The ERAD inhibitor eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Wang, Qiuyan ^a   Shinkre, Bidhan A ^a   Lee, Jin gu ^a   Weniger, Marc A ^b   Liu, Yanfen ^a   Chen, Weiping ^a   Wiestner, Adrian ^b   Trenkle, William C ^a   Ye, Yihong ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; BENZENE; EEYARESTATIN 1; NITROFURAN; PROTEIN P97; UNCLASSIFIED DRUG; 1 (4 CHLOROPHENYL) 3 (3 (4 CHLOROPHENYL) 5,5 DIMETHYL 1 (3 (5 NITROFURAN 2 YL)ALLYLDIENEHYDRAZINOCARBONYLMETHYL) 2 OXOIMIDAZOLIDIN 4 YL) 1 HYDROXYUREA; 1-(4-CHLOROPHENYL)-3-(3-(4-CHLOROPHENYL)-5,5-DIMETHYL-1-(3-(5-NITROFURAN-2-YL)ALLYLDIENEHYDRAZINOCARBONYLMETHYL)-2-OXOIMIDAZOLIDIN-4-YL)-1-HYDROXYUREA; DRUG DERIVATIVE; HYDRAZONE DERIVATIVE; HYDROXYUREA; NUCLEAR PROTEIN; P97 ATPASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; HELA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE BINDING; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN LOCALIZATION; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; TUMOR CELL; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTER ANALYSIS; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; INTRACELLULAR MEMBRANE; METABOLISM; PROTEIN BINDING; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATASES; CLUSTER ANALYSIS; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; HEK293 CELLS; HELA CELLS; HUMANS; HYDRAZONES; HYDROXYUREA; INTRACELLULAR MEMBRANES; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURFACE PLASMON RESONANCE;

EID: 78649742954     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015479     Document Type: Article

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