ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

Genes and Development

Volumn 22, Issue 11, 2008, Pages 1451-1464

  Nishitoh, Hideki ^a,b   Kadowaki, Hisae ^a,b,c,d   Nagai, Atsushi ^b   Maruyama, Takeshi ^b   Yokota, Takanori ^b   Fukutomi, Hisashi ^a,c,d   Noguchi, Takuya ^a,c,d   Matsuzawa, Atsushi ^a,c,d   Takeda, Kohsuke ^a,c,d   Ichijo, Hidenori ^a,c,d  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d Center of Excellence Program   (Japan)

Author keywords

Amyotrophic lateral sclerosis; ASK1; Derlin 1; Endoplasmic reticulum stress; Endoplasmic reticulum associated degradation

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; DERLIN 1 PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MUTANT PROTEIN; OLIGOPEPTIDE; PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; HUMAN; HUMAN CELL; LIFESPAN; MALE; MOTONEURON; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; CELL LINE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE KINASE KINASE 5; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

MUS MUSCULUS;

EID: 44849124411     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1640108     Document Type: Article

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