Identification of Gβγ binding sites in the third intracellular loop of the M3-muscarinic receptor and their role in receptor regulation

Journal of Biological Chemistry

Volumn 275, Issue 12, 2000, Pages 9026-9034

  Wu, Guangyu ^a   Bogatkevich, Galina S ^a   Mukhin, Yurii V ^b   Benovic, Jeffrey L ^c   Hildebrandt, John D ^a   Lanier, Stephen M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; CYSTEINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GLUTAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTIDINE; MUSCARINIC M3 RECEPTOR; PHENYLALANINE; PROTEIN KINASE; BETA ADRENERGIC RECEPTOR KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN BETA GAMMA; G-PROTEIN BETA GAMMA; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC RECEPTOR; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; SERINE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; GENETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID SEQUENCE; BETA-ADRENERGIC RECEPTOR KINASE; BINDING SITES; BIOLOGICAL TRANSPORT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; GTP-BINDING PROTEINS; HETEROTRIMERIC GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; RECOMBINANT PROTEINS; SERINE; SIGNAL TRANSDUCTION;

EID: 0034708266     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.12.9026     Document Type: Article

References (62)

1. Coulter, S., and Rodbell, M. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 5842-5846
2. Vaillancourt, R. R., Dhanasekaran, N., Johnson, G. L., and Ruoho, A. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3645-3649
3. Zeng, F.-Y., and Wess, J. (1999) J. Biol. Chem. 274, 19487-19497
4. Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R., Karschin, A., and Bettler, B. (1998) Nature 396, 683-687
5. Ausiello, D. A., Stow, J. L., Cantiello, H. F., de Almeida, J. B., and Benos, D. J. (1992) J. Biol. Chem. 267, 4759-4765
6. Ali, M. S., Sayeski, P. P., Dirksen, L. B., Hayzer, D. J., Marrero, M. B., and Bernstein, K. E. (1997) J. Biol. Chem. 272, 23382-23388
7. Mitchell, R., McCulloch, D., Lutz, E., MacKenzie, C., Fennell, M., Fink, G., Zhou, W., and Sealfon, S. C. (1998) Nature 392, 411-414
8. Luttrell, L. M., Ferguson, S. S. G., Daaka, Y., Miller, W. E., Maudsley, S., Della Rocca, G. J., Lin, F. T., Kawakatsu, H., Owada, K., Luttrell, D. K., Caron, M. G., and Lefkowitz, R. J. (1999) Science 283, 655-661
9. Sato, M., Kataoka, R., Dingus, J., Wilcox, M., Hildebrandt, J.D., and Lanier, S. M. (1995) J. Biol. Chem. 270, 15269-15276
10. Sato, M., Ribas, C., Hildebrandt, J. D., Lanier, S. M. (1996) J. Biol. Chem. 271, 30052-30060
11. Takesono, A., Cismowski, M. J., Ribas, C., Bernard, M., Chung, P., Hazard, S., III, Duzic, E., and Lanier, S. M. (1999) J. Biol. Chem. 274, 33202-33205
12. Cismowski, M., Takesono, A., Ma, C., Fuernkranz, H., Lanier, S. M., and Duzic, E. (1999) Nature Biotechnol. 17, 878-883
13. Dohlman, H. G., and Thorner, J. (1997) J. Biol. Chem. 272, 3871-3874
14. Li, S., Okamoto, T., Chun, M., Sargiacomo, M., Casonova, J. E., Hansen, S. H., Nishimoto, I., and Lisanti, M. P. (1995) J. Biol. Chem. 270, 15693-15701
15. Okamoto, T., Takeda, S., Murayama, Y., Ogata, E., and Nishimoto, I. (1995) J. Biol. Chem. 270, 4205-4208
16. Boekhoff, I., Touhara, K., Danner, S., Inglese, J., Lohse, M. J., Breer, H., and Lefkowitz, R. J. (1997) J Biol Chem 272, 4606-4612
17. Roychowdhury, S., Wang, N., and Rasenick, M. M. (1993) Biochemistry 32, 4955-4961
18. Strittmatter, S. M., Valenzuela, D., Sudo, Y., Linder, M. E., Fishman, M. C. (1991) J. Biol. Chem. 266, 22465-22471
19. Luo, Y., and Denker, B. M. (1999) J. Biol. Chem. 274, 10685-10688
20. Wu, G., Krupnick, J. G., Benovic, J. L., and Lanier, S. M. (1997) J. Biol. Chem. 272, 17836-17842
21. Wu, G., Benovic, J. L., Hildebrandt, J. D., and Lanier, S. M. (1998) J. Biol. Chem. 273, 7197-7200
22. Brakeman, P. R., Lanahan, A. A., O'Brien, R., Roche, K., Barnes, C. A., Huganir, R. L., and Worley, P. F. (1997) Nature 386, 284-288
23. Klein, U., Ramirez, M. T., Kobilka, B. K., and von Zastrow, M. (1997) J. Biol. Chem. 272, 19099-19102
24. Mochizuki, N., Cho, G., Wen, B., and Insel, P. A. (1996) Gene 181, 39-43
