The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress

Molecular and Cellular Biology

Volumn 27, Issue 15, 2007, Pages 5499-5513

  Rahmani, Mohamed ^a   Davis, Eric Maynard ^a   Crabtree, Timothy Ryan ^a   Habibi, Joseph Reza ^a   Nguyen, Tri K ^a   Dent, Paul ^a   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CASPASE 2; CASPASE 4; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; INITIATION FACTOR 2ALPHA; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NUCLEIC ACID BINDING PROTEIN; PHOSPHOTRANSFERASE; PKR LIKE ER KINASE; PROTEIN MCL 1; SMALL INTERFERING RNA; SORAFENIB; SULFUR 35; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ARTICLE; CALCIUM MOBILIZATION; CELL DEATH; CELL PROTECTION; CELL STRAIN K 562; CELL STRAIN U937; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; STRESS;

ANIMALS; BENZENESULFONATES; CALCIUM SIGNALING; CASPASE 2; CASPASES, INITIATOR; CELL DEATH; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INDUCTION; EUKARYOTIC INITIATION FACTOR-2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; PROTEIN KINASE INHIBITORS; PYRIDINES; REACTIVE OXYGEN SPECIES; RNA SPLICING;

EUKARYOTA;

EID: 34547197343     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01080-06     Document Type: Article

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