G-protein coupled receptor kinases as modulators of G-protein signalling

Journal of Physiology

Volumn 517, Issue 1, 1999, Pages 5-23

  Bünemann, Moritz ^a   Hosey, M Marlene ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOTRANSFERASE; RETINA S ANTIGEN; UNCOUPLING PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; MUSCARINIC M2 RECEPTOR;

PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; IN VIVO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

ANIMALS; ARRESTIN; ENDOCYTOSIS; GTP-BINDING PROTEINS; HUMANS; MODELS, BIOLOGICAL; PROTEIN CONFORMATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CELL SURFACE; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION;

EID: 0344780741     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.0005z.x     Document Type: Review

References (178)

1. AKHTER, S. A., SKAER, C. A., KYPSON, A. P., MCDONALD, P. H., PEPPEL, K. C., GLOWER, D. D., LEFKOWITZ, R. J. & KOCH, W. J. (1997). Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proceedings of the National Academy of Sciences of the USA 94, 12100-12105.
2. ALTSCHULER, Y., BARBAS, S. M., TERLECKY, L. J., TANG, K., HARDY, S., MOSTOV, K. E. & SCHMID, S. L. (1998). Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. Journal of Cell Biology 143, 1871-1881.
3. APPLEYARD, S. M., PATTERSON, T. A., JIN, W. & CHAVKIN, C. (1997). Agonist-induced phosphorylation of the κ-opioid receptor. Journal of Neurochemistry 69, 2405-2412.
4. ARAGAY, A. M., MELLADO, M., FRADE, J. M., MARTIN, A. M., JIMENEZ-SAINZ, M. C., MARTINEZ, A. C. & MAYOR, F. JR (1998a). Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proceedings of the National Academy of Sciences of the USA 95, 2985-2990.
5. ARAGAY, A. M., RUIZ-GOMEZ, A., PENELA, P., SARNAGO, S., ELORZA, A., JIMENEZ-SAINZ, M. C. & MAYOR, F. JR (1998b). G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions. FEBS Letters 430, 37-40.
6. ARAMORI, I., ZHANG, J., FERGUSON, S. S., BIENIASZ, P. D., CULLEN, B. R. & CARON, M. G. (1997). Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. EMBO Journal 16, 4606-4616.
7. ARDEN, J. R., SEGREDO, V., WANG, Z., LAMEH, J. & SADEE, W. (1995). Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK 293 cells. Journal of Neurochemistry 65, 1636-1645.
8. BABA, T., DAMKE, H., HINSHAW, J. E., IKEDA, K., SCHMID, S. L. & WARNOCK, D. E. (1995). Role of dynamin in clathrin-coated vesicle formation. Cold Spring Harbor Symposia on Quantitative Biology 60, 235-242.
9. BENOVIC, J. L. & GOMEZ, J. (1993). Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. Journal of Biological Chemistry 268, 19521-19527.
10. BENOVIC, J. L., KUHN, H., WEYAND, I., CODINA, J., CARON, M. G. & LEFKOWITZ, R. J. (1987a). Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proceedings of the National Academy of Sciences of the USA 84, 8879-8882.
11. BENOVIC, J. L., ONORATO, J. J., ARRIZA, J. L., STONE, W. C., LOHSE, M., JENKINS, N. A., GILBERT, D. J., COPELAND, N. G., CARON, M. G. & LEFKOWITZ, R. J. (1991). Cloning, expression, and chromosomal localization of β-adrenergic receptor kinase 2. A new member of the receptor kinase family. Journal of Biological Chemistry 266, 14939-14946.
12. BENOVIC, J. L., REGAN, J. W., MATSUI, H., MAYOR, F. JR, COTECCHIA, S., LEEB-LUNDBERG, L. M., CARON, M. G. & LEFKOWITZ, R. J. (1987b). Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase. Journal of Biological Chemistry 262, 17251-17253.
