The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis

Free Radical Research

Volumn 44, Issue 9, 2010, Pages 1082-1090

  Shimazaki, Hiroko ^a   Watanabe, Kenichi ^a   Veeraveedu, Punniyakoti T ^a   Harima, Meilei ^a   Thandavarayan, Rajarajan A ^a   Arozal, Wawaimuli ^a   Tachikawa, Hitoshi ^b   Kodama, Makoto ^b   Aizawa, Yoshifusa ^b  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

apoptosis; Edaravone; endoplasmic reticulum stress; experimental autoimmune myocarditis; oxidative stress

Indexed keywords

CARDIAC MYOSIN; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE P38; NORPHENAZONE; PROTEIN P47 PHOX; PROTEIN P67 PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE MYOCARDITIS; BODY WEIGHT; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DOWN REGULATION; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM STRESS; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART WEIGHT; MALE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; ANTIPYRINE; APOPTOSIS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM; HEART; MALE; MYOCARDITIS; MYOCARDIUM; RATS; RATS, INBRED LEW; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE; VENTRICULAR DYSFUNCTION, LEFT;

RATTUS; SUS;

EID: 77956383408     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2010.499904     Document Type: Article

References (43)

1. Feldman AM, McNamara D. Myocarditis. N Engl J Med 2000;343:1388-1398.
2. Kodama M, Matsumoto Y, Fujiwara M, Zhang SS, Hanawa H, Itoh E, Tsuda T, Izumi T, Shibata A. Characteristics of giant cells and factors related to the formation of giant cells in myocarditis. Circ Res 1991;69:1042-1050.
3. Kodama M, Hanawa H, Saeki M, Hosono H, Inomata T, Suzuki K, Shibata A. Rat dilated cardiomyopathy after autoimmune giant cell myocarditis. Circ Res 1994;75:278-284.
4. Watanabe K, Kodama M, Aizawa Y. Immune-mediated myocarditis and inter leukin-10. In: Giora Z, Feuerstein PL, Mann DL, editors. Inflammation and Cardiac Diseases Basel: Birkh ä usre Verlag; 2003. p 189-202.
5. Frey RS, Ushio-Fukai M, Malik AB. NADPH oxidase-de-rived reactive oxygen species in the regulation of endothelial phenotype. Antioxid Redox Signal 2008;60:21-28.
6. Kannan K, Jain SK. Oxidative stress and apoptosis. Patho-physiology 2000;7:153-163.
7. Younce CW, Kolattukudy PE. MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxida-tive stress generated by inducing a novel Zn-finger protein, MCPIP. Biochem J 2010;43:43-53.
8. Santos CX, Tanaka LY, Wosniak J, Laurindo FR. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: role of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 2009;11:2409-2427.
9. Oyadomari S, Mori M. Roles of CHOP/GADD153 in endo-plasmic reticulum stress. Cell Death Differ 2004;11:381-389.
10. Watanabe T, Tanaka M, Watanabe K, Takamatsu Y, Tobe A. Research and development of the free radical scavenger edar-avone as a neuroprotectant. Yakugaku Zasshi 2004;124: 99-111.
11. Higashi Y, Jitsuiki D, Chayama K, Yoshizumi M. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Pat Cardiovasc Drug Discov 2006;1:85-93.
12. Nishi H, Watanabe T, Sakurai H, Yuki S, Ishibashi A. Effect of MCI-186 on brain edema in rats. Stroke 1989;20:1236-1240.
13. Oishi R, Itoh Y, Nishibori M, Watanabe T, Nishi H, Saeki K. Effect of MCI-186 on ischemia-induced changes in monoam-ine metabolism in rat brain. Stroke 1989;20:1557-1564.
14. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994;268:1597-1604.
15. Watanabe T, Egawa M. Effect of an antistoroke agent MCI-186 on cerebral arachidonate cascade. J Pharmacol Exp Ther 1994;271:1624-1629.
16. Nakamura H, Uzura M, Uchida K, Nakayama H, Furuya Y, Hayashi T, Sekino H, Ominato M, Owada S. Effects of edar-avone on experimental brain injury in view of free radical reaction. Acta Neurochir Suppl 2003;86:309-311.
17. Tsujita K, Shimomura H, Kawano H, Hokamaki J, Fukuda M, Yamashita T, Hida S, Nakamura Y, Nagayoshi Y, Sakamoto T, Yoshimura M, Arai H, Ogawa H. Effects of edaravone on reperfusion injury in patients with acute myocardial infarction. Am J Cardiol 2004;94:481-484.
18. Fukudome D, Matsuda M, Kawasaki T, Ago Y, Matsuda T. The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice. Eur J pharmacol 2008;583:164-169.
