Ligand screening system using fusion proteins of G protein-coupled receptors with G protein α subunits

Neurochemistry International

Volumn 51, Issue 2-4 SPEC. ISS., 2007, Pages 140-164

  Suga, Hinako ^a   Haga, Tatsuya ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

Fusion protein; G protein; G protein coupled receptor; Ligand screening

Indexed keywords

5 OXO EICOSATETRAENOIC ACID; [4 [(3 CHLOROPHENYL)CARBAMOYLOXY] 2 BUTYNYL]TRIMETHYLAMMONIUM; ACETYLCHOLINE; ARACHIDONIC ACID DERIVATIVE; ATROPINE; BETA2 ADRENOCEPTOR GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT FUSION PROTEIN; CARBACHOL; DOCOSAHEXAENOIC ACID; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GAMMA LINOLENIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HYBRID PROTEIN; ICOSAPENTAENOIC ACID; ICOSATRIENOIC ACID; LIGAND; MUSCARINIC AGENT; NOCICEPTIN RECEPTOR GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT FUSION PROTEIN; PERTUSSIS TOXIN; PILOCARPINE; SEROTONIN 1A RECEPTOR GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT FUSION PROTEIN; UNCLASSIFIED DRUG;

DESENSITIZATION; DRUG MECHANISM; GENE IDENTIFICATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC SCREENING; GENETIC TRAIT; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW;

ANIMALS; BIOLOGICAL ASSAY; DRUG EVALUATION, PRECLINICAL; GENOME, HUMAN; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; LIGANDS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS;

EID: 34547471030     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2007.06.006     Document Type: Review

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