Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

Trends in Pharmacological Sciences

Volumn 26, Issue 3, 2005, Pages 131-137

  Bulenger, Sébastien ^a   Marullo, Stefano ^a   Bouvier, Michel ^b  

^a INSTITUT COCHIN   (France)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; DIMER; G PROTEIN COUPLED RECEPTOR;

CELL MEMBRANE; CELL SURFACE; DIMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; QUALITY CONTROL; REVIEW; SIGNAL TRANSDUCTION;

EID: 14644387575     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2005.01.004     Document Type: Review

References (90)

1. M. Bouvier Oligomerization of G-protein-coupled transmitter receptors Nat. Rev. Neurosci. 2 2001 274 286
2. K.M. Kroeger G-protein coupled receptor oligomerization in neuroendocrine pathways Front. Neuroendocrinol. 24 2003 254 278
3. G.E. Breitwieser G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling Circ. Res. 94 2004 17 27
4. M. Bai Dimerization of G-protein-coupled receptors: roles in signal transduction Cell. Signal. 16 2004 175 186
5. B receptors - the first 7TM heterodimers Trends Pharmacol. Sci. 20 1999 396 399
6. S. Angers Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function Annu. Rev. Pharmacol. Toxicol. 42 2002 409 435
7. K.A. Eidne Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells Trends Endocrinol. Metab. 13 2002 415 421
8. S.R. George G-protein-coupled receptor oligomerization and its potential for drug discovery Nat. Rev. Drug Discov. 1 2002 808 820
9. D.L.Y. Fotiadis Atomic-force microscopy: rhodopsin dimers in native disc membranes Nature 421 2003 127 128
10. K. Palczewski Crystal structure of rhodopsin: a G protein-coupled receptor Science 289 2000 739 745
11. J. Sondek Crystal structure of a G-protein beta gamma dimer at 2.1A resolution Nature 379 1996 369 374
12. D.G. Lambright The 2.0 A crystal structure of a heterotrimeric G protein Nature 379 1996 311 319
13. H.E. Hamm How activated receptors couple to G proteins Proc. Natl. Acad. Sci. U. S. A. 98 2001 4819 4821
14. J.L. Baneres, and J. Parello Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein J. Mol. Biol. 329 2003 815 829
15. J. Kniazeff Closed state of both binding domains of homodimeric mGlu receptors is required for full activity Nat. Struct. Mol. Biol. 11 2004 706 713
16. J.P. Pin Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors Pharmacol. Ther. 98 2003 325 354
17. F.Y. Zeng, and J. Wess Identification and molecular characterization of m3 muscarinic receptor dimers J. Biol. Chem. 274 1999 19487 19497
18. M. McVey Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy J. Biol. Chem. 276 2001 14092 14099
19. M.C. Overton, and K.J. Blumer G-protein-coupled receptors function as oligomers in vivo Curr. Biol. 10 2000 341 344
20. M.A. Ayoub Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer J. Biol. Chem. 277 2002 21522 21528
21. H. Issafras Constitutive agonist-independent CCR5 oligomerization and antibody- mediated clustering occurring at physiological levels of receptors J. Biol. Chem. 277 2002 34666 34673
22. A.A. Jensen Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) Eur. J. Biochem. 269 2002 5076 5087
23. S. Terrillon Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis Mol. Endocrinol. 17 2003 677 691
24. G.J. Babcock Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor J. Biol. Chem. 278 2003 3378 3385
25. A. Salahpour Homodimerization of the {beta}2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting J. Biol. Chem. 279 2004 33390 33397
26. L.F. Agnati Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons Pharmacol. Rev. 55 2003 509 550
27. (B) receptor heterodimerization Neuron 27 2000 97 106
28. J. Bockaert, and J.P. Pin Molecular tinkering of G protein-coupled receptors: an evolutionary success EMBO J. 18 1999 1723 1729
29. C. Hague Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors J. Biol. Chem. 279 2004 15541 15549
30. C. Hague Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor Proc. Natl. Acad. Sci. U. S. A. 101 2004 13672 13676
31. G. Nelson Mammalian sweet taste receptors Cell 106 2001 381 390
32. G. Nelson An amino-acid taste receptor Nature 416 2002 199 202
33. M. Benkirane Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32 J. Biol. Chem. 272 1997 30603 30606
34. T. Shioda Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5 J. Virol. 75 2001 3462 3468
35. A. Kaykas Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization Nat. Cell Biol. 6 2004 52 58
36. M.C. Overton Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor J. Biol. Chem. 278 2003 49369 49377
37. T.E. Hebert A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation J. Biol. Chem. 271 1996 16384 16392
38. J. Bass Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization J. Cell Biol. 141 1998 637 646
39. J.J. Wu, and G. Guidotti Proreceptor dimerization is required for insulin receptor post-translational processing J. Biol. Chem. 279 2004 25765 25773
40. J. Gent Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis Proc. Natl. Acad. Sci. U. S. A. 99 2002 9858 9863
41. L. Gilboa Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane J. Cell Biol. 140 1998 767 777
42. N. Zerangue A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels Neuron 22 1999 537 548
43. D.M. Papazian Potassium channels: some assembly required Neuron 23 1999 7 10
44. P.S. Reddy, and R.B. Corley Assembly, sorting, and exit of oligomeric proteins from the endoplasmic reticulum Bioessays 20 1998 546 554