19. Ikegami E, Fukazawa R, Kanbe M, Watanabe M, Abe M, Watanabe M, Kamisago M, Hajikano M, Katsube Y, Ogawa S. Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death. Circ J 2007;71: 1815-1820.
20. Qi X, Okuma Y, Hosoi T, Nomura Y. Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction. J Pharmacol Exp Ther 2004;311:388-393.
21. Watanabe K, Ohta Y, Nakazawa M, Higuchi H, Hasegawa G, Naito M, Fuse K, Ito M, Hirono S, Tanabe N, Hanawa H, Kato K, Kodama M, Aizawa Y. Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopa-thy. Br J Pharmacol 2000;130:1489-1495.
22. Tanaka H, Watanabe K, Harima M, Thanikachalam PV, Yamaguchi K, Tachikawa H, Kodama M, Aizawa Y. Effects of various diuretics on cardiac function in rats with heart failure. Yakugaku Zasshi 2009;129:871-879.
23. Tsutsui H, Kinugawa S, Matsushita S. Oxidative stress and mitochondrial DNA damage. Circ J 2008;72(suppl A): 31-37.
24. Dhalla NS, Temsah RM, Netti Cadan T. Role of oxidative stress in cardiovascular diseases. J Hypertens 2000;18: 655-673.
25. Tsujimoto I, Hikoso S, Yamaguchi O, Kashiwase K, Nakai A, Takeda T, Watanabe T, Taniike M, Matsumura Y, Nishida K, Hori M, Kogo M, Otsu K. The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Hypertension 2005;45:921-926.
26. Hewitson TD, Darby IA. In situ localization of apoptosis using TUNEL. Methods Mol Biol 2010;611:161-170.
27. Amemiya S, Kamiya T, Nito C, Inaba T, Kato K, Ueda M, Shimazaki K, Katayama Y. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol 2005;516:125-130.
28. Nimata M, Okabe T, Hattori M, Yuan Z, Shioji K, Kishimoto C. MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats. Am J Physiol Heart Circ Physiol 2005;289:2514-2518.
29. Okabe T, Kishimoto C, Hattori M, Nimata M, Shioji K, Kita T. Cardioprotective effects of 3-methyl-1-phenyl-2-pyra-zolin-5-one (MCI-186), a novel free radical scavenger, on acute autoimmune myocarditis is rats. Exp Clin Cardiol 2004; 9:177-180.
30. Yuan Z, Shioji Y, Kihara Y, Takenaka H, Onozawa Y, Kishi-moto C. Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property. Am J Physiol Heart Circ Physiol 2004;286:83-90.
31. Einaga H, Yoshihara E, Matsuo Y, Yodoi J. Oxidative stress and redox regulation-protein oxidative modification and activation. Seibutsu Shiryo Bunseki 2009;32:265-272.
32. Haliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and signifi cance. Am J Clin Nutr 1993;57: 715-725.
33. Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC. The rac effector p67phox regulates phagocyte NADPH oxidase by stimulating vav1 guanine nucleotide exchange activity. Mol Cell Biol 2007;27:312-323.
34. Kyaw M, Yoshizumi M, Tsuchiya K, Izawa Y, Kanematsu Y, Tamaki T. Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinase. Acta Pharmacol Sin 2004;25:977-985.
35. Minamino T, Kitakaze M. ER stress in cardiovascular disease. J Mol Cell 2010;48:1105-1110.
36. Liu H, Li W, Gu W, Kong Y, Yang N, Chen L. Immunoregula-tory effects of carvedilol on rats experimental autoimmune myocarditis. Scand J Immunol 2010;71:38-44.
37. Yang T, Mao YF, Liu SQ, Hou J, Cai ZY, Ni X, Deng XM, Zhu X Y. Protective effects of the free radical scavenger edar-avone on acute pancreatitis- associated lung injury. Eur J Pharmacol 2010;630:152-157.
38. Prins D, Michalak M. Endoplasmic reticulum proteins in cardiac development and dysfunction. Can J Physiol Pharmacol 2009;87:419-425.
39. Lai E, Teodoro T, Volchuk A. Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology 2007;22: 193-201.
40. Ueda S, Matsutani H, Nakamura H, Tanaka T, Ueno M, Yodoi J. Redoxcontrol of cell death. Antioxid Redox Signal 2002; 4:405-414.
41. Okada K, Minamino T, Kitakaze M. Role of endoplasmic reticulum stress in cardiac development and dysfunction. Folia Pharmacolo Jpn 2005;126:385-389.
42. Haga T, Suzuki J, Kosuge H, Ogawa M, Saiki H, Haraguchi G, Maejima Y, Isobe M, Ueda T. Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. J Mol Cell Cardiol 2009;46: 719-727.
43. Wen J, Watanabe K, Ma M, Yamaguchi K, Tachikawa H, Kodama M, Aizawa Y. Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats. Biol Pharm Bull 2006;29:713-718.