target for cancer therapy. Biochim Biophys Acta. 2012 ; 1825: 64-76
54. Fujimoto M., Nakai A.. The heat shock factor family and adaptation to proteotoxic stress. FEBS J. 2010 ; 277: 4112-25
55. Fujimoto T., Onda M., Nagai H., Nagahata T., Ogawa K., Emi M.. Upregulation and overexpression of human X-box binding protein 1 (hXBP-1) gene in primary breast cancers. Breast Canc. 2003 ; 10: 301-306
56. Garcia M. A., Meurs E. F., Esteban M.. The dsRNA protein kinase PKR: Virus and cell control. Biochimie. 2007 ; 89: 799-811
57. Gargalovic P. S., Gharavi N. M., Clark M. J., Pagnon J., Yang W. P., He A., Truong A., Baruch-Oren T., Berliner J. A., Kirchgessner T. G., Lusis A. J.. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol. 2006 ; 26: 2490-96
58. Gass J. N., Jiang H. Y., Wek R. C., Brewer J. W.. The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Mol Immunol. 2008 ; 45: 1035-43
59. Ghosh H. S., Reizis B., Robbins P. D.. SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Scientific Reports. 2011 ; 1: 150
60. GiamM.HuangD. C.BouilletP. (2008). BH3-only proteins and their roles in programmed cell death. Oncogene27Suppl 1, S128-36.
61. Gills J. J., Lopiccolo J., Tsurutani J., Shoemaker R. H., Best C. J., Abu-Asab M. S., Borojerdi J., Warfel N. A., Gardner E. R., Danish M., Hollander M. C., Kawabata S., Tsokos M., Figg W. D., Steeg P. S., Dennis P. A.. Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Canc Res. 2007 ; 13: 5183-94
62. Gorlach A., Klappa P., Kietzmann T.. The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal. 2006 ; 8: 1391-418
63. Gu F., Nguyen D. T., Stuible M., Dube N., Tremblay M. L., Chevet E.. Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem. 2004 ; 279: 49689-93
64. Guo Y., Guettouche T., Fenna M., Boellmann F., Pratt W. B., Toft D. O., Smith D. F., Voellmy R.. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem. 2001 ; 276: 45791-99
65. Gupta S., Deepti A., Deegan S., Lisbona F., Hetz C., Samali A.. HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS biology. 2010 ; 8: e1000410
66. Hagiwara S., Iwasaka H., Shingu C., Matsumoto S., Hasegawa A., Asai N., Noguchi T.. Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharide-induced endoplasmic reticulum stress. Intern J Hyperthermia. 2009 ; 25: 626-33
67. Hajnoczky G., Csordas G., Krishnamurthy R., Szalai G.. Mitochondrial calcium signaling driven by the IP3 receptor. J Bioenerg Biomembr. 2000 ; 32: 15-25
68. Han D., Lerner A. G., Vande Walle L., Upton J. P., Xu W., Hagen A., Backes B. J., Oakes S. A., Papa F. R.. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 ; 138: 562-75
69. Harding H. P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D.. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000 ; 6: 1099-108
70. Harding H. P., Zeng H., Zhang Y., Jungries R., Chung P., Plesken H., Sabatini D. D., Ron D.. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell. 2001 ; 7: 1153-63
71. Harding H. P., Zhang Y., Bertolotti A., Zeng H., Ron D.. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell. 2000 ; 5: 897-904
72. Harding H. P., Zhang Y., Ron D.. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 1999 ; 397: 271-74
73. Harding H. P., Zhang Y., Zeng H., Novoa I., Lu P. D., Calfon M., Sadri N., Yun C., Popko B., Paules R., Stojdl D. F., Bell J. C., Hettmann T., Leiden J. M., Ron D.. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003 ; 11: 619-33
74. Hayashi A., Kasahara T., Iwamoto K., Ishiwata M., Kametani M., Kakiuchi C., Furuichi T., Kato T.. The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. J Biol Chem. 2007 ; 282: 34525-34
75. Haynes C. M., Petrova K., Benedetti C., Yang Y., Ron D.. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell. 2007 ; 13: 467-80
76. Haynes C. M., Ron D.. The mitochondrial UPR-protecting organelle protein homeostasis. J Cell Sci. 2010 ; 123: 3849-55
77. Haynes C. M., Yang Y., Blais S. P., Neubert T. A., Ron D.. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell. 2010 ; 37: 529-40
78. Haze K., Yoshida H., Yanagi H., Yura T., Mori K.. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell. 1999 ; 10: 3787-99
79. Hetz C.. The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nature reviews. Mol Cell Biol. 2012 ; 13: 89-102
80. Hetz C., Bernasconi P., Fisher J., Lee A. H., Bassik M. C., Antonsson B., Brandt G. S., Iwakoshi N. N., Schinzel A., Glimcher L. H., Korsmeyer S. J.. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science. 2006 ; 312: 572-76
81. Hetz C., Glimcher L. H.. Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell. 2009 ; 35: 551-61
82. Hetz C., Russelakis-Carneiro M., Maundrell K., Castilla J., Soto C.. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 2003 ; 22: 5435-45
83. Hitomi J., Katayama T., Eguchi Y., Kudo T., Taniguchi M., Koyama Y., Manabe T., Yamagishi S., Bando Y., Imaizumi K., Tsujimoto Y., Tohyama M.. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol. 2004 ; 165: 347-56
84. Hollien J., Lin J. H., Li H., Stevens N., Walter P., Weissman J. S.. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009 ; 186: 323-31
85. Hollien J., Weissman J. S.. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 2006 ; 313: 104-107
