Retraction: Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α (Sience (2006) 312 (572) DOI: 10.1126/science.1123480);Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α

Science

Volumn 312, Issue 5773, 2006, Pages 572-576

  Hetz, Claudio ^a,b   Bernasconi, Paula ^a   Fisher, Jill ^a   Lee, Ann Hwee ^b   Bassik, Michael C ^a   Antonsson, Bruno ^c   Brandt, Gabriel S ^d   Iwakoshi, Neal N ^b   Schrinzel, Anna ^a   Glimcher, Laurie H ^a,b   Korsmeyer, Stanley J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

^d BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYMES; TISSUE;

ENDOPLASMIC RETICULUM (ER); PROAPOPTOTIC BAX; TRANSMEMBRANE PROTEIN KINASE;

PROTEINS;

INOSITOL REQUIRING TRANSMEMBRANE KINASE AND ENDONUCLEASE 1ALPHA; MEMBRANE PROTEIN; PROTEIN BAK; PROTEIN BAX; TUNICAMYCIN; UNCLASSIFIED DRUG;

CYTOLOGY; GENE; GENETICS; MEMBRANE; PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 33646237823     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.adp1104     Document Type: Erratum

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34. We thank N. Danial, K. Hurov, G. Wei, S. Lin, S. Oakes, F. Urano, and K. Lipson for helpful discussions of the manuscript and C. Gee, L. Shehu, and J. Tomeu for project management assistance. We also thank E. Smith for graphic design and M. Nishimo, P. Thielen, J. Quijada, and M. Godes for technical assistance. We are grateful to D. Ron for providing IRE1α knockout MEFs and PERK expression vectors, F. Urano for providing anti-IRE1α antibodies, M. Tagaya for the cytochrome b5 expression vector, and C. Thompson for the 8AK-cytochrome b5 mutant expression vector. We thank J. Patterson for providing us siRNA vectors to target BiP mRNA. This work was supported by NIH grants P01 CA92625 and R37 CA50239 (S.J.K.); P01 AI56296, and R01 AI32412 and by an Ellison Medical Foundation grant (L.H.G.); and by postdoctoral fellowships from the Damon Runyon Cancer Research Foundation (C.H.), the Irvington Institute for Immunological Research (N.N.I.), and a Career Development Award CA100707 (A.H.L.). We dedicate this article to Stanley J. Korsmeyer, whose untimely death from cancer was a great loss for us all.