25. Mochizuki, N., Hibi, M., Kanai, Y., and Insel, P. A. (1995) FEBS Lett. 373, 155-158
26. Hall, R. A., Premont, R. T., Chow, C.-W., Blitzer, J. T., Pitcher, J. A., Claing, A., Stoffel, R. H., Barak, L. S., Shenolikar, S., Weinman, E. J., Grinstein, S., and Lefkowitz, R. J. (1998) Nature 392, 626-630
27. Dingus, J., Wilcox, M. D., Kohnken, R., and Hildebrandt, J. D. (1994) Methods Enzymol. 237, 457-471
28. Makhlouf, M., Ashton, S. H., Hildebrandt, J. D., Mehta, N., Gettys, T. W., Halushka, P. V., and Cook, J. A. (1996) Biochim. Biophys. Acta 1312, 163-168
29. Kim, C. M., Dion, S. B., Onoraro, J. J., and Benovic, J. L. (1993) Receptor 3, 39-55
30. Lanier, S. M., Downing, S., Duzic, E., and Homcy, C. J. (1991) J. Biol. Chem. 266, 10470-10478
31. Schroeder, K. S., and Neagle, B. D. (1996) J. Biomol. Screening 1, 75-80
32. Porter, R. H. P., Benwell, K. R., Lamb, H., Malcolm, C. S., Allen, N. H., Revell, D. F., Adams, D. R., and Sheardown, M. J. (1999) Br. J. Pharmacol. 128, 13-20
33. Moro, O., Lameb, J., and Sadée, W. (1993) J. Biol. Chem. 268, 6862-6865
34. Bogatkevich, G. S., Lenz, W., Jakobs, K. H., and van Koppen, C. J. (1996) Mol. Pharmacol. 50, 424-429
35. Onorato, J. J., Palczewski, K., Regan, J. W., Caron, M. G., Lefkowitz, R. J., and Benovic, J. L. (1991) Biochemistry 30, 5118-5125
36. Eason, M. G., Moreira, S. P., and Liggett, S. B. (1995) J. Biol. Chem. 270, 4681-4688
37. Pals-Rylaarsdam, R., and Hosey, M. M. (1997) J. Biol. Chem. 272, 14152-14158
38. Kim, C. M., Dion, S. B., and Benovic, J. L. (1993) J. Biol. Chem. 268, 15412-15418
39. Gurevich, V. V., Pals-Rylaarsdam, R., Benovic, J. L., Hosey, M. M., and Onorato, J. J. (1997) J. Biol. Chem. 272, 28849-28852
40. Goodman, O. B., Jr., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1996) Nature 383, 447-450
41. LaPorte, S. A., Oakley, R. H., Zhang, J., Holt, J. A., Ferguson, S. S. G., Caron, M. G., and Barak, L. S. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3712-3717
42. Kelleher, D. J., and Johnson, G. L. (1988) Mol. Pharmacol. 34, 452-460
43. Phillips, W. J., and Cerione, R. A. (1992) J. Biol. Chem. 267, 17032-17039
44. Halpern, J. L., Chang, P. C., Tsai, S., Adamik, R., Kanaho, Y., Sohn, R., Moss, J., and Vaughan, M. (1987) Biochem. 26, 1655-1658
45. Kurstjens, N. P., Frohlich, M., Dees, C., Cantrill, R. C., Hekman, M., and Helmreich, E. J. M. (1991) Eur. J. Biochem. 197, 167-176
46. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G., and Wittig, B. (1992) Science 358, 424-426
47. Taylor, J. M., Jacob-Mosier, G. G., Lawton, R. G., Remmers, A. E., and Neubig, R. R. (1994) J. Biol. Chem. 269, 27618-27624
48. Hildebrandt, J. D. (1997) Biochem. Pharmacol. 54, 325-339
49. Richardson, M., and Robishaw, J. D. (1999) J. Biol. Chem. 274, 13525-13533
50. Debburman, S. K., Kunapuli, P., Benovic, J. L., and Hosey, M. M. (1995) Mol. Pharmacol. 47, 224-233
51. Tobin, A. B., Totty, N. F., Sterlin, A. E., and Nahorski, S. R. (1997) J. Biol. Chem. 272, 20844-20849
52. Budd, D. C., Rae, A., and Tobin, A. B. (1999) J. Biol. Chem. 274, 12355-12360
53. Haga, K., and Haga, T. (1992) J. Biol. Chem. 267, 2222-2227
54. Lin, H. C. Duncan, J. A., Kozasa, T., and Gilman, A. G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5057-5060
55. Ferguson, S. S. G., Ménard, L., Barak, L. S., Koch, W. J., Colapietro, A.-M., and Caron, M. G. (1995) J. Biol. Chem. 270, 24782-24789
56. K. Ito, Haga, T., Lameh, J., and Sadée, W. (1999) Eur. J. Biochem. 260, 112-119
57. Lee, K. B., Pals-Rylaarsdam, R., Benovic, J. L., and Hosey, M. M. (1998) J. Biol. Chem. 273, 12967-12972
58. Vögler, O., Nolte, B., Voss, M., Schmidt, M., Jakobs, K. H., and van Koppen, C. J. (1999) J. Biol. Chem. 274, 12333-12338
59. Hirofumi, T., Okuno, E., Kameyama, K., and Haga, T. (1998) J. Pharmacol. Exp. Ther. 284, 1218-1226
60. DeGraff, J. L., Gagnon, A. W., Benovic, J. L., and Orsini, M. J. (1999) J. Biol. Chem. 274, 11253-11259
61. Zhang, J., Ferguson, S. S. G., Barak, L. S., Bodduluri, S. R., LaPorte, S. A., Law, P.-Y., and Caron, M. G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7159-7162
62. Maggio, R., Barbier, P., Fornai, F., and Corsini, G. U. (1996) J. Biol. Chem. 271, 31055-31060