86. Hoozemans J. J., van Haastert E. S., Nijholt D. A., Rozemuller A. J., Scheper W.. Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease. Neuro-degenerative Dis. 2012 ; 10: 212-15
87. Hu C. C., Dougan S. K., McGehee A. M., Love J. C., Ploegh H. L.. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009 ; 28: 1624-36
88. Hu J., Dang N., Menu E., De Bryune E., Xu D., Van Camp B., Van Valckenborgh E., Vanderkerken K.. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. Blood. 2012 ; 119: 826-37
89. Hu P., Han Z., Couvillon A. D., Kaufman R. J., Exton J. H.. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol. 2006 ; 26: 3071-84
90. Huh W. J., Esen E., Geahlen J. H., Bredemeyer A. J., Lee A. H., Shi G., Konieczny S. F., Glimcher L. H., Mills J. C.. XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology. 2010 ; 139: 2038-49
91. Imai Y., Soda M., Takahashi R.. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem. 2000 ; 275: 35661-64
92. Inagi R.. Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury. Nephron Exp Nephrol. 2009 ; 112: e1-9
93. Inagi R.. Endoplasmic reticulum stress as a progression factor for kidney injury. Curr Opin Pharmacol. 2010 ; 10: 156-65
94. Iqbal J., Dai K., Seimon T., Jungreis R., Oyadomari M., Kuriakose G., Ron D., Tabas I., Hussain M. M.. IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab. 2008 ; 7: 445-55
95. Ishikawa T., Watanabe N., Nagano M., Kawai-Yamada M., Lam E.. Bax inhibitor-1: A highly conserved endoplasmic reticulum-resident cell death suppressor. Cell Death Differ. 2011 ; 18: 1271-78
96. Iwakoshi N. N., Lee A. H., Glimcher L. H.. The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev. 2003 ; 194: 29-38
97. Iwawaki T., Akai R., Kohno K.. IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level. PLoS One. 2010 ; 5: e13052
98. Jaeschke H., Gores G. J., Cederbaum A. I., Hinson J. A., Pessayre D., Lemasters J. J.. Mechanisms of hepatotoxicity. Toxicol Sci. 2002 ; 65: 166-76
99. Jamora C., Dennert G., Lee A. S.. Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. Proc Natl Acad Sci USA. 1996 ; 93: 7690-94
100. Jousse C., Oyadomari S., Novoa I., Lu P., Zhang Y., Harding H. P., Ron D.. Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol. 2003 ; 163: 767-75
101. Julier C., Nicolino M.. Wolcott-Rallison syndrome. Orphanet journal of rare diseases. 2010 ; 5: 29
102. Kakiuchi C., Ishigaki S., Oslowski C. M., Fonseca S. G., Kato T., Urano F.. Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94. PLoS One. 2009 ; 4: e4134
103. Kakiuchi C., Iwamoto K., Ishiwata M., Bundo M., Kasahara T., Kusumi I., Tsujita T., Okazaki Y., Nanko S., Kunugi H., Sasaki T., Kato T.. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet. 2003 ; 35: 171-75
104. Kammoun H. L., Chabanon H., Hainault I., Luquet S., Magnan C., Koike T., Ferre P., Foufelle F.. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest. 2009 ; 119: 1201-15
105. Kang S. W., Rane N. S., Kim S. J., Garrison J. L., Taunton J., Hegde R. S.. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell. 2006 ; 127: 999-1013
106. Kao E., Shinohara M., Feng M., Lau M. Y., Ji C.. Human immunodeficiency virus protease inhibitors modulate Ca(2+) homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 ;:
107. Kaplowitz N., Than T. A., Shinohara M., Ji C.. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 ; 27: 367-77
108. Kapoor A., Sanyal A. J.. Endoplasmic reticulum stress and the unfolded protein response. Clin Liver Dis. 2009 ; 13: 581-90
109. Katayama T., Imaizumi K., Sato N., Miyoshi K., Kudo T., Hitomi J., Morihara T., Yoneda T., Gomi F., Mori Y., Nakano Y., Takeda J., Tsuda T., Itoyama Y., Murayama O., Takashima A., St George-Hyslop P., Takeda M., Tohyama M.. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol. 1999 ; 1: 479-85
110. Kato H., Nakajima S., Saito Y., Takahashi S., Katoh R., Kitamura M.. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell Death Differ. 2012 ; 19: 310-20
111. Kaufman R. J.. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev. 1999 ; 13: 1211-33
112. Kaufman R. J., Scheuner D., Schroder M., Shen X., Lee K., Liu C. Y., Arnold S. M.. The unfolded protein response in nutrient sensing and differentiation. Nature reviews. Mol Cell Biol. 2002 ; 3: 411-21
113. Kim A. J., Shi Y., Austin R. C., Werstuck G. H.. Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci. 2005 ; 118: 89-99
114. Kim I., Xu W., Reed J. C.. Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities. Nature reviews. Drug Discov. 2008 ; 7: 1013-30
115. Kim P. S., Arvan P.. Hormonal regulation of thyroglobulin export from the endoplasmic reticulum of cultured thyrocytes. J Biol Chem. 1993 ; 268: 4873-79
116. Kimball S. R.. Regulation of translation initiation by amino acids in eukaryotic cells. Prog Mol Subcell Biol. 2001 ; 26: 155-84
117. Kitamura M.. Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces. Am J Physiol Renal Physiol. 2008 ; 295: F323-34
118. Kondo S., Murakami T., Tatsumi K., Ogata M., Kanemoto S., Otori K., Iseki K., Wanaka A., Imaizumi K.. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol. 2005 ; 7: 186-94
119. Kondo S., Saito A., Hino S., Murakami T., Ogata M., Kanemoto S., Nara S., Yamashita A., Yoshinaga K., Hara H., Imaizumi K.. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol Cell Biol. 2007 ; 27: 1716-29