13. BENOVIC, J. L., STRASSER, R. H., CARON, M. G. & LEFKOWITZ, R. J. (1986). β-Adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proceedings of the National Academy of Sciences of the USA 83, 2797-2801.
14. BERMAN, D. M. & GILMAN, A. G. (1998). Mammalian RGS proteins: barbarians at the gate. Journal of Biological Chemistry 273, 1269-1272.
15. BOGATKEWITSCH, G. S., LENZ, W., JAKOBS, K. H. & VAN KOPPEN, C. J. (1996). Receptor internalization delays m4 muscarinic acetylcholine receptor resensitization at the plasma membrane. Molecular Pharmacology 50, 424-429.
16. BRASS, L. F. (1992). Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation. Journal of Biological Chemistry 267, 6044-6050.
17. BRISTOW, M. R., HERSHBEROER, R. E., PORT, J. D., GILBERT, E. M., SANDOVAL, A., RASMUSSEN, R., CATES, A. E. & FELDMAN, A. M. (1990). β-Adrenergic pathways in nonfailing and failing human ventricular myocardium. Circulation 82, 112-25.
18. + current in cultured guineapig atrial myocytes. Journal of Physiology 494, 351-362.
19. + current in cultured guinea-pig atrial myocytes. Journal of Physiology 501, 549-554.
20. BÜNEMANN, M. & HOSEY, M. M. (1998). Regulators of G protein signaling (RGS) proteins constitutively activate Gβγ-gated potassium channels. Journal of Biological Chemistry 273, 31186-31190.
21. BÜNEMANN, M., LEE, K. B., PALS-RYLAARSDAM, R., ROSEBERRY, A. G. & HOSEY, M. M. (1999). Desensitization of G-protein-coupled receptors in the cardiovascular system. Annual Review of Physiology 61, 169-192.
22. CARMAN, C. V., SOM, T., KIM, C. M. & BENOVIC, J. L. (1998). Binding and phosphorylation of tubulin by G protein-coupled receptor kinases. Journal of Biological Chemistry 273, 20308-20316.
23. 2+-dependent interaction of recoverin with rhodopsin kinase. Journal of Biological Chemistry 270, 18060-18066.
24. CHENG, Z. J., YU, Q. M., WU, Y. L., MA, L. & PEI, G. (1998). Selective interference of β-arrestin κ with K and δ but not μ opioid receptor/G protein coupling. Journal of Biological Chemistry 273, 24328-24333.
25. CHU, P., MURRAY, S., LISSIN, D. & VON ZASTROW, M. (1997). δ and κ opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. Journal of Biological Chemistry 272, 27124-27130.
26. CHUANG, T. T., LEVINE, H. III & DE BLASI, A. (1995). Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C. Journal of Biological Chemistry 270, 18660-18665.
27. CIRUELA, F., SAURA, C., CANELA, E. I., MALLOL, J., LLUIS, C. & FRANCO, R. (1997). Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors. Molecular Pharmacology 52, 788-797.
28. B receptors reflects differential receptor phosphorylation. Biochemistry 36, 13325-13332.
29. CRESPO, P., XU, N., SIMONDS, W. F. & GUTKIND, J. S. (1994). Ras-dependent activation of MAP kinase pathway mediated by C-protein βγ subunits. Nature 369, 418-420.
30. DAAKA, Y., LUTTRELL, L. M., AHN, S., DELLA ROCCA, G. J., FERGUSON, S. S., CARON, M. G. & LEFKOWITZ, R. J. (1998). Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. Journal of Biological Chemistry 273, 685-688.
31. DAAKA, Y., PITCHER, J. A., RICHARDSON, M., STOFFEL, R. H., ROBISHAW, J. D. & LEFKOWITZ, R. J. (1897). Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the USA 94, 2180-2185.
32. DAMKE, H., BABA, T., WARNOCK, D. E. & SCHMID, S. L. (1994). Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. Journal of Cell Biology 127, 915-934.
