Effects of partial agonists and Mg2+ ions on the interaction of M2 muscarinic acetylcholine receptor and G protein Gαi1 subunit in the M2Gαi1 protein

Journal of Biochemistry

Volumn 135, Issue 5, 2004, Pages 589-596

  Zhan, Qingli ^a,d   Okamura, Michiko ^a   Guo, Zeng Dong ^a,e   Niwa, Shunsuke ^b,c,f   Haga, Tatsuya ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b GAKUSHUIN UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e CHINA MEDICAL UNIVERSITY   (China)

^f Amano Watanabe and Associates   (Japan)

Author keywords

Fusion protein; G protein coupled receptor; Mg2+ion; Muscarinic acetylcholine receptor; Partial agonist

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HYBRID PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA1 SUBUNIT; LIGAND; MAGNESIUM CHLORIDE; MAGNESIUM ION; MUSCARINIC M2 RECEPTOR AGONIST; PARTIAL AGONIST; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; GLYCOSYLATION; INSECT CELL; LIGAND BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING;

ALTERNATIVE SPLICING; ANIMALS; BACULOVIRIDAE; BIOCHEMISTRY; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; INSECTS; IONS; LIGANDS; MAGNESIUM; MAGNESIUM CHLORIDE; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, MUSCARINIC M2; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

INSECTA;

EID: 3042791050     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvh072     Document Type: Article

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