120. Kouroku Y., Fujita E., Jimbo A., Kikuchi T., Yamagata T., Momoi M. Y., Kominami E., Kuida K., Sakamaki K., Yonehara S., Momoi T.. Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Human Mol Genet. 2002 ; 11: 1505-15
121. Kouroku Y., Fujita E., Tanida I., Ueno T., Isoai A., Kumagai H., Ogawa S., Kaufman R. J., Kominami E., Momoi T.. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 2007 ; 14: 230-39
122. Kraus M., Malenke E., Gogel J., Muller H., Ruckrich T., Overkleeft H., Ovaa H., Koscielniak E., Hartmann J. T., Driessen C.. Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis. Mol Cancer Ther. 2008 ; 7: 1940-48
123. Kudo T., Kanemoto S., Hara H., Morimoto N., Morihara T., Kimura R., Tabira T., Imaizumi K., Takeda M.. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008 ; 15: 364-75
124. Kumar R., Azam S., Sullivan J. M., Owen C., Cavener D. R., Zhang P., Ron D., Harding H. P., Chen J. J., Han A., White B. C., Krause G. S., DeGracia D. J.. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem. 2001 ; 77: 1418-21
125. Kurokawa M., Kornbluth S.. Caspases and kinases in a death grip. Cell. 2009 ; 138: 838-54
126. Ladriere L., Igoillo-Esteve M., Cunha D. A., Brion J. P., Bugliani M., Marchetti P., Eizirik D. L., Cnop M.. Enhanced signaling downstream of ribonucleic acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets. J Clin Endocrinol Metab. 2010 ; 95: 1442-49
127. Lanner J. T., Georgiou D. K., Joshi A. D., Hamilton S. L.. Ryanodine receptors: Structure, expression, molecular details, and function in calcium release. Cold Spring Harbor Perspec Biol. 2010 ; 2: a003996
128. Latreille M., Larose L.. Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. J Biol Chem. 2006 ; 281: 26633-44
129. Laybutt D. R., Preston A. M., Akerfeldt M. C., Kench J. G., Busch A. K., Biankin A. V., Biden T. J.. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia. 2007 ; 50: 752-63
130. Lee A. H., Chu G. C., Iwakoshi N. N., Glimcher L. H.. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J. 2005 ; 24: 4368-80
131. Lee A. H., Iwakoshi N. N., Anderson K. C., Glimcher L. H.. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci USA. 2003 ; 100: 9946-51
132. Lee A. H., Iwakoshi N. N., Glimcher L. H.. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol. 2003 ; 23: 7448-59
133. Lee A. H., Scapa E. F., Cohen D. E., Glimcher L. H.. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 2008 ; 320: 1492-96
134. Lee J., Sun C., Zhou Y., Gokalp D., Herrema H., Park S. W., Davis R. J., Ozcan U.. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med. 2011 ; 17: 1251-60
135. Lee K., Tirasophon W., Shen X., Michalak M., Prywes R., Okada T., Yoshida H., Mori K., Kaufman R. J.. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002 ; 16: 452-66
136. Lemin A. J., Saleki K., van Lith M., Benham A. M.. Activation of the unfolded protein response and alternative splicing of ATF6alpha in HLA-B27 positive lymphocytes. FEBS Lett. 2007 ; 581: 1819-1824
137. Levine B., Kroemer G.. Autophagy in the pathogenesis of disease. Cell. 2008 ; 132: 27-42
138. Li B., Gao B., Ye L., Han X., Wang W., Kong L., Fang X., Zeng Y., Zheng H., Li S., Wu Z.. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res. 2007 ; 124: 44-49
139. Li F., Hayashi T., Jin G., Deguchi K., Nagotani S., Nagano I., Shoji M., Chan P. H., Abe K.. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Brain Res. 2005 ; 1048: 59-68
140. Li G., Mongillo M., Chin K. T., Harding H., Ron D., Marks A. R., Tabas I.. Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol. 2009 ; 186: 783-92
141. Li H., Korennykh A. V., Behrman S. L., Walter P.. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci USA. 2010 ; 107: 16113-18
142. Li Y., Schwabe R. F., DeVries-Seimon T., Yao P. M., Gerbod-Giannone M. C., Tall A. R., Davis R. J., Flavell R., Brenner D. A., Tabas I.. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: Model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005b ; 280: 21763-72
143. Lin J. H., Li H., Yasumura D., Cohen H. R., Zhang C., Panning B., Shokat K. M., Lavail M. M., Walter P.. IRE1 signaling affects cell fate during the unfolded protein response. Science. 2007 ; 318: 944-49
144. Lin J. H., Li H., Zhang Y., Ron D., Walter P.. Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One. 2009 ; 4: e4170
145. Lisbona F., Rojas-Rivera D., Thielen P., Zamorano S., Todd D., Martinon F., Glavic A., Kress C., Lin J. H., Walter P., Reed J. C., Glimcher L. H., Hetz C.. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell. 2009 ; 33: 679-91
146. Liu B. Q., Gao Y. Y., Niu X. F., Xie J. S., Meng X., Guan Y., Wang H. Q.. Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation. Biochem Biophys Res Commun. 2010 ; 391: 778-82
147. Liu H., Bowes R. C., van de Water B., Sillence C., Nagelkerke J. F., Stevens J. L.. Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells. J Biol Chem. 1997 ; 272: 21751-59
148. Liu H., Zhao S., Zhang Y., Wu J., Peng H., Fan J., Liao J.. Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells. J Cell Biochem. 2011 ; 112: 3695-703
149. Lum P. Y., He Y. D., Slatter J. G., Waring J. F., Zelinsky N., Cavet G., Dai X., Fong O., Gum R., Jin L., Adamson G. E., Roberts C. J., Olsen D. B.,
