Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

Nature Chemical Biology

Volumn 3, Issue 6, 2007, Pages 331-338

  Sarkar, Sovan ^a   Perlstein, Ethan O ^b,c   Imarisio, Sara ^d   Pineau, Sandra ^a   Cordenier, Axelle ^d   Maglathlin, Rebecca L ^c   Webster, John A ^c   Lewis, Timothy A ^c   O'Kane, Cahir J ^d   Schreiber, Stuart L ^c,e   Rubinsztein, David C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b HARVARD UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BAFILOMYCIN A1; CENTRAL NERVOUS SYSTEM AGENTS; HUNTINGTIN; MUTANT PROTEIN; RAPAMYCIN; SMALL MOLECULE ENHANCER OF RAPAMYCIN 10; SMALL MOLECULE ENHANCER OF RAPAMYCIN 18; SMALL MOLECULE ENHANCER OF RAPAMYCIN 28; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG EFFECT; DRUG MECHANISM; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MAMMAL CELL; MONOTHERAPY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

DROSOPHILA MELANOGASTER; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 34248994604     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio883     Document Type: Article

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