33. DAWSON, T. M., ARRIZA, J. L., JAWORSKY, D. E., BORISY, F. F., ATTRAMADAL, H., LEFKOWITZ, R. J. & RONNETT, G. V. (1993). β-Adrenergic receptor kinase-2 and β-arrestin-2 as mediators of odorant-induced desensitization. Science 259, 825-829.
34. DEBBURMAN, S. K., KUNAPULI, P., BENOVIC, J. L. & HOSEY, M. M. (1995a). Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Molecular Pharmacology 47, 224-233.
35. DEBBURMAN, S. K., PTASIENSKI, J., BENOVIC, J. L. & HOSEY, M. M. (1996). G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein βγ subunits. Journal of Biological Chemistry 271, 22552-22562.
36. DEBBURMAN, S. K., PTASIENSKI, J., BOETTICHER, E., LOMASNEY, J. W., BENOVIC, J. L. & HOSEY, M. M. (1995b). Lipid-mediated regulation of G protein-coupled receptor kinases 2 and 3. Journal of Biological Chemistry 270, 5742-5747.
37. i in caveolae in DDT1 MF-2 smooth muscle cells. Journal of Biological Chemistry 272, 17858-17866.
38. 1B-adrenergic receptor. Journal of Biological Chemistry 272, 28712-28719.
39. 1B-adrenergic receptor. Journal of Biological Chemistry 271, 5049-5058.
40. DRAZNER, M. H., PEPPEL, K. C., DYER, S., GRANT, A. O., KOCH, W. J. & LEFKOWITZ, R. J. (1997). Potentiation of β-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. Journal of Clinical Investigation 99, 288-296.
41. FERGUSON, S. S., DOWNEY, W. E. III, COLAPIETRO, A. M., BARAK, L. S., MENARD, L. & CARON, M. G. (1996). Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271, 363-366.
42. FRANCI, C., GOSLING, J., TSOU, C. L., COUGHLIN, S. R. & CHARO, I. F. (1996). Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. Journal of Immunology 157, 5606-5612.
43. 2-adrenergic receptor. Journal of Biological Chemistry 271, 13796-13803.
44. FREEDMAN, N. J., AMENT, A. S., OPPERMANN, M., STOFFEL, R. H., EXUM, S. T. & LEFKOWITZ, R. J. (1997). Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. Journal of Biological Chemistry 272, 17734-17743.
45. FREEDMAN, N. J. & LEFKOWITZ, R. J. (1996). Desensitization of G protein-coupled receptors. Recent Progress in Hormone Research 51, 319-351; discussion, pp. 352-353.
46. 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Journal of Biological Chemistry 270, 17953-17961.
47. FREEMAN, J. L., DE LA CRUZ, E. M., POLLARD, T. D., LEFKOWITZ, R. J. & PITCHER, J. A. (1998). Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. Journal of Biological Chemistry 273, 20653-20657.
48. 2-adrenergic receptor. Journal of Biological Chemistry 273, 6976-6981.
49. GETHER, U. & KOBILKA, B. K. (1998). G protein-coupled receptors. II. Mechanism of agonist activation. Journal of Biological Chemistry 273, 17979-17982.
50. 2-adrenergic receptor. Nature 383, 447-450.
51. GRAY-KELLER, M. P., POLANS, A. S., PALCZEWSKI, K. & DETWILER, P. B. (1993). The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron 10, 523-531.
52. HAGA, K., KAMEYAMA, K., HAGA, T., KIKKAWA, U., SHIOZAKI, K. & UCHIYAMA, H. (1996). Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C. Journal of Biological Chemistry 271, 2776-2782.
53. HAGA, K., OGAWA, H., HAGA, T. & MUROFUSHI, H. (1998). GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin. European Journal of Biochemistry 255, 363-368.
54. HAMM, H. E. (1998). The many faces of G protein signaling. Journal of Biological Chemistry 273, 669-672.
55. HASBI, A., POLASTRON, J., ALLOUCHE, S., STANASILA, L., MASSOTTE, D. & JAUZAC, P. (1998). Desensitization of the delta-opioid receptor correlates with its phosphorylation in SK-N-BE cells: involvement of a G protein-coupled receptor kinase. Journal of Neurochemistry 70, 2129-2138.