150. Luo D., He Y., Zhang H., Yu L., Chen H., Xu Z., Tang S., Urano F., Min W.. AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem. 2008 ; 283: 11905-912
151. Ma Y., Brewer J. W., Diehl J. A., Hendershot L. M.. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol. 2002 ; 318: 1351-65
152. Ma Y., Hendershot L. M.. Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J Biol Chem. 2003 ; 278: 34864-73
153. Ma Y., Hendershot L. M.. ER chaperone functions during normal and stress conditions. J Chem Neuroanat. 2004 ; 28: 51-65
154. Ma Y., Shimizu Y., Mann M. J., Jin Y., Hendershot L. M.. Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response. Cell Stress Chaperones. 2010 ; 15: 281-93
155. Malhi H., Kaufman R. J.. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011 ; 54: 795-809
156. Malhotra J. D., Kaufman R. J.. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol. 2007 ; 18: 716-31
157. Malhotra J. D., Miao H., Zhang K., Wolfson A., Pennathur S., Pipe S. W., Kaufman R. J.. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci USA. 2008 ; 105: 18525-30
158. Marciniak S. J., Yun C. Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R., Nagata K., Harding H. P., Ron D.. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004 ; 18: 3066-77
159. Marcu M. G., Doyle M., Bertolotti A., Ron D., Hendershot L., Neckers L.. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol Cell Biol. 2002 ; 22: 8506-13
160. Markan S., Kohli H. S., Joshi K., Minz R. W., Sud K., Ahuja M., Anand S., Khullar M.. Up regulation of the GRP-78 and GADD-153 and down regulation of Bcl-2 proteins in primary glomerular diseases: A possible involvement of the ER stress pathway in glomerulonephritis. Mol Cell Biochem. 2009 ; 324: 131-38
161. Martinon F., Chen X., Lee A. H., Glimcher L. H.. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol. 2010 ; 11: 411-18
162. McCullough K. D., Martindale J. L., Klotz L. O., Aw T. Y., Holbrook N. J.. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol. 2001 ; 21: 1249-59
163. Michelangeli F., East J. M.. A diversity of SERCA Ca2+ pump inhibitors. Biochem Soc Trans. 2011 ; 39: 789-97
164. Milhavet O., Martindale J. L., Camandola S., Chan S. L., Gary D. S., Cheng A., Holbrook N. J., Mattson M. P.. Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations. J Neurochem. 2002 ; 83: 673-81
165. Miller P. F., Hinnebusch A. G. cis-acting sequences involved in the translational control of GCN4 expression. Biochim Biophys Acta. 1990 1050 ;: 151-54
166. Morishima N., Nakanishi K., Takenouchi H., Shibata T., Yasuhiko Y.. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem. 2002 ; 277: 34287-94
167. Mosser D. D., Kotzbauer P. T., Sarge K. D., Morimoto R. I.. In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proc Natl Acad Sci USA. 1990 ; 87: 3748-52
168. Nakagawa T., Yuan J.. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol. 2000 ; 150: 887-94
169. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B. A., Yuan J.. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 ; 403: 98-103
170. Nakka V. P., Gusain A., Raghubir R.. Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats. Neurotox Res. 2010 ; 17: 189-202
171. Navarro V. J., Senior J. R.. Drug-related hepatotoxicity. N Engl J Med. 2006 ; 354: 731-39
172. Nawrocki S. T., Carew J. S., Dunner K., Boise L. H., Chiao P. J., Huang P., Abbruzzese J. L., McConkey D. J.. Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Res. 2005 ; 65: 11510-19
173. Nawrocki S. T., Carew J. S., Pino M. S., Highshaw R. A., Dunner K., Huang P., Abbruzzese J. L., McConkey D. J.. Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res. 2005 ; 65: 11658-66
174. Neupert W.. Protein import into mitochondria. Ann Rev Biochem. 1997 ; 66: 863-917
175. Neupert W., Herrmann J. M.. Translocation of proteins into mitochondria. Ann Rev Biochem. 2007 ; 76: 723-49
176. Nishitoh H., Kadowaki H., Nagai A., Maruyama T., Yokota T., Fukutomi H., Noguchi T., Matsuzawa A., Takeda K., Ichijo H.. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev. 2008 ; 22: 1451-64
177. Nishitoh H., Matsuzawa A., Tobiume K., Saegusa K., Takeda K., Inoue K., Hori S., Kakizuka A., Ichijo H.. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 2002 ; 16: 1345-55
178. Niwa M., Sidrauski C., Kaufman R. J., Walter P.. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell. 1999 ; 99: 691-702
179. Obeng E. A., Carlson L. M., Gutman D. M., Harrington W. J., Lee K. P., Boise L. H.. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood. 2006 ; 107: 4907-16
180. Ogata M., Hino S., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., Shiosaka S., Hammarback J. A., Urano F., Imaizumi K.. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol. 2006 ; 26: 9220-31
181. Oono K., Yoneda T., Manabe T., Yamagishi S., Matsuda S., Hitomi J., Miyata S., Mizuno T., Imaizumi K., Katayama T., Tohyama M.. JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Neurochem Int. 2004 ; 45: 765-72
182. Oslowski C. M., Urano F.. Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol. 2011 ; 490: 71-92
183. Ota A., Wang Y.. Cdc37/Hsp90 protein-mediated regulation of IRE1alpha protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. J Biol Chem. 2012 ; 287: 6266-74
