The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain

Molecular Pharmacology

Volumn 53, Issue 4, 1998, Pages 778-786

  Parmentier, Marie Laure ^a,b   Joly, Cécile ^a   Restituito, Sophie ^a   Bockaert, Joël ^a   Grau, Yves ^a   Pin, Jean Philippe ^a,c  

^a INSERM   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CCIPE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE HOMOLOGY;

EID: 0031957702     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.4.778     Document Type: Article

References (38)

1. Acher F, Teiller F, Azerad R, Brabet I, Fagni L, and Pin J-P (1997) Synthesis and pharmacological characterization of aminocyclopentane tricarboxylic acids (ACPT): new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem 40:3119-3129.
2. Amatruda TT III, Steele DA, Slepak VZ, and Simon MI (1991) Gα16, a G protein α subunit specifically expressed in hematopoietic cells. Proc Natl Acad Sci USA 88:5587-5591.
3. 2+-sensing receptor from bovine parathyroid. Nature (Lond) 366:575-580.
4. Burstein ES, Spalding TA, and Brann MR (1996) Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins. Mol Pharmacol 51:312-319.
5. Conklin BR and Bourne HR (1993) Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors. Cell 73:631-641.
6. Conklin BR, Farfel Z, Lustig KD, Julius D, and Bourne HR (1993) Substitution of three amino acids switches receptor specificity of Gqα to that of Giα. Nature (Lond) 363:274-276.
7. sα that alter the fidelity of receptor activation. Mol Pharmacol 50:885-890.
8. Conn P and Pin J-P (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxical 37:205-237.
9. Dratz EA, Furstenau JE, Lambert CG, Thireault DL, Rarick H, Schepers T, Pakhlevaniants S, and Hamm HE (1993) NMR structure of a receptor-bound G-protein peptide. Nature (Lond) 383:276-281.
10. Dulac C and Axel R (1995) A novel family of genes encoding putative pheromone receptors in mammals. Cell 83:195-206.
11. s. Mol Pharmacol 45: 696-702.
12. 2 adrenergic receptor: evidence for ligand-specific conformational changes. J Biol Chem 270:28268-28275.
13. Gomeza J, Joly C, Kuhn R, Knöpfel T, Bockaert J, and Pin J-P (1996a) The second intracellular loop of mGluR1 cooperates with the other intracellular domains to control coupling to G-protein. J Biol Chem 271:2199-2205.
14. αq/i proteins: characterization of new antagonists. Mol Pharmacol 50:923-930.
15. Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, and Hofmann KP (1988) Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit. Science (Washington DC) 241:832-835.
16. Herrada G and Dulac C (1997) A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell 90:763-773.
17. Hinton DR, Blanks JC, Fong HKW, Casey PJ, Hildebrandt E, and Simons MI (1990) Novel localization of a G protein, Gz-α, in neurons of brain and retina. J Neurosci 10:2763-2770.
18. Joly C, Gomeza J, Brabet I, Curry K, Bockaert J, and Pin JP (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. J Neurosci 15:3970-3981.
19. B receptors uncovers similarity to metabotropic glutamate receptors. Nature (Lond) 386:239-246.
20. α16 contribute to the specificity of activation by the C5a receptor. Mol Pharmacol 47:218-223.
21. Lichtarge O, Bourne HR, and Cohen FE (1996) Evolutionarily conserved Gαβγ binding surfaces support a model of the protein-receptor complex. Proc Natl Acad Sci USA 93:7507-7511.
22. Liu J, Conklin BR, Blin N, Yun J, and Wess J (1995) Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proc Natl Acad Sci USA 92:11642-11646.
23. Mary S, Gomeza J, Prézeau L, Bockaert J, and Pin J-P (1998) A cluster of basic residues in the carboxy-terminal tail of the short mGluR1 variants impairs their coupling to PLC. J Biol Chem 273:425-432.
24. Matsunami H and Buck LB (1997) A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 90:775-784.
25. Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science (Washington DC) 258:597-603.
26. O'Hara PJ, Sheppard PO, Thøgersen H, Venezia D, Haldeman BA, McGrane V, Houamed KM, Thomsen C, Gilbert TL, and Mulvihill ER (1993) The ligandbinding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11:41-52.
27. Offermanns S and Simon MI (1995) Gα15 and Gα16 couple a wide variety of receptors to phospholipase C. J Biol Chem 270:15175-15180.
28. Parmentier M-L, Pin J-P, Bockaert J, and Grau Y (1996) Cloning and functional expression of a Drosophila metabotropic receptor expressed in the embryonic central nervous system. J Neurosci 16:6687-6694.
29. Perez DM, Hwa J, Gaivin R, Mathur M, Brown M, and Graham RM (1996) Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor. Mol Pharmacol 49:112-122.
30. Pin J-P, Joly C, Heinemann SF, and Bockaert J (1994) Domains involved in the specificity of G protein activation in phospholipase C coupled metabotropic glutamate receptor. EMBO J 13:342-348.
31. Prézeau L, Gomeza J, Ahern S, Mary S, Galvez T, Bockaert J, and Pin J-P (1996) Changes in the carboxy-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors differing by agonist-independant activity Mol Pharmacol 49:422-429.
32. Robb S, Cheek TR, Hannan FL, Hall LM, Midgley JM, and Evans PD (1994) Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. EMBO J 13:1325-1330.
33. Savarese TM and Fraser CM (1992) In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem J 283:1-19.
34. Spengler D, Waeber C, Pantaloni C, Holsboer F, Bockaert J, Seeburg PH, and Journot L (1993) Differential signal transduction by five splice variants of the PACAP receptor. Nature (Lond) 366:170-175.
35. Takahashi K, Tsuchida K, Tanabe Y, Masu M, and Nakanishi S (1993) Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J Biol Chem 268:19341-19345.
36. Tones MA, Bendali H, Flor PJ, Knopfel T, and Kuhn R (1995) The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. Neuroreport 7:117-120.
37. Wilkie TM, Scherle PA, Strathmann MP, Slepak VZ, and Simon MI (1991) Characterization of G-protein α subunits in the Gq class: expression in murine tissue and in stromal and hematopoetic cell lines. Proc Natl Acad Sci USA 88:10049-10053.
38. Wong YH, Conklin BR, and Bourne HR (1992) Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science (Washington DC) 255:339-342.