56. 2-adrenergic receptor. Symposia of the Society for Experimental Biology 44, 225-240.
57. HENLEY, J R., KRUEGER, E. W., OSWALD, B. J. & MCNIVEN, M. A. (1998). Dynamin-mediated internalization of caveolae. Journal of Cell Biology 141, 85-99.
58. HIPKIN, R. W., SANCHEZ-YAGUE, J. & ASCOLI, M. (1993). Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin receptor expressed in a stably transfected cell line. Molecular Endocrinology 7, 823-832.
59. HIPKIN, R. W., WANG, Z. & ASCOLI, M. (1995). Human chorionic gonadotropin (CG)- and phorbol ester-stimulated phosphorylation of the luteinizing hormone/CG receptor maps to serines 635, 639, 649, and 652 in the C-terminal cytoplasmic tail. Molecular Endocrinology 9, 151-158.
60. HSU, M. H., CHIANG, S. C., YE, R. D. & PROSSNITZ, E. R. (1997). Phosphorylation of the N-formyl peptide receptor is required for receptor internalization but not chemotaxis. Journal of Biological Chemistry 272, 29426-29429.
61. IACCARINO, G., ROCKMAN, H. A., SHOTWELL, K. F., TOMHAVE, E. D. & KOCH, W. J. (1998a). Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. American Journal of Physiology 275, H1298-1306.
62. IACCARINO, G., TOMHAVE, E. D., LEFKOWITZ, R. J. & KOCH, W. J. (1998b). Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade. Circulation 98, 1783-1789.
63. IACOVELLI, L., FRANCHETTI, R., MASINI, M. & DE BLASI, A. (1996). GRK2 and β-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response. Molecular Endocrinology 10, 1138-1146.
64. INGLESE, J., KOCH, W. J., CARON, M. G. & LEFKOWITZ, R. J. (1992). Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature 359, 147-150.
65. INGLESE, J., LUTTRELL, L. M., INIGUEZ-LLUHI, J. A., TOUHARA, K., KOCH, W. J. & LEFKOWITZ, R. J. (1994). Functionally active targeting domain of the β-adrenergic receptor kinase: an inhibitor of Gβγ-mediated stimulation of type II adenylyl cyclase. Proceedings of the National Academy of Sciences of the USA 91, 3637-3641.
66. INNAMORATI, G., SADEGHI, H. & BIRNBAUMER, M. (1998a). Transient phosphorylation of the Via vasopressin receptor. Journal of Biological Chemistry 273, 7155-7161.
67. INNAMORATI, G., SADEGHI, H., EBERLE, A. N. & BIRNBAUMER, M. (1997). Phosphorylation of the V2 vasopressin receptor. Journal of Biological Chemistry 272, 2486-2492.
68. INNAMORATI, G., SADEGHI, H. M., TRAN, N. T. & BIRNBAUMER, M. (1998b). A serine cluster prevents recycling of the V2 vasopressin receptor. Proceedings of the National Academy of Sciences of the USA 95, 2222-2226.
69. ISHII, I., SAITO, E., IZUMI, T., UI, M. & SHIMIZU, T. (1998). Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process. Journal of Biological Chemistry 273, 9878-9885.
70. ISHII, K., CHEN, J., ISHII, M., KOCH, W. J., FREEDMAN, N. J., LEFKOWITZ, R. J. & COUGHLIN, S. R. (1994). Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Journal of Biological Chemistry 269, 1125-1130.
71. ISHIZAKA, N., ALEXANDER, R. W., LAURSEN, J. B., KAI, H., FUKUI, T., OPPERMANN, M., LEFKOWITZ, R. J., LYONS, P. R. & GRIENDLING, K. K. (1997). G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. Journal of Biological Chemistry 272, 32482-32488.