184. Oyadomari S., Harding H. P., Zhang Y., Oyadomari M., Ron D.. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 2008 ; 7: 520-32
185. Oyadomari S., Mori M.. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004 ; 11: 381-89
186. Oyadomari S., Yun C., Fisher E. A., Kreglinger N., Kreibich G., Oyadomari M., Harding H. P., Goodman A. G., Harant H., Garrison J. L., Taunton J., Katze M. G., Ron D.. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 2006 ; 126: 727-39
187. Ozcan L., Tabas I.. Role of endoplasmic reticulum stress in metabolic disease and other disorders. Ann Rev Med. 2012 ; 63: 317-28
188. Ozcan U., Cao Q., Yilmaz E., Lee A. H., Iwakoshi N. N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L. H., Hotamisligil G. S.. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004 ; 306: 457-61
189. Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R. O., Gorgun C. Z., Hotamisligil G. S.. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006 ; 313: 1137-40
190. Pallet N., Bouvier N., Bendjallabah A., Rabant M., Flinois J. P., Hertig A., Legendre C., Beaune P., Thervet E., Anglicheau D.. Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death. Am J Transplant. 2008 ; 8: 2283-96
191. Papandreou I., Denko N. C., Olson M., Van Melckebeke H., Lust S., Tam A., Solow-Cordero D. E., Bouley D. M., Offner F., Niwa M., Koong A. C.. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 ; 117: 1311-14
192. Park H. R., Tomida A., Sato S., Tsukumo Y., Yun J., Yamori T., Hayakawa Y., Tsuruo T., Shin-ya K.. Effect on tumor cells of blocking survival response to glucose deprivation. J Nat Canc Inst. 2004 ; 96: 1300-10
193. Park H. S., Jun do Y., Han C. R., Woo H. J., Kim Y. H.. Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells. Biochem Pharmacol. 2011 ; 82: 1110-25
194. Park S. W., Zhou Y., Lee J., Lu A., Sun C., Chung J., Ueki K., Ozcan U.. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med. 2010 ; 16: 429-37
195. Parmar V. M., Schroder M.. Sensing endoplasmic reticulum stress. Adv Exp Med Biol. 2012 ; 738: 153-68
196. Pattingre S., Bauvy C., Carpentier S., Levade T., Levine B., Codogno P.. Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem. 2009 ; 284: 2719-28
197. Pavio N., Romano P. R., Graczyk T. M., Feinstone S. M., Taylor D. R.. Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK. J Virol. 2003 ; 77: 3578-85
198. Petrucelli L., O'Farrell C., Lockhart P. J., Baptista M., Kehoe K., Vink L., Choi P., Wolozin B., Farrer M., Hardy J., Cookson M. R.. Parkin protects against the toxicity associated with mutant alpha-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 2002 ; 36: 1007-19
199. Peyrou M., Cribb A. E.. Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines. Toxicol In Vitro. 2007 ; 21: 878-86
200. Putcha G. V., Le S., Frank S., Besirli C. G., Clark K., Chu B., Alix S., Youle R. J., LaMarche A., Maroney A. C., Johnson E. M.,. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron. 2003 ; 38: 899-914
201. Puthalakath H., O'Reilly L. A., Gunn P., Lee L., Kelly P. N., Huntington N. D., Hughes P. D., Michalak E. M., McKimm-Breschkin J., Motoyama N., Gotoh T., Akira S., Bouillet P., Strasser A.. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell. 2007 ; 129: 1337-49
202. Pyrko P., Kardosh A., Wang W., Xiong W., Schonthal A. H., Chen T. C.. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 2007 ; 67: 10920-28
203. Qiu Y., Mao T., Zhang Y., Shao M., You J., Ding Q., Chen Y., Wu D., Xie D., Lin X., Gao X., Kaufman R. J., Li W., Liu Y.. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal. 2010 ; 3: ra7
204. Quinones Q. J., de Ridder G. G., Pizzo S. V.. GRP78: A chaperone with diverse roles beyond the endoplasmic reticulum. Histol Histopathol. 2008 ; 23: 1409-16
205. Quiros Y., Vicente-Vicente L., Morales A. I., Lopez-Novoa J. M., Lopez-Hernandez F. J.. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol Sci. 2011 ; 119: 245-56
206. Rahmani M., Davis E. M., Crabtree T. R., Habibi J. R., Nguyen T. K., Dent P., Grant S.. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol. 2007 ; 27: 5499-513
207. Rao R. V., Hermel E., Castro-Obregon S., del Rio G., Ellerby L. M., Ellerby H. M., Bredesen D. E.. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem. 2001 ; 276: 33869-74
208. Rasola A., Bernardi P.. Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. Cell Calcium. 2011 ; 50: 222-33
209. Reijonen S., Putkonen N., Norremolle A., Lindholm D., Korhonen L.. Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins. Exp Cell Res. 2008 ; 314: 950-60
210. Rizzuto R., Marchi S., Bonora M., Aguiari P., Bononi A., De Stefani D., Giorgi C., Leo S., Rimessi A., Siviero R., Zecchini E., Pinton P.. Ca(2+) transfer from the ER to mitochondria: When, how and why. Biochim Biophy Acta. 2009 ; 1787: 1342-51
211. Robinson K. S., Clements A., Williams A. C., Berger C. N., Frankel G.. Bax inhibitor 1 in apoptosis and disease. Oncogene. 2011 ; 30: 2391-400
212. Ruddock L. W., Molinari M.. N-glycan processing in ER quality control. J Cell Sci. 2006 ; 119: 4373-80
213. Ruiz-Vela A., Opferman J. T., Cheng E. H., Korsmeyer S. J.. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Reports. 2005 ; 6: 379-85
