Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo

Toxicological Sciences

Volumn 88, Issue 2, 2005, Pages 576-584

  Asmellash, Senait ^a,e   Stevens, James L ^b   Ichimura, Takaharu ^c,d  

^a CLARKSON UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e The University of Alabama at Birmingham   (United States)

Author keywords

ER stress; Grp78; Nephrotoxicant; Renal injury; S (1,1,2,2, tetrafluoroethyl) L cysteine (TFEC); Trans 4,5 dihydroxy 1,2 dithiane (DTTox)

Indexed keywords

1,2 DITHIANE 4,5 DIOL; AMPHETAMINE; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN; PROTECTIVE AGENT; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL INJURY; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY INJURY; KIDNEY TUBULE EPITHELIUM; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; STRESS; TOXICITY TESTING;

ANIMALS; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HETEROCYCLIC COMPOUNDS; HSP70 HEAT-SHOCK PROTEINS; HYDROCARBONS, FLUORINATED; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MALE; MOLECULAR CHAPERONES; OXIDATIVE STRESS; RATS; RATS, INBRED F344; RNA, ANTISENSE;

ANIMALIA;

EID: 27944432606     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi303     Document Type: Article

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