72. JABER, M., KOCH, W. J., ROCKMAN, H., SMITH, B., BOND, R. A., SULIK, K. K., ROSS, J. JR, LEFKOWITZ, R. J., CARON, M. G. & GIROS, B. (1996). Essential role of β-adrenergic receptor kinase 1 in cardiac development and function. Proceedings of the National Academy of Sciences of the USA 93, 12974-12979.
73. 2-Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. Journal of Biological Chemistry 272, 23871-23879.
74. KHANI, S. C., NIELSEN, L. & VOGT, T. M. (1998). Biochemical evidence for pathogenicity of rhodopsin kinase mutations correlated with the Oguchi form of congenital stationary night blindness. Proceedings of the National Academy of Sciences of the USA 95, 2824-2827.
75. KOCH, W. J., INGLESE, J., STONE, W. C. & LEFKOWITZ, R. J. (1993). The binding site for the βγ subunits of heterotrimeric G proteins on the β-adrenergic receptor kinase. Journal of Biological Chemistry 268, 8250-8260.
76. KOCH, W. J., ROCKMAN, H. A., SAMAMA, P., HAMILTON, R. A., BOND, R. A., MILANO, C. A. & LEFKOWITZ, R. J. (1995). Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science 268, 1350-1353.
77. 2-adrenergic receptor. Journal of Biological Chemistry 269, 13084-13087.
78. KOVOOR, A., CELVER, J. P., WU, A. & CHAVKIN, C. (1998). Agonist induced homologous desensitization of μ-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Molecular Pharmacology 54, 704-711.
79. 2-adrenergic receptor dephosphorylation by vesicular acidification. Journal of Biological Chemistry 272, 5-8.
80. KRUPNICK, J. G. & BENOVIC, J. L. (1998). The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annual Review of Pharmacology and Toxicology 38, 289-319.
81. KRUPNICK, J. G., SANTINI, F., GAGNON, A. W., KEEN, J. H. & BENOVIC, J. L. (1997). Modulation of the arrestin-clathrin interaction in cells. Characterization of β-arrestin dominant-negative mutants. Journal of Biological Chemistry 272, 32507-32512.
82. KUHN, H. (1974). Light-dependent phosphorylation of rhodopsin in living frogs. Nature 250, 588-590.
83. KUNAPULI, P., GUREVICH, V. V. & BENOVIC, J. L. (1994a). Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. Journal of Biological Chemistry 269, 10209-10212.
84. KUNAPULI, P., ONORATO, J. J., HOSEY, M. M. & BENOVIC, J. L. (1994b). Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. Journal of Biological Chemistry 269, 1099-1105.
85. KWATRA, M. M., BENOVIC, J. L., CARON, M. G., LEFKOWITZ, R. J. & HOSEY, M. M. (1989a). Phosphorylation of chick heart muscarinic cholinergic receptors by the β-adrenergic receptor kinase. Biochemistry 28, 4543-4547.
86. KWATRA, M. M. & HOSEY, M. M. (1986). Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist. Journal of Biological Chemistry 261, 12429-12432.
87. KWATRA, M. M., LEUNG, E., MAAN, A. C., MCMAHON, K. K., PTASIENSKI, J., GREEN, R. D. & HOSEY, M. M. (1987). Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization. Journal of Biological Chemistry 262, 16314-16321.
88. KWATRA, M. M., PTASIENSKI, J. & HOSEY, M. M. (1989b). The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor. Molecular Pharmacology 35, 553-558.
89. q/11, is a substrate of β-adrenergic receptor kinase 1 and 2. Journal of Biological Chemistry 268, 9161-9164.
90. 1B-adrenergic receptor. Journal of Biological Chemistry 269, 22887-22893.
91. LAZARI, M. F., BERTRAND, J. E., NAKAMURA, K., LIU, X., KRUPNICK, J. G., BENOVIC, J. L. & ASCOLI, M. (1998). Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization. Journal of Biological Chemistry 273, 18316-18324.
92. LEE, K. B., PALS-RYLAARSDAM, R., BENOVIC, J. L. & HOSEY, M. M. (1998). Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors. Journal of Biological Chemistry 273, 12967-12972.
