TG1019/OXE, a Gαi/o-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis

Biochemical and Biophysical Research Communications

Volumn 334, Issue 4, 2005, Pages 987-995

  Hosoi, Takeshi ^a   Sugikawa, Emiko ^a   Chikada, Aiko ^a   Koguchi, Yutaka ^a   Ohnuki, Tetsuo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

5 Oxo ETE; Calcium mobilization; Chemotaxis; ERK; GPCR; Lipid mediator; LY294002; OXE; Phospholipase C; PI3K; TG1019; U73122

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 OXOEICOSATETRAENOIC ACID; G PROTEIN COUPLED RECEPTOR; ICOSATRIENOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG; 5 OXO 6,8,11,14 ICOSATETRAENOIC ACID; 5-OXO-6,8,11,14-EICOSATETRAENOIC ACID; ARACHIDONIC ACID DERIVATIVE; OXER1 PROTEIN, HUMAN; RECEPTOR; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL ACTIVATION; CELL STIMULATION; CHEMOTAXIS; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; GENETIC TRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; CRICETULUS; DOSE RESPONSE; DRUG EFFECT; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY;

CRICETULUS GRISEUS;

ANIMALS; ARACHIDONIC ACIDS; CHEMOTAXIS; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; RECEPTORS, EICOSANOID; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS;

EID: 23044469567     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.06.191     Document Type: Article

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