IRE1 signaling affects cell fate during the unfolded protein response

Science

Volumn 318, Issue 5852, 2007, Pages 944-949

  Lin, Jonathan H ^a   Li, Han ^a   Yasumura, Douglas ^a   Cohen, Hannah R ^a   Zhang, Chao ^a,b   Panning, Barbara ^a   Shokat, Kevan M ^a,b   LaVail, Matthew M ^a   Walter, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN IRE1;

APOPTOSIS; CELL ORGANELLE; ECOLOGICAL MODELING; GENE EXPRESSION; MOLECULAR ANALYSIS; MUTATION; PIGMENT; PROTEIN;

ARTICLE; CELL DEATH; CELL FATE; CELL PROTECTION; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HUMANS; KINETICS; MEMBRANE PROTEINS; MICE; MUTATION; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RATS; RETINA; RETINITIS PIGMENTOSA; RHODOPSIN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 36049049392     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1146361     Document Type: Article

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29. We thank the Walter lab, B. Farese, J. L. Garrison, R. J. Kaufman, R. Locksley, M. Matthes, D. Morgan, J. Nathans, R. Prywes, F. Sanchez, and B. Yen for comments, provision of reagents, or technical advice. This work was supported by the Amyotrophic Lateral Sclerosis Association, U.S. Department of Defense, Foundation Fighting Blindness, John Douglas French Alzheimer's Foundation, National Eye Institute, NIH, and Research to Prevent Blindness. P.W. and K.M.S. are Howard Hughes Medical Institute Investigators.