ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Genes and Development

Volumn 16, Issue 11, 2002, Pages 1345-1355

  Nishitoh, Hideki ^a   Matsuzawa, Atsushi ^a   Tobiume, Kei ^a   Saegusa, Kaoru ^a   Takeda, Kohsuke ^a   Inoue, Kiyoshi ^b   Hori, Seiji ^b,c   Kakizuka, Akira ^b,c,d   Ichijo, Hidenori ^a,d  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Apoptosis; ASK1; Endoplasmic reticulum stress; JNK; Polyglutamine disease; Ubiquitine proteasome system

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; GENE PRODUCT; POLYGLUTAMINE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN IRE1; STRESS ACTIVATED PROTEIN KINASE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; GENE ACTIVATION; GENETIC CODE; HUNTINGTON CHOREA; INHERITANCE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE REPEAT; PATHOGENICITY; PRIORITY JOURNAL; RAT; SPINOCEREBELLAR DEGENERATION; STRESS;

ANIMALS; APOPTOSIS; ARABIDOPSIS PROTEINS; CELL DEATH; CELL LINE; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HUMANS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; NEURONS; PC12 CELLS; PEPTIDES; PLANT PROTEINS; PLASMIDS; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THAPSIGARGIN; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0036606540     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.992302     Document Type: Article

References (47)

1. Impairment of the ubiquitin-proteasome system by protein aggregation
2. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
3. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance
4. E1F2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
5. Aggregation of hunting- tin in neuronal intranuclear inclusions and dystrophic neurites in brain
6. Activation of the cell death program by inhibition of proteasome function
7. Perk is essential for translational regulation and cell survival during the unfolded protein response
8. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
9. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation
10. VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
11. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
12. Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo
13. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
14. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
15. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
16. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
17. The ER translocon and retrotranslocation: Is the shift into reverse manual or automatic?
18. Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis
19. Protein precipitation: A common etiology in neurodegenerative disorders?
20. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
21. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
22. Genetic suppression of polyglutamine toxicity in Drosophila
23. Expanding our understanding of polyglutamine diseases through mouse models
24. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
25. Polyglutamine and CBP: Fatal attraction?
26. Caspase-12 mediates endoplasmic- reticulum-specific apoptosis and cytotoxicity by amyloid-β
27. ASK1 is essential for JNK/SAPK activation by TRAF2
28. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
29. Beyond the Qs in the polyglutamine diseases
30. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3
31. Polyglutamine disease and neuronal cell death
32. Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons
33. Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons
34. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
35. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
36. Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
37. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
38. Activation of ASK1 by the stress-induced activating phosphorylation of pre-formed oligomer
39. IRE1 and efferent signaling from the endoplasmic reticulum
40. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
41. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
42. Suppression of polyglutamine- mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
43. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
44. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
45. Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies
46. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
47. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase I and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38