45. L. Ellgaard, and A. Helenius Quality control in the endoplasmic reticulum Nat. Rev. Mol. Cell Biol. 4 2003 181 191
46. H. Yuan 14-3-3 dimers probe the assembly status of multimeric membrane proteins Curr. Biol. 13 2003 638 646
47. L. Prezeau The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes J. Biol. Chem. 274 1999 13462 13469
48. (B) receptors and members of the 14-3-3 family of signaling proteins Mol. Cell. Neurosci. 17 2001 317 328
49. H. Tazawa Interaction of the parathyroid hormone receptor with the 14-3-3 protein Biochim. Biophys. Acta 1620 2003 32 38
50. E.K. Baker The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin EMBO J. 13 1994 4886 4895
51. J.P. Chapple, and M.E. Cheetham The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation J. Biol. Chem. 278 2003 19087 19094
52. J.C. Bermak Regulation of transport of the dopamine D1 receptor by a new membrane- associated ER protein Nat. Cell Biol. 3 2001 492 498
53. L.M. McLatchie RAMPs regulate the transport and ligand specificity of the calcitonin- receptor-like receptor Nature 393 1998 333 339
54. P.M. Sexton Receptor activity modifying proteins Cell. Signal. 13 2001 73 83
55. J. Loconto Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules Cell 112 2003 607 618
56. A.A. Gimelbrant Olfactory receptor trafficking involves conserved regulatory steps J. Biol. Chem. 276 2001 7285 7290
57. N.D. Dwyer Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein Cell 93 1998 455 466
58. S. AbdAlla Involvement of the amino terminus of the B(2) receptor in agonist- induced receptor dimerization J. Biol. Chem. 274 1999 26079 26084
59. J.M. Rodriguez-Frade The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2 Proc. Natl. Acad. Sci. U. S. A. 96 1999 3628 3633
60. M. Rocheville Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers J. Biol. Chem. 275 2000 7862 7869
61. A.J. Vila-Coro HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization Proc. Natl. Acad. Sci. U. S. A. 97 2000 3388 3393
62. R.D. Horvat Binding of agonist but not antagonist leads to fluorescence resonance energy transfer between intrinsically fluorescent gonadotropin- releasing hormone receptors Mol. Endocrinol. 15 2001 695 703
63. S. Terrillon, and M. Bouvier Roles of G-protein-coupled receptor dimerization EMBO Rep. 5 2004 30 34
64. J.P. Vilardaga Measurement of the millisecond activation switch of G protein-coupled receptors in living cells Nat. Biotechnol. 21 2003 807 812
65. M. Rocheville Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity Science 288 2000 154 157
66. K.M. Kroeger Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer J. Biol. Chem. 276 2001 12736 12743
67. R.C. Patel Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells Proc. Natl. Acad. Sci. U. S. A. 99 2002 3294 3299
68. M.A. Ayoub Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared to MT2 homodimers Mol. Pharmacol. 66 2004 312 321
69. A. Breit Heterodimerization between beta 2- and beta 3-adrenergic receptors generates a beta -adrenergic signalling unit with distinct functional properties J. Biol. Chem. 279 2004 28756 28765
70. S. AbdAlla AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration Nature 407 2000 94 98
71. F. Ciruela Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes J. Biol. Chem. 276 2001 18345 18351
72. S. AbdAlla Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness Nat. Med. 7 2001 1003 1009
73. D. Ramsay Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences Biochem. J. 365 2002 429 440
74. J.F. Mercier Quantitative assessment of beta 1 and beta 2-adrenergic receptor homo and hetero-dimerization by bioluminescence resonance energy transfer J. Biol. Chem. 277 2002 44925 44931
75. K. Ray Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor J. Biol. Chem. 274 1999 27642 27650
76. N. Kunishima Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor Nature 407 2000 971 977
77. Z. Zhang The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions J. Biol. Chem. 276 2001 5316 5322
78. (B) receptors J. Neurosci. 21 2001 1189 1202
79. S. Cvejic, and L.A. Devi Dimerization of the delta opioid receptor: implication for a role in receptor internalization J. Biol. Chem. 272 1997 26959 26964
80. P. Hernanz-Falcon Identification of amino acid residues crucial for chemokine receptor dimerization Nat. Immunol. 5 2004 216 223
81. S.P. Lee D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4 Biochemistry 42 2003 11023 11031
82. J.J. Carrillo Multiple interactions between transmembrane helices generate the oligomeric {alpha}1b-adrenoceptor Mol. Pharmacol. 66 2004 1123 1137
83. W. Guo The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer J. Biol. Chem. 278 2003 4385 4388
84. P.R. Gouldson Lipid-facing correlated mutations and dimerization in G-protein coupled receptors Protein Eng. 14 2001 759 767
85. M.K. Dean Dimerization of G-protein-coupled receptors J. Med. Chem. 44 2001 4595 4614
86. M. Filizola Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method Protein Eng. 15 2002 881 885
87. B.A. Jordan, and L.A. Devi G-protein-coupled receptor heterodimerization modulates receptor function Nature 399 1999 697 700
88. D. Michaelson Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi Mol. Biol. Cell 13 2002 3294 3302
89. S. Takida, and P.B. Wedegaertner Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma J. Biol. Chem. 278 2003 17284 17290
90. S. Takida, and P.B. Wedegaertner Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins FEBS Lett. 567 2004 209 213