ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

Cell

Volumn 129, Issue 7, 2007, Pages 1337-1349

  Puthalakath, Hamsa ^a   O'Reilly, Lorraine A ^a   Gunn, Priscilla ^a   Lee, Lily ^a   Kelly, Priscilla N ^a,b   Huntington, Nicholas D ^a   Hughes, Peter D ^a,b   Michalak, Ewa M ^a   McKimm Breschkin, Jennifer ^c   Motoyama, Noburo ^d   Gotoh, Tomomi ^e   Akira, Shizuo ^f   Bouillet, Philippe ^a   Strasser, Andreas ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c CSIRO   (Australia)

^d NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

^f OSAKA UNIVERSITY   (Japan)

Author keywords

CELLBIO; SIGNALING

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; BINDING PROTEIN; CYTOKINE; CYTOTOXIC AGENT; ENHANCER BINDING PROTEIN ALPHA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL KILLING; CELL TYPE; DEGENERATIVE DISEASE; EMBRYO; ENDOPLASMIC RETICULUM STRESS; ENZYME DEGRADATION; INTERVENTION STUDY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN INDUCTION; PROTEIN MALNUTRITION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STIMULUS; UBIQUITINATION;

ANIMALIA;

EID: 34250758642     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2007.04.027     Document Type: Article

References (35)

1. Becker E.B.E., and Bonni A. Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery. Neuron 49 (2006) 655-662
2. Bouillet P., Metcalf D., Huang D.C.S., Tarlinton D.M., Kay T.W.H., Köntgen F., Adams J.M., and Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286 (1999) 1735-1738
3. Bouillet P., Purton J.F., Godfrey D.I., Zhang L.-C., Coultas L., Puthalakath H., Pellegrini M., Cory S., Adams J.M., and Strasser A. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415 (2002) 922-926
4. Bouillet P., Robati M., Bath M.L., and Strasser A. Polycystic kidney disease prevented by transgenic RNA interference. Cell Death Differ. 12 (2005) 831-833
5. Bouillet P., Zhang L.C., Huang D.C., Webb G.C., Bottema C.D., Shore P., Eyre H.J., Sutherland G.R., and Adams J.M. Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mamm. Genome 12 (2001) 163-168
6. Dijkers P.F., Medema R.H., Lammers J.J., Koenderman L., and Coffer P.J. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10 (2000) 1201-1204
7. Enders A., Bouillet P., Puthalakath H., Xu Y., Tarlinton D.M., and Strasser A. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreative B cells. J. Exp. Med. 198 (2003) 1119-1126
8. Etlinger J.D., and Goldberg A.L. A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. Proc. Natl. Acad. Sci. USA 74 (1977) 54-58
9. Favre B., Turowski P., and Hemmings B.A. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J. Biol. Chem. 272 (1997) 13856-13863
10. Hildeman D.A., Zhu Y., Mitchell T.C., Bouillet P., Strasser A., Kappler J., and Marrack P. Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member, Bim. Immunity 16 (2002) 759-767
11. Hitomi J., Katayama T., Eguchi Y., Kudo T., Taniguchi M., Koyama Y., Manabe T., Yamagishi S., Bando Y., Imaizumi K., et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J. Cell Biol. 165 (2004) 347-356
12. Huang D.C.S., and Strasser A. BH3-only proteins - essential initiators of apoptotic cell death. Cell 103 (2000) 839-842
13. Jeffers J.R., Parganas E., Lee Y., Yang C., Wang J., Brennan J., MacLean K.H., Han J., Chittenden T., Ihle J.N., et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4 (2003) 321-328
14. Kaufman R.J. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110 (2002) 1389-1398
15. Kong M., Fox C.J., Mu J., Solt L., Xu A., Cinalli R.M., Birnbaum M.J., Lindsten T., and Thompson C.B. The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 306 (2004) 695-698
16. Lewis R.S. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19 (2001) 497-521
17. Ley R., Ewings K.E., Hadfield K., and Cook S.J. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ. 12 (2005) 1008-1014
18. Li J., Lee B., and Lee A.S. Endoplasmic reticulum-stress induced apoptosis: Multiple pathways and activation of p53-up-regulated modulation of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281 (2006) 7260-7270
19. Marciniak S.J., Yun C.Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R., Nagata K., Harding H.P., and Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18 (2004) 3066-3077
20. McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., and Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21 (2001) 1249-1259
21. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., and Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 403 (2000) 98-103
22. Okada T., Haze K., Nadanaka S., Yoshida H., Seidah N.G., Hirano Y., Sato R., Negishi M., and Mori K. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J. Biol. Chem. 278 (2003) 31024-31032
23. Puthalakath H., Huang D.C.S., O'Reilly L.A., King S.M., and Strasser A. The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell 3 (1999) 287-296
24. Puthalakath H., and Strasser A. Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 9 (2002) 505-512
25. Puthalakath H., Villunger A., O'Reilly L.A., Beaumont J.G., Coultas L., Cheney R.E., Huang D.C.S., and Strasser A. Bmf: a pro-apoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293 (2001) 1829-1832
26. Reimertz C., Kogel D., Rami A., Chittenden T., and Prehn J.H. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J. Cell Biol. 162 (2003) 587-597
27. Ron D. Translational control in the endoplasmic reticulum stress response. J. Clin. Invest. 110 (2002) 1383-1388
28. Rutishauser J., and Spiess M. Endoplasmic reticulum storage diseases. Swiss Med. Wkly. 132 (2002) 211-222
29. Saleh M., Mathison J.C., Wolinski M.K., Bensinger S.J., Fitzgerald P., Droin N., Ulevitch R.J., Green D.R., and Nicholson D.W. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440 (2006) 1064-1068
30. Schneider C., Newman R.A., Sutherland D.R., Asser U., and Greaves M.F. A one-step purification of membrane proteins using a high efficiency immunomatrix. J. Biol. Chem. 257 (1982) 10766-10769
31. Tsutsumi S., Gotoh T., Tomisato W., Mima S., Hoshino T., Hwang H.J., Takenaka H., Tsuchiya T., Mori M., and Mizushima T. Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis. Cell Death Differ. 11 (2004) 1009-1016
32. Villunger A., Michalak E.M., Coultas L., Müllauer F., Böck G., Ausserlechner M.J., Adams J.M., and Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa. Science 302 (2003) 1036-1038
33. Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2 (2002) 594-604
34. Wang H.-G., Pathan N., Ethell I.M., Krajewski S., Yamaguchi Y., Shibasaki F., McKeon F., Bobo T., Franke T.F., and Reed J.C. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284 (1999) 339-343
35. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., and Korsmeyer S.J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292 (2001) 727-730