The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1492-1498

  Corrigall, V M ^a   Bodman Smith, M D ^a   Fife, M S ^a   Canas, B ^a   Myers, L K ^a   Wooley, P H ^a   Soh, C ^a   Staines, N A ^a   Pappin, D J C ^a   Berlo, S E ^a   Van Eden, W ^a   Van der Zee, R ^a   Lanchbury, J S ^a   Panayi, G S ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CHAPERONE; COLLAGEN TYPE 2; GLUCOSE REGULATED PROTEIN; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; PRISTANE;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HISTOPATHOLOGY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE; WESTERN BLOTTING;

EID: 0035253485     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1492     Document Type: Article

References (48)

1. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
2. T cell dependent pathways in rheumatoid arthritis
3. Abnormal distribution of the helper-inducer and suppressor-inducer T lymphocyte subsets in the rheumatoid joint
4. Lymphocyte involvement in rheumatoid arthritis: Studies during thoracic duct drainage
5. The use of cyclosporin A in rheumatoid arthritis: Proceedings of an international consensus meeting
6. Percentage of anti-CD4 monoclonal antibody coated lymphocytes in the rheumatoid joint is associated with clinical improvement: Implications for the development of immunotherapeutic dosing regimens
7. Evaluating candidate autoantigens in rheumatoid arthritis
8. Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in pristane induced arthritis susceptible and hsp 65 protected DBA/1 mice
9. Type II collagen-induced arthritis in mice. II. Passive transfer and suppression by intravenous injection of anti-type II collagen antibody or free native type II collagen
10. Early synovectomy in rheumatoid arthritis
11. Total condylar knee replacement in patients who have rheumatoid arthritis: A ten year follow-up study
12. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
13. Electrophoretic transfer of proteins from SDS and acid/urea gels to nitrocellulose
14. A rapid fluorescent staining procedure for proteins electroblotted onto PVDF membranes
15. Identification of myocardial proteins from two-dimensional gels by peptide-mass fingerprinting
16. Sample immobilisation protocols for matrix-assisted laser desorption mass spectrometry
17. Chemistry, mass spectrometry and peptide-mass databases: Evolution of methods for the rapid identification and mapping of cellular proteins
18. Rapid identification of proteins by peptide-mass fingerprinting
19. A novel N-terminal derivative designed to simplify peptide fragmentation
20. Protein sequencing by tandem mass spectrometry
21. Analytical properties of the nanoelectrospray ion source
22. Expression of the 65 kD heat shock protein in human chondrocytes
23. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
24. Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB3, DRB5 and DQB1 by PCR with 144 primer mixes utilising sequence-specific primers (PCR-SSP)
25. Type II collagen-induced arthritis in mice. III Suppression of arthritis by using monoclonal anti-Ia antisera
26. Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire
27. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates
28. Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen
29. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen
30. Autoimmunity to collagen: An experimental model of arthritis
31. A conserved mycobacterial heat shock protein (HSP) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-HSP70 homologue
32. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme
33. Oxygen free radicals, inflammation and synovitis: The current status
34. Hypoxia, oxidative stress and rheumatoid arthritis
35. Immunogenetics of animal models of arthritis
36. Complex regulation of heat shock- and glucose-responsive genes in human cells
37. Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart
38. Rat gene encoding the 78-kDa glucose-regulated protein GRP78: Its regulatory sequences and the effect of protein glycosylation on its expression
39. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins
40. Cytokines induce stress protein formation in cultured cardiac myocytes
41. Expression of stress proteins and lymphocyte reactivity in heterotopic cardiac allografts undergoing cellular rejection
42. Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins
43. Overexpression of human homologs of the bacterial DnaJ chaperone in the synovial tissue of patients with rheumatoid arthritis
44. Presence of human 65 kD heat shock protein (HSP) in inflamed joints and subcutaneous nodules of RA patients
45. Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis
46. Limiting-dilution analysis of T cell reactivity to mycobacterial antigens in peripheral blood and synovium from rheumatoid arthritis patients
47. Limiting dilution analysis of proliferative T cell responses to mycobacterial 65-kDa heat-shock protein fails to show significant frequency differences between synovial fluid and peripheral blood of patients with rheumatoid arthritis
48. Enhanced expression of heat shock protein 70 (HSP70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue: Differential regulation of HSP70 expression and HSF1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress and antiinflammatory drugs