214. Rutkowski D. T., Arnold S. M., Miller C. N., Wu J., Li J., Gunnison K. M., Mori K., Sadighi Akha A. A., Raden D., Kaufman R. J.. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006 ; 4: e374
215. Rutkowski D. T., Wu J., Back S. H., Callaghan M. U., Ferris S. P., Iqbal J., Clark R., Miao H., Hassler J. R., Fornek J., Katze M. G., Hussain M. M., Song B., Swathirajan J., Wang J., Yau G. D., Kaufman R. J.. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell. 2008 ; 15: 829-40
216. Ryu E. J., Harding H. P., Angelastro J. M., Vitolo O. V., Ron D., Greene L. A.. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci. 2002 ; 22: 10690-98
217. Rzymski T., Milani M., Pike L., Buffa F., Mellor H. R., Winchester L., Pires I., Hammond E., Ragoussis I., Harris A. L.. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene. 2010 ; 29: 4424-35
218. Rzymski T., Milani M., Singleton D. C., Harris A. L.. Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell Cycle. 2009 ; 8: 3838-47
219. Saleh M., Vaillancourt J. P., Graham R. K., Huyck M., Srinivasula S. M., Alnemri E. S., Steinberg M. H., Nolan V., Baldwin C. T., Hotchkiss R. S., Buchman T. G., Zehnbauer B. A., Hayden M. R., Farrer L. A., Roy S., Nicholson D. W.. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 2004 ; 429: 75-79
220. Salvesen G. S., Dixit V. M.. Caspases: Intracellular signaling by proteolysis. Cell. 1997 ; 91: 443-46
221. Sandqvist A., Bjork J. K., Akerfelt M., Chitikova Z., Grichine A., Vourc'h C., Jolly C., Salminen T. A., Nymalm Y., Sistonen L.. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell. 2009 ; 20: 1340-47
222. Sanson M., Auge N., Vindis C., Muller C., Bando Y., Thiers J. C., Marachet M. A., Zarkovic K., Sawa Y., Salvayre R., Negre-Salvayre A.. Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: Prevention by oxygen-regulated protein 150 expression. Circ Res. 2009 ; 104: 328-36
223. Sargsyan E., Baryshev M., Mkrtchian S.. The physiological unfolded protein response in the thyroid epithelial cells. Biochem Biophys Res Commun. 2004 ; 322: 570-76
224. Sargsyan E., Baryshev M., Szekely L., Sharipo A., Mkrtchian S.. Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex. J Biol Chem. 2002 ; 277: 17009-15
225. Sarkar S., Perlstein E. O., Imarisio S., Pineau S., Cordenier A., Maglathlin R. L., Webster J. A., Lewis T. A., O'Kane C. J., Schreiber S. L., Rubinsztein D. C.. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 ; 3: 331-38
226. Saxena S., Cabuy E., Caroni P.. A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat Neurosci. 2009 ; 12: 627-36
227. Scheuner D., Song B., McEwen E., Liu C., Laybutt R., Gillespie P., Saunders T., Bonner-Weir S., Kaufman R. J.. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001 ; 7: 1165-76
228. Scheuner D., Vander Mierde D., Song B., Flamez D., Creemers J. W., Tsukamoto K., Ribick M., Schuit F. C., Kaufman R. J.. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med. 2005 ; 11: 757-64
229. Schmidtke G., Holzhutter H. G., Bogyo M., Kairies N., Groll M., de Giuli R., Emch S., Groettrup M.. How an inhibitor of the HIV-I protease modulates proteasome activity. The J Biol Chem. 1999 ; 274: 35734-40
230. Schroder M., Kaufman R. J.. The mammalian unfolded protein response. Ann Rev Biochem. 2005 ; 74: 739-89
231. Scull C. M., Tabas I.. Mechanisms of ER stress-induced apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 ; 31: 2792-97
232. Shamovsky I., Ivannikov M., Kandel E. S., Gershon D., Nudler E.. RNA-mediated response to heat shock in mammalian cells. Nature. 2006 ; 440: 556-60
233. Shao L., Sun X., Xu L., Young L. T., Wang J. F.. Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. Life Sci. 2006 ; 78: 1317-23
234. Shi Y., Gerritsma D., Bowes A. J., Capretta A., Werstuck G. H.. Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition. Bioorg Med Chem Lett. 2007 ; 17: 4491-94
235. Shimazaki H., Watanabe K., Veeraveedu P. T., Harima M., Thandavarayan R. A., Arozal W., Tachikawa H., Kodama M., Aizawa Y.. The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis. Free Radic Res. 2010 ; 44: 1082-90
236. Shintani-Ishida K., Nakajima M., Uemura K., Yoshida K.. Ischemic preconditioning protects cardiomyocytes against ischemic injury by inducing GRP78. Biochem Biophys Res Commun. 2006 ; 345: 1600-05
237. Shuda M., Kondoh N., Imazeki N., Tanaka K., Okada T., Mori K., Hada A., Arai M., Wakatsuki T., Matsubara O., Yamamoto N., Yamamoto M.. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol. 2003 ; 38: 605-14
238. Silva M. F., Aires C. C., Luis P. B., Ruiter J. P., Ijlst L., Duran M., Wanders R. J., Tavares de Almeida I.. Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review. J Inherit Metab Dis. 2008 ; 31: 205-16
239. Simmen T., Lynes E. M., Gesson K., Thomas G.. Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM). Biochim Biophys Acta. 2010 ; 1798: 1465-73
240. Smith M. H., Ploegh H. L., Weissman J. S.. Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum. Science. 2011 ; 334: 1086-90
241. Smith W. W., Jiang H., Pei Z., Tanaka Y., Morita H., Sawa A., Dawson V. L., Dawson T. M., Ross C. A.. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Human Mol Genet. 2005 ; 14: 3801-11
