GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

Journal of Clinical Investigation

Volumn 119, Issue 5, 2009, Pages 1201-1215

  Kammoun, Hélène L ^a,b   Chabanon, Hervé ^a,b   Hainault, Isabelle ^a,b   Luquet, Serge ^c   Magnan, Christophe ^c   Koike, Tatsuro ^d   Ferré, Pascal ^a,b   Foufelle, Fabienne ^a,b  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CNRS   (France)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CHOLESTEROL; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; INSULIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN, MOUSE; CHAPERONE; HEAT SHOCK PROTEIN; INSULIN RECEPTOR SUBSTRATE; MOLECULAR CHAPERONE GRP78; NUCLEAR PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THAPSIGARGIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; FOOD INTAKE; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER; LIVER CELL CULTURE; LIVER WEIGHT; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENETICS; LIVER CELL; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT; ZUCKER RAT;

ANIMALS; ENDOPLASMIC RETICULUM; FATTY LIVER; GENE EXPRESSION; GLUCOSE; HEAT-SHOCK PROTEINS; HEPATOCYTES; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MALE; MICE; MICE, OBESE; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; NUCLEAR PROTEINS; OBESITY; RATS; RATS, WISTAR; RATS, ZUCKER; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THAPSIGARGIN; TRANSCRIPTION FACTORS;

EID: 66449137379     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37007     Document Type: Article

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