93. LEFKOWITZ, R. J. (1998). G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. Journal of Biological Chemistry 273, 18677-18680.
94. LEURS, R., SMIT, M. J., ALEWIJNSE, A. E. & TIMMERMAN, H. (1998). Agonist-independent regulation of constitutively active G-protein-coupled receptors. Trends in Biochemical Sciences 23, 418-422.
95. 2+-binding proteins on G protein-coupled receptor kinases. Biochemistry 37, 13650-13659.
96. 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. Journal of Biological Chemistry 267, 4740-4746.
97. 2-adrenergic receptor and rhodopsin systems. Journal of Biological Chemistry 267, 8558-8564.
98. LOUDON, R. P. & BENOVIC, J. L. (1994). Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. Journal of Biological Chemistry 269, 22691-22697.
99. LOUDON, R. P. & BENOVIC, J. L. (1997). Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. Journal of Biological Chemistry 272, 27422-27427.
100. q/11, G-protein receptor kinase-2/3, and β-arrestin-1/2. Molecular Biology of the Cell 9, 2305-2324.
101. MENARD, L., FERGUSON, S. S., BARAK, L. S., BERTRAND, L., PREMONT, R. T., COLAPIETRO, A. M., LEFKOWITZ, R. J. & CARON, M. G. (1996). Members of the G protein-coupled receptor kinase family that phosphorylate the β2-adrenergic receptor facilitate sequestration. Biochemistry 35, 4155-4160.
102. MUNDELL, S. J., BENOVIC, J. L. & KELLY, E. (1997). A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization. Molecular Pharmacology 51, 991-998.
103. MUNDELL, S. J., LUTY, J. S., WILLETS, J., BENOVIC, J. L. & KELLY, E. (1998). Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization. British Journal of Pharmacology 125, 347-356.
104. MURGA, C., PENELA, P., ZAFRA, F. & MAYOR, F. JR (1998). The subcellular and cellular distribution of G protein-coupled receptor kinase 2 in rat brain. Neuroscience 87, 631-637.
105. MURRAY, S. R., EVANS, C. J. & VON ZASTROW, M. (1998). Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor. Journal of Biological Chemistry 273, 24987-24991.
106. NAGAYAMA, Y., TANAKA, K., NAMBA, H., YAMASHITA, S. & NIWA, M. (1996). Expression and regulation of G protein-coupled receptor kinase 5 and β-arrestin-1 in rat thyroid FRTL5 cells. Thyroid 6, 627-631.
107. NAKAMURA, K., KRUPNICK, J. G., BENOVIC, J. L. & ASCOLI, M. (1998). Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal an activation- and phosphorylation-independent but arrestin-dependent pathway for internalization. Journal of Biological Chemistry 273, 24346-24354.
108. NEILL, J. D., DUCK, L. W., MUSGROVE, L. C. & SELLERS, J. C. (1998). Potential regulatory roles for G protein-coupled receptor kinases and β-arrestins in gonadotropin-releasing hormone receptor signaling. Endocrinology 139, 1781-1788.
109. NG, G. Y., MOUILLAC, B., GEORGE, S. R., CARON, M., DENNIS, M., BOUVIER, M. & O'DOWD, B. F. (1994). Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor. European Journal of Pharmacolgy 267, 7-19.
110. NISHIMURA, K., WARABI, K., ROUSH, E. D., FREDERICK, J., SCHWINN, D. A. & KWATRA, M. M. (1998). Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes. Biochemistry 37, 1192-1198.
111. OH, P., MCINTOSH, D. P. & SCHNITZER, J. E. (1998). Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium. Journal of Cell Biology 141, 101-114.
112. ONORATO, J. J., GILLIS, M. E., LIU, Y., BENOVIC, J. L. & RUOHO, A. E. (1995). The β-adrenergic receptor kinase (GRK2) is regulated by phospholipids. Journal of Biological Chemistry 270, 21346-21353.
