ER stress controls iron metabolism through induction of hepcidin

Science

Volumn 325, Issue 5942, 2009, Pages 877-880

  Vecchi, Chiara ^a   Montosi, Giuliana ^a   Zhang, Kezhong ^b   Lamberti, Igor ^a   Duncan, Stephen A ^c   Kaufman, Randal J ^d   Pietrangelo, Antonello ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREBH PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HEPCIDIN; TOXIN; UNCLASSIFIED DRUG;

ANEMIA; CELL ORGANELLE; HOMEOSTASIS; HORMONE; IMMUNITY; IRON; METABOLISM; PEPTIDE; PROTEIN; RODENT; SECRETION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; INNATE IMMUNITY; IRON DEFICIENCY ANEMIA; IRON METABOLISM; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN QUALITY; TRANSACTIVATION;

3T3 CELLS; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENDOPLASMIC RETICULUM; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; IRON; LIVER; MICE; MICE, KNOCKOUT; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN FOLDING; RNA INTERFERENCE; SPLEEN; STRESS, PHYSIOLOGICAL; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 68949220321     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1176639     Document Type: Article

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23. We thank V. Salsi for assistance with ChIP analyses and V. Zappavigna and D. H. Perlmutter for helpful suggestions. Supported by European Union grant EUROIRON Ct.2006- 037296 (A.P.) and NIH grants DK42394, HL52173, and PO1 HL057346 (R.J.K.). R.J.K. is an Investigator of the Howard Hughes Medical Institute.