Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

Nature

Volumn 429, Issue 6987, 2004, Pages 75-79

  Saleh, Maya ^a   Vaillancourt, John P ^a   Graham, Rona K ^b   Huyck, Matthew ^c   Srinivasula, Srinivasa M ^d   Alnemri, Emad S ^d   Steinberg, Martin H ^c   Holan, Vikki ^c   Baldwin, Clinton T ^c   Hotchkiss, Richard S ^e   Buchman, Timothy G ^e   Zehnbauer, Barbara A ^e   Hayden, Michael R ^b   Farrer, Lindsay A ^c   Roy, Sophie ^a   Nicholson, Donald W ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; ENZYME KINETICS; GROWTH KINETICS; IMMUNOLOGY; PROTEINS;

APOPTOTIC SENSITIVITY; CELL DEATH; CELLULAR APOPTOSIS; POLYMORPHISM;

NATURAL SCIENCES;

AMYLOID BETA PROTEIN; CASPASE 12; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; GENOMIC DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 8; RNA; TUMOR NECROSIS FACTOR ALPHA; CASP12P1 PROTEIN, HUMAN; CASPASE; CONCANAVALIN A; LIPOPOLYSACCHARIDE;

MEDICINE;

AFRICAN AMERICAN; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMAN; IMMUNE SYSTEM; INFLAMMATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SEPTIC SHOCK; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING; AFRICA; ANIMAL; BLOOD; CASE CONTROL STUDY; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENDOPLASMIC RETICULUM; ETHNOLOGY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; METABOLISM; NUCLEOTIDE SEQUENCE; PRIMATE; SEPSIS;

ESCHERICHIA COLI;

AFRICA; AFRICAN AMERICANS; ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CASE-CONTROL STUDIES; CASPASE 12; CASPASES; CONCANAVALIN A; CYTOKINES; ENDOPLASMIC RETICULUM; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; NF-KAPPA B; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIMATES; SEPSIS;

EID: 2342457148     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02451     Document Type: Article

References (18)

1. Nicholson, D. W. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6, 1028-1042 (1999).
2. Lamkanfi, M., Declercq, W., Kalai, M., Saelens, X. & Vandenabeele, P. Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ. 9, 358-361 (2002).
3. Nakagawa, T. et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 403, 98-103 (2000).
4. Fischer, H., Koenig, U., Eckhart, L. & Tschachler, E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293, 722-726 (2002).
5. Chan, S. L., Culmsee, C., Haughey, N., Klapper, W. & Mattson, M. P. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol. Dis. 11, 2-19 (2002).
6. Kouroku, Y. et al. Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum. Mol. Genet. 11, 1505-1515 (2002).
7. Shibata, M. et al. Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice. Neuroscience 118, 491-499 (2003).
8. Mouw, G. et al. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat NeuroReport 14, 183-186 (2003).
9. Stehlik, C. et al. The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-κB and pro-caspase-1 regulation. Biochem. J. 373, 101-113 (2003).
10. Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426 (2002).
11. Srinivasula, S. M. et al. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277, 21119-21122 (2002).
12. Grenier, J. M. et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1. FEBS Lett. 530, 73-78 (2002).
13. Bouchier-Hayes, L. & Martin, S. J. CARD games in apoptosis and immunity. EMBO Rep. 3, 616-621 (2002).
14. Hotchkiss, R. S. et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nature Immunol. 1, 496-501 (2000).
15. + T lymphocytes in humans. J. Immunol. 166, 6952-6963 (2001).
16. Green, R. C. et al. Risk of dementia among white and African American relatives of patients with Alzheimer disease. J. Am. Med. Assoc. 287, 329-336 (2002).
17. McKhann, G. et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939-944 (1984).
18. Freeman, B. D., Buchman, T. G., McGrath, S., Tabrizi, A. R. & Zehnbauer, B. A. Template-directed dye-terminator incorporation with fluorescence polarization detection for analysis of single nucleotide polymorphisms implicated in sepsis. J. Mol. Diagn. 4, 209-215 (2002).