Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

Science

Volumn 306, Issue 5695, 2004, Pages 457-461

  Özcan, Umut ^a   Cao, Qiong ^a   Yilmaz, Erkan ^a   Lee, Ann Hwee ^a   Iwakoshi, Neal N ^a   Özdelen, Esra ^a   Tuncman, Gürol ^a   Görgün, Cem ^a   Glimcher, Laurie H ^a,b   Hotamisligil, Gökhan S ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DISEASE CONTROL; ENZYMES; INSULIN; PROTEINS; SIGNAL PROCESSING; SUBSTRATES;

ENDOPLASMIC RETICULUM STRESS; HYPERACTIVATION; INSULIN RECEPTOR; OBESITY;

DISEASES;

BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; SERINE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

MEDICINE;

ARTICLE; CELL CULTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DNA-BINDING PROTEINS; EIF-2 KINASE; ENDOPLASMIC RETICULUM; GLUCOSE; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; LIVER; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, OBESE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SKELETAL; MUTATION; NUCLEAR PROTEINS; OBESITY; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUNICAMYCIN;

EID: 5644231992     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103160     Document Type: Article

References (27)

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27. We thank the Hotamisligil laboratory for their contributions and J. Gound and L. Beppu for technical assistance. Supported in part by NIH grants AI32412 (L.H.G.), DKS2S39 (G.S.H.), American Diabetes Association (G.S.H.), PO5-CA100707 (L.H.G., A.H.L.), an Irvington Institute Postdoctoral Fellowship Award (N.I.), an NIH training grant T32-DK07703 (Q.C.), and a postdoctoral fellowship from the laccoca Foundation (G.T.). L.H.G. holds equity in MannKind Corporation, which has licensed the XBP-1 technology.