Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Nature

Volumn 429, Issue 6988, 2004, Pages 188-193

  He, Welhal ^a,c   Miao, Frederick J P ^a   Lin, Daniel C H ^a   Schwandner, Ralf T ^a,b   Wang, Zhulun ^a   Gao, Jinhal ^a,d   Chen, Jin Long ^a   Tlan, Hui ^a   Ling, Lei ^a  

^a AMGEN INC   (United States)

^b Tularik GmbH   (Germany)

^c Genospectra Inc   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; DISEASES; METABOLISM; PROTEINS; RESPIRATORY SYSTEM;

CITRIC ACID CYCLE; ENERGY HOMEOSTASIS; G-PROTEIN-COUPLED RECEPTORS (GPCR);

INORGANIC ACIDS;

G PROTEIN COUPLED RECEPTOR; PROTEIN; PROTEIN GPR91; PROTEIN GPR99; UNCLASSIFIED DRUG;

BIOCHEMICAL PHENOMENA; CITRIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BREATHING; CATALYSIS; CELL METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; ENERGY METABOLISM; HYPERTENSION; KIDNEY FAILURE; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR HYPERTENSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CAPTOPRIL; CATTLE; CELL LINE; CITRIC ACID CYCLE; CRICETINAE; HUMANS; HYPERTENSION; KETOGLUTARIC ACIDS; KIDNEY; LIGANDS; MICE; MODELS, MOLECULAR; PERTUSSIS TOXIN; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RENIN-ANGIOTENSIN SYSTEM; RHODOPSIN; RNA, MESSENGER; SUCCINIC ACID; SWINE;

ANIMALIA;

EID: 2442649129     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02488     Document Type: Article

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