Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56 lck in human Jurkat T cells

Biochemical Pharmacology

Volumn 82, Issue 9, 2011, Pages 1110-1125

  Park, Hae Sun ^a   Jun, Do Youn ^a   Han, Cho Rong ^a   Woo, Hyun Ju ^a   Kim, Young Ho ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Apoptosis; ER stress; Mitochondria dependent caspase cascade; p56 lck; Proteasome inhibitor

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAK; PROTEIN BCL XL; PROTEIN BID; PROTEIN KINASE LCK; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL VIABILITY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

APOPTOSIS; BCL-X PROTEIN; CASPASES; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JURKAT CELLS; LEUPEPTINS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MAP KINASE KINASE 4; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; STRESS, PHYSIOLOGICAL;

EID: 80053969555     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.07.085     Document Type: Article

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