Medicine: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake

Science

Volumn 310, Issue 5750, 2005, Pages 996-999

  Zhang, Jian V ^a   Ren, Pei Gen ^a   Avsian Kretchmer, Orna ^a   Luo, Ching Wei ^a   Rauch, Rami ^a   Klein, Cynthia ^a   Hsueh, Aaron J W ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOOD PRODUCTS; GENES; HORMONES; MEDICINE; PROTEINS;

GHRELIN; OBESTATIN; POSTRANSLATIONAL PROCESSING;

POLYPEPTIDES;

ANOREXIGENIC AGENT; APPETITE STIMULANT; BETA ACTIN; COMPLEMENTARY DNA; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GHRELIN; GLYCINE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HORMONE ANTIBODY; HORMONE PRECURSOR; IODINE 125; MESSENGER RNA; MOTILIN; NEUROMEDIN U; NEUROTENSIN; OBESTATIN; PEPTIDE HORMONE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; GPR39 PROTEIN, HUMAN; LIGAND; OBESTATIN, HUMAN; OBESTATIN, RAT; PROTEIN PRECURSOR;

MEDICINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BIOINFORMATICS; CHO CELL; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; GENE SEQUENCE; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE RECEPTOR INTERACTION; HORMONE RELEASE; HUMAN; HUMAN CELL; INTESTINE CONTRACTION; JEJUNUM CONTRACTION; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RADIOIMMUNOASSAY; RAT; RECEPTOR OCCUPANCY; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SERUM RESPONSIVE ELEMENT; WEIGHT REDUCTION; ANIMAL; BIOLOGY; BLOOD; C57BL MOUSE; CHEMISTRY; DIET RESTRICTION; DRUG EFFECT; EATING; GASTROINTESTINAL MOTILITY; GENETICS; HAMSTER; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STOMACH EMPTYING; WEIGHT GAIN;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; CRICETINAE; EATING; FASTING; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PEPTIDE HORMONES; PROTEIN BINDING; PROTEIN PRECURSORS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; WEIGHT GAIN;

EID: 27744600963     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1117255     Document Type: Article

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28. We thank S. Y. Hsu for bioinformatic consultation; the Protein and Nucleic Acid facility at Stanford University for peptide sequencing; N. Shankley for hormone name suggestion; and B. Kobilka, M. Poo, and A. Payne for comments on the manuscript. This work was supported by Johnson & Johnson Pharmaceutical Research and Development Animal care was consistent with Stanford University guidelines. The GenBank accession number for human ghrelin is NP_057446.