113. OPPERMANN, M., FREEDMAN, N. J., ALEXANDER, R. W. & LEFKOWITZ, R. J. (1996). Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. Journal of Biological Chemistry 271, 13266-13272.
114. OTTO-BRUC, A. E., FARISS, R. N., VAN HOOSER, J. P. & PALCZEWSKI, K. (1998). Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by α-toxin. Proceedings of the National Academy of Sciences of the USA 95, 15014-15019.
115. PALCZEWSKI, K. (1997). GTP-binding-protein-coupled receptor kinases - two mechanistic models. European Journal of Biochemistry 248, 261-269.
116. PALMER, T. M., BENOVIC, J. L. & STILES, G. L. (1995). Agonist-dependent phosphorylation and desensitization of the rat A3 adenosine receptor. Evidence for a G-protein-coupled receptor kinase-mediated mechanism. Journal of Biological Chemistry 270, 29607-29613.
117. PALMER, T. M. & STILES, G. L. (1997). Identification of an A2a adenosine receptor domain specifically responsible for mediating short-term desensitization. Biochemistry 36, 832-838.
118. PALS-RYLAARSDAM, R., GUREVICH, V. V., LEE, K. B., PTASIENSKI, J. A., BENOVIC, J. L. & HOSEY, M. M. (1997). Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways. Journal of Biological Chemistry 272, 23682-23089.
119. PALS-RYLAARSDAM, R. & HOSEY, M. M. (1997). Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor. Journal of Biological Chemistry 272, 14152-14158.
120. PALS-RYLAARSDAM, R., XU, Y., WITT-ENDERBY, P., BENOVIC, J. L. & HOSEY, M. M. (1995). Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. Journal of Biological Chemistry 270, 29004-29011.
121. PEI, G., KIEFFER, B. L., LEFKOWITZ, R. J. & FREEDMAN, N. J. (1995). Agonist-dependent phosphorylation of the mouse δ-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. Molecular Pharmacology 48, 173-177.
122. PEI, G., TIBERI, M., CARON, M. G. & LEFKOWITZ, R. J. (1994). An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by Gβγ subunits. Proceedings of the National Academy of Sciences of the USA 91, 3633-3636.
123. PEPPEL, K., BOEKHOFF, I., MCDONALD, P., BREER, H., CARON, M. G. & LEFKOWITZ, R. J. (1997). G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. Journal of Biological Chemistry 272, 25425-25428.
124. 2 binding site distinguishes the GRK subfamilies. Journal of Biological Chemistry 271, 24907-24913.
125. PITCHER, J. A., FREEDMAN, N. J. & LEFKOWITZ, R. J. (1998a). G protein-coupled receptor kinases. Annual Review of Biochemistry 67, 653-692.
126. PITCHER, J. A., HALL, R. A., DAAKA, Y., ZHANG, J., FERGUSON, S. S., HESTER, S., MILLER, S., CARON, M. G., LEFKOWITZ, R. J. & BARAK, L. S. (1998b). The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. Journal of Biological Chemistry 273, 12316-12324.
127. PITCHER, J. A., INGLESE, J., HIGGINS, J. B., ARRIZA, J. L., CASEY, P. J., KIM, C., BENOVIC, J. L., KWATRA, M. M., CARON, M. G. & LEFKOWITZ, R. J. (1992). Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science 257, 1264-1267.
128. PITCHER, J. A., PAYNE, E. S., CSORTOS, C., DEPAOLI-ROACH, A. A. & LEFKOWITZ, R. J. (1995). The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proceedings of the National Academy of Sciences of the USA 92, 8343-8347.
129. 2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proceedings of the National Academy of Sciences of the USA 95, 14082-14087.
130. PREMONT, R. T., INGLESE, J. & LEFKOWITZ, R. J. (1995). Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB Journal 9, 175-182.
131. PREMONT, R. T., MACRAE, A. D., STOFFEL, R. H., CHUNG, N., PITCHER, J. A., AMBROSE, C., INGLESE, J., MACDONALD, M. E. & LEFKOWITZ, R. J. (1996). Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. Journal of Biological