242. Sokka A. L., Putkonen N., Mudo G., Pryazhnikov E., Reijonen S., Khiroug L., Belluardo N., Lindholm D., Korhonen L.. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J Neurosci. 2007 ; 27: 901-908
243. Song B., Scheuner D., Ron D., Pennathur S., Kaufman R. J.. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest. 2008 ; 118: 3378-89
244. Song L., De Sarno P., Jope R. S.. Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J Biol Chem. 2002 ; 277: 44701-08
245. Stirling J., O'Hare P.. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. Mol Biol Cell. 2006 ; 17: 413-26
246. Tajiri S., Oyadomari S., Yano S., Morioka M., Gotoh T., Hamada J. I., Ushio Y., Mori M.. Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death Differ. 2004 ; 11: 403-15
247. Tamaki N., Hatano E., Taura K., Tada M., Kodama Y., Nitta T., Iwaisako K., Seo S., Nakajima A., Ikai I., Uemoto S.. CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury. Am J Physiol Gastrointest Liver Physiol. 2008 ; 294: G498-505
248. Tan Y., Dourdin N., Wu C., De Veyra T., Elce J. S., Greer P. A.. Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. J Biol Chem. 2006 ; 281: 16016-24
249. Tanaka S., Uehara T., Nomura Y.. Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death. J Biol Chem. 2000 ; 275: 10388-93
250. Tanaka Y., Engelender S., Igarashi S., Rao R. K., Wanner T., Tanzi R. E., Sawa A. V. L. D., Dawson T. M., Ross C. A.. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human Mol Genet. 2001 ; 10: 919-26
251. Tardif K. D., Mori K., Kaufman R. J., Siddiqui A.. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem. 2004 ; 279: 17158-64
252. Tatsuta T., Langer T.. Quality control of mitochondria: Protection against neurodegeneration and ageing. EMBO J. 2008 ; 27: 306-14
253. Teske B. F., Baird T. D., Wek R. C.. Methods for analyzing eIF2 kinases and translational control in the unfolded protein response. Methods Enzymol. 2011 ; 490: 333-56
254. Thuerauf D. J., Marcinko M., Gude N., Rubio M., Sussman M. A., Glembotski C. C.. Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res. 2006 ; 99: 275-82
255. Tirasophon W., Welihinda A. A., Kaufman R. J.. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 1998 ; 12: 1812-24
256. Toth A., Nickson P., Mandl A., Bannister M. L., Toth K., Erhardt P.. Endoplasmic reticulum stress as a novel therapeutic target in heart diseases. Cardiovasc Hematol Disord Drug Targets. 2007 ; 7: 205-18
257. Tsaytler P., Harding H. P., Ron D., Bertolotti A.. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science. 2011 ; 332: 91-94
258. Tsutsumi S., Gotoh T., Tomisato W., Mima S., Hoshino T., Hwang H. J., Takenaka H., Tsuchiya T., Mori M., Mizushima T.. Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis. Cell Death Differ. 2004 ; 11: 1009-16
259. Tsutsumi S., Namba T., Tanaka K. I., Arai Y., Ishihara T., Aburaya M., Mima S., Hoshino T., Mizushima T.. Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells. Oncogene. 2006 ; 25: 1018-29
260. Tu B. P., Weissman J. S.. Oxidative protein folding in eukaryotes: Mechanisms and consequences. J Cell Biol. 2004 ; 164: 341-46
261. Ubeda M., Vallejo M., Habener J. F.. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol. 1999 ; 19: 7589-99
262. Unterberger U., Hoftberger R., Gelpi E., Flicker H., Budka H., Voigtlander T.. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J Neuropathol Exp Neurol. 2006 ; 65: 348-57
263. Urano F., Bertolotti A., Ron D.. IRE1 and efferent signaling from the endoplasmic reticulum. J Cell Sci. 2000 ; 113 (Pt 21). 3697-702
264. Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H. P., Ron D.. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 2000 ; 287: 664-66
265. van Anken E., Romijn E. P., Maggioni C., Mezghrani A., Sitia R., Braakman I., Heck A. J.. Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity. 2003 ; 18: 243-53
266. van Huizen R., Martindale J. L., Gorospe M., Holbrook N. J.. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J Biol Chem. 2003 ; 278: 15558-64
267. Vecchi C., Montosi G., Zhang K., Lamberti I., Duncan S. A., Kaufman R. J., Pietrangelo A.. ER stress controls iron metabolism through induction of hepcidin. Science. 2009 ; 325: 877-80
268. Vilatoba M., Eckstein C., Bilbao G., Smyth C. A., Jenkins S., Thompson J. A., Eckhoff D. E., Contreras J. L.. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery. 2005 ; 138: 342-51
269. Walter P., Ron D.. The unfolded protein response: From stress pathway to homeostatic regulation. Science. 2011 ; 334: 1081-86
270. Wang F. M., Chen Y. J., Ouyang H. J.. Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem J. 2011 ; 433: 245-52
271. Wang F. M., Galson D. L., Roodman G. D., Ouyang H.. Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells. Exp Hematol. 2011 ; 39: 999-1006
272. Wang Q., Mora-Jensen H., Weniger M. A., Perez-Galan P., Wolford C., Hai T., Ron D., Chen W., Trenkle W., Wiestner A., Ye Y.. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci USA. 2009 ; 106: 2200-05
273. Wang Q., Shinkre B. A., Lee J. G., Weniger M. A., Liu Y., Chen W., Wiestner A., Trenkle W. C., Ye Y.. The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group. PLoS One. 2010 ; 5: e15479
274. Wang X. Z., Ron D.. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science. 1996 ; 272: 1347-49
275. Wang Y., Vera L., Fischer W. H., Montminy M.. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature. 2009b ; 460: 534-37
276. Wiest D. L., Burkhardt J. K., Hester S., Hortsch M., Meyer D. I., Argon Y.. Membrane biogenesis during B cell differentiation: Most endoplasmic reticulum proteins are expressed coordinately. J Cell Biol. 1990 ; 110: 1501-11
277. Woo C. W., Cui D., Arellano J., Dorweiler B., Harding H., Fitzgerald K. A., Ron D., Tabas I.. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol. 2009 ; 11: 1473-80
278. Wu C. T., Sheu M. L., Tsai K. S., Chiang C. K., Liu S. H.. Salubrinal, an eIF2alpha dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model. Free Rad Biol Med. 2011 ; 51: 671-80
279. Wu J., Rutkowski D. T., Dubois M., Swathirajan J., Saunders T., Wang J., Song B., Yau G. D., Kaufman R. J.. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell. 2007 ; 13: 351-64
280. Xu C., Bailly-Maitre B., Reed J. C.. Endoplasmic reticulum stress: Cell life and death decisions. J Clin Invest. 2005 ; 115: 2656-64
281. Xu X., Gupta S., Hu W., McGrath B. C., Cavener D. R.. Hyperthermia induces the ER stress pathway. PLoS One. 2011 ; 6: e23740
282. Xu Z., Jensen G., Yen T. S.. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol. 1997 ; 71: 7387-92
283. Yamada T., Ishihara H., Tamura A., Takahashi R., Yamaguchi S., Takei D., Tokita A., Satake C., Tashiro F., Katagiri H., Aburatani H., Miyazaki J., Oka Y.. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Human Mol Genet. 2006 ; 15: 1600-09
284. Yamaguchi H., Wang H. G.. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem. 2004 ; 279: 45495-502
285. Yamaguchi Y., Larkin D., Lara-Lemus R., Ramos-Castaneda J., Liu M., Arvan P.. Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK. J Biol Chem. 2008 ; 283: 17020-29
286. Yamamoto K., Ichijo H., Korsmeyer S. J.. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol. 1999 ; 19: 8469-78
287. Yamamoto K., Sato T., Matsui T., Sato M., Okada T., Yoshida H., Harada A., Mori K.. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell. 2007 ; 13: 365-76
288. Yamamoto K., Takahara K., Oyadomari S., Okada T., Sato T., Harada A., Mori K.. Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell. 2010 ; 21: 2975-86
289. Yan W., Frank C. L., Korth M. J., Sopher B. L., Novoa I., Ron D., Katze M. G.. Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci USA. 2002 ; 99: 15920-25
290. Yanagitani K., Imagawa Y., Iwawaki T., Hosoda A., Saito M., Kimata Y., Kohno K.. Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. Mol Cell. 2009 ; 34: 191-200
291. Yavari M., Brinkley G., Klapstein K. D., Hartwig W. C., Rao R., Hermel E.. Presence of the functional CASPASE-12 allele in Indian subpopulations. Int J Immunogenet. 2012 ;:
292. Yoneda T., Imaizumi K., Oono K., Yui D., Gomi F., Katayama T., Tohyama M.. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem. 2001 ; 276: 13935-40
293. Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K.. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2001 ; 107: 881-91
294. Yoshida H., Okada T., Haze K., Yanagi H., Yura T., Negishi M., Mori K.. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol. 2000 ; 20: 6755-67
295. Yoshida H., Oku M., Suzuki M., Mori K.. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol. 2006 ; 172: 565-75
296. Yoshida H., Uemura A., Mori K.. pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation. Cell Struct Funct. 2009 ; 34: 1-10
297. Younce C. W., Kolattukudy P. E.. MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP. Biochem J. 2010 ; 426: 43-53
298. Zhang C., Kawauchi J., Adachi M. T., Hashimoto Y., Oshiro S., Aso T., Kitajima S.. Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun. 2001 ; 289: 718-24
299. Zhang K.. Integration of ER stress, oxidative stress and the inflammatory response in health and disease. Int J Clin Exp Med. 2010 ; 3: 33-40
300. Zhang K., Kaufman R. J.. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008 ; 454: 455-62
301. Zhang K., Shen X., Wu J., Sakaki K., Saunders T., Rutkowski D. T., Back S. H., Kaufman R. J.. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 2006 ; 124: 587-99
302. Zhang K., Wang S., Malhotra J., Hassler J. R., Back S. H., Wang G., Chang L., Xu W., Miao H., Leonardi R., Chen Y. E., Jackowski S., Kaufman R. J.. The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. EMBO J. 2011 ; 30: 1357-75
303. Zhang L., Yu J., Pan H., Hu P., Hao Y., Cai W., Zhu H., Yu A. D., Xie X., Ma D., Yuan J.. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci USA. 2007 ; 104: 19023-28
304. Zhang P. L., Lun M., Teng J., Huang J., Blasick T. M., Yin L., Herrera G. A., Cheung J. Y.. Preinduced molecular chaperones in the endoplasmic reticulum protect cardiomyocytes from lethal injury. Ann Clin Lab Sci. 2004 ; 34: 449-57
305. Zheng Z., Zhang C., Zhang K.. Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. Methods Enzymol. 2011 ; 489: 329-48
306. Zhou Y., Lee J., Reno C. M., Sun C., Park S. W., Chung J., Fisher S. J., White M. F., Biddinger S. B., Ozcan U.. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 ; 17: 356-65
307. Zinszner H., Kuroda M., Wang X., Batchvarova N., Lightfoot R. T., Remotti