Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

Science

Volumn 332, Issue 6025, 2011, Pages 91-94

  Tsaytler, Pavel ^a   Harding, Heather P ^b   Ron, David ^b   Bertolotti, Anne ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; GUANABENZ; INITIATION FACTOR 2ALPHA; PHOSPHOPROTEIN PHOSPHATASE 1; TUNICAMYCIN;

BIOLOGICAL ANALYSIS; CATALYSIS; CELL ORGANELLE; DRUG; ENZYME ACTIVITY; INHIBITION; MOLECULAR ANALYSIS; PROTEIN;

ARTICLE; CELL PROTECTION; CELL STRESS; DRUG TARGETING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS; STRESS; UNFOLDED PROTEIN RESPONSE;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; CATALYTIC DOMAIN; CELL LINE; CLONIDINE; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; GUANABENZ; HELA CELLS; HOMEOSTASIS; HUMANS; MOLECULAR CHAPERONES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; PROTEIN PHOSPHATASE 1; PROTEIN SUBUNITS; PROTEINS; STRESS, PHYSIOLOGICAL; TUNICAMYCIN;

EID: 79953288480     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1201396     Document Type: Article

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16. We thank A. Merritt and C. Wallace for biotinylated guanabenz, J. Hastie for purified recombinant PP1c, anonymous reviewers for suggestions, and M. Goedert for advice on the manuscript. Supported by the UK Medical Research Council. D.R. is a Wellcome Trust Principal Research Fellow. A.B. is a co-inventor on patent WO/2008/041133.