Mechanisms of hepatotoxicity

Toxicological Sciences

Volumn 65, Issue 2, 2002, Pages 166-176

  Jaeschke, Hartmut ^a   Gores, Gregory J ^b   Cederbaum, Arthur I ^c   Hinson, Jack A ^a   Pessayre, Dominique ^d   Lemasters, John J ^e  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b MAYO CLINIC   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d BEAUJON HOSPITAL   (France)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Bile acids; Cholestasis; Cytochrome P4502E1; Kupffer cells; Microvesicular steatosis; Mitochondrial permeability transition; Neutrophils; Nitric oxide; Oxidative stress; Peroxynitrite

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; ALLYL ALCOHOL; ALPHA INTERFERON; BETULIC ACID; BILE ACID; BROMOBENZENE; CASPASE; CHEMOKINE; CHLOROFORM; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOKINE; FAS LIGAND; FIALURIDINE; GLUCOCORTICOID; IBUPROFEN; MITOCHONDRIAL DNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEOSIDE ANALOG; PARACETAMOL; REACTIVE OXYGEN METABOLITE; SALICYLIC ACID; SUPEROXIDE; TETRACYCLINE DERIVATIVE; UNINDEXED DRUG; VALPROIC ACID; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL MEMBRANE; CHOLESTASIS; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; DRUG WITHDRAWAL; ENZYME SUBSTRATE; FATTY ACID OXIDATION; HEPATITIS; HUMAN; KNOCKOUT MOUSE; KUPFFER CELL; LEUKOCYTE ACTIVATION; LIPID PEROXIDATION; LIVER CELL; LIVER TOXICITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NEUTROPHIL CHEMOTAXIS; NITRATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEATOSIS; TARGET ORGAN;

ANIMALS; CELLS, CULTURED; CHOLESTASIS; HEPATITIS, TOXIC; HEPATOCYTES; HUMANS; KUPFFER CELLS; LIVER; MITOCHONDRIA, LIVER; MITOCHONDRIAL DISEASES; OXIDATIVE STRESS; XENOBIOTICS;

ANIMALIA;

EID: 0036163759     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/65.2.166     Document Type: Article

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