Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model

Free Radical Biology and Medicine

Volumn 51, Issue 3, 2011, Pages 671-680

  Wu, Cheng Tien ^a   Sheu, Meei Ling ^b   Tsai, Keh Sung ^a   Chiang, Chih Kang ^a,c   Liu, Shing Hwa ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cisplatin; Endoplasmic reticulum stress; Free radicals; Nephrotoxicity; Oxidative stress; Salubrinal

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 4; CCAAT ENHANCER BINDING PROTEIN; CISPLATIN; INITIATION FACTOR 2; KIDNEY INJURY MOLECULE 1; MALONALDEHYDE; SALUBRINAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOPATHOLOGY; LIPID PEROXIDATION; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RENAL PROTECTION; UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; CELL LINE; CINNAMATES; CISPLATIN; DRUG SYNERGISM; EUKARYOTIC INITIATION FACTOR-2; HUMANS; KIDNEY; MICE; MICE, INBRED ICR; MODELS, ANIMAL; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; THIOUREA;

EUKARYOTA; MUS;

EID: 79959919089     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.038     Document Type: Article

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