XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

EMBO Journal

Volumn 28, Issue 11, 2009, Pages 1624-1636

  Hu, Chih Chi Andrew ^a   Dougan, Stephanie K ^a   McGehee, Annette M ^a   Love, J Christopher ^a   Ploegh, Hidde L ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

BCR signalling; Blimp 1; Chemokine receptors; CXCl12; IRF4

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; B LYMPHOCYTE RECEPTOR; CD79A ANTIGEN; CD79B ANTIGEN; INTERFERON REGULATORY FACTOR 4; STROMAL CELL DERIVED FACTOR 1; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CONTROLLED STUDY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; BONE MARROW; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; MICE; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MUS MUSCULUS;

EID: 67349176043     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.117     Document Type: Article

References (38)

1. Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, lents NH, Arias C, lennon CJ, Kluger Y, Dynlacht BD (2007) XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell 27: 53-66
2. Boes M, Esau C, Fischer MB, Schmidt T, Carroll M, Chen J (1998) Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol 160: 4776-4787
3. Bordier C (1981) Phase separation of integral membrane proteins in Triton X-114 solution. J Biol Chem 256: 1604-1607
4. Brunsing R, Omori-Fitzpatrick S, Weber F, Bicknell AA, Friend l, Rickert R, Niwa M (2008) B and Tcell development both involve activity of the unfolded protein response pathway. J Biol Chem 283: 17954-17961
5. Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96
6. Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, Tonon G, DePinho RA (2007) The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11 : 349-360
7. Dykstra M, Cherukuri A, Sohn HW, Tzeng SJ, Pierce SK (2003) location is everything: lipid rafts and immune cell signaling. Annu Rev Immunol 21: 457-481
8. Gass JN, Gifford NM, Brewer JW (2002) Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J Biol Chem 277: 49047-49054
9. Goodnow CC, Crosbie J, Adelstein S, lavoie TB, Smith-Gill SJ, Brink RA, Pritchard-Briscoe H, Wotherspoon JS, loblay RH, Raphael K, Trent RJ, Basten A (1988) Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682
10. Hetz C, lee AH, Gonzalez-Romero D, Thielen P, Castilla J, Soto C, Glimcher lH (2008) Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci USA 105: 757-762
11. Iwakoshi NN, lee AH, Glimcher lH (2003a) The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev 194: 29-38
12. Iwakoshi NN, lee AH, Vallabhajosyula P, Otipoby Kl, Rajewsky K, Glimcher lH (2003b) Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 4: 321-329
13. Kallies A, Hasbold J, Fairfax K, Pridans C, Emslie D, McKenzie BS, lew AM, Corcoran lM, Hodgkin PD, Tarlinton DM, Nutt Sl (2007) Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity 26: 555-566
14. Kallies A, Hasbold J, Tarlinton DM, Dietrich W, Corcoran lM, Hodgkin PD, Nutt Sl (2004) Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med 200: 967-977
15. Kaser A, lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher lH, Blumberg RS (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134: 743-756
16. Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh Hl (2006) Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proc Natl Acad Sci USA 103: 3327-3332
17. Klein U, Casola S, Cattoretti G, Shen Q, lia M, Mo T, ludwig T, Rajewsky K, Dalla-Favera R (2006) Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol 7: 773-782
18. Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh Hl (2007) AID - / - mus - / - mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells. J Immunol 178: 2192-2203
19. lee AH, Chu GC, Iwakoshi NN, Glimcher lH (2005) XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 24: 4368-4380
20. lee AH, Iwakoshi NN, Glimcher lH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23: 7448-7459
21. lee AH, Scapa EF, Cohen DE, Glimcher lH (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496
22. Martins G, Calame K (2008) Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol 26: 133-169
23. Matloubian M, lo CG, Cinamon G, lesneski MJ, Xu Y, Brinkmann V, Allende Ml, Proia Rl, Cyster JG (2004) lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360
24. Muehlinghaus G, Cigliano l, Huehn S, Peddinghaus A, leyendeckers H, Hauser AE, Hiepe F, Radbruch A, Arce S, Manz RA (2005) Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood 105: 3965-3971
25. Pierce SK (2002) lipid rafts and B-cell activation. Nat Rev Immunol 2: 96-105
26. Pillai S, Cariappa A, Moran ST (2004) Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunol Rev 197: 206-218
27. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher lH (2001) Plasma cell differentiation requires the transcription factor XBP-1. Nature 412: 300-307
28. Rosen H, Goetzl EJ (2005) Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 5: 560-570
29. Schwab SR, Cyster JG (2007) Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 8: 1295-1301
30. Sciammas R, Shaffer Al, Schatz JH, Zhao H, Staudt lM, Singh H (2006) Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25: 225-236
31. Shaffer Al, lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A, Giltnane JM, Yang l, Zhao H, Calame K, Staudt lM (2002) Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17: 51-62
32. Shen X, Ellis RE, lee K, liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107: 893-903
33. Sriburi R, Bommiasamy H, Buldak Gl, Robbins GR, Frank M, Jackowski S, Brewer JW (2007) Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem 282: 7024-7034
34. Sriburi R, Jackowski S, Mori K, Brewer JW (2004) XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol 167: 35-41
35. Tirosh B, Iwakoshi NN, Glimcher lH, Ploegh Hl (2005) XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. J Exp Med 202: 505-516
36. van Anken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R, Braakman I, Heck AJ (2003) Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 18: 243-253
37. Vieira P, Rajewsky K (1988) The half-lives of serum immunoglobulins in adult mice. Eur J Immunol 18: 313-316
38. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891