Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

Cancer Research

Volumn 65, Issue 24, 2005, Pages 11510-11519

  Nawrocki, Steffan T ^a   Carew, Jennifer S ^a   Dunner Jr , Kenneth ^a   Boise, Lawrence H ^b   Chiao, Paul J ^a   Huang, Peng ^a   Abbruzzese, James L ^a   McConkey, David J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CASPASE; CASPASE 3; CASPASE 4; CYCLOHEXIMIDE; CYTOCHROME C; DNA FRAGMENT; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; EUKARYOTE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BORONIC ACIDS; CALCIUM; CASPASES; CASPASES, INITIATOR; CYCLOHEXIMIDE; EIF-2 KINASE; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; OXIDATIVE STRESS; PANCREAS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRAZINES; RNA, SMALL INTERFERING; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP; UBIQUITIN;

EID: 29244470510     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2394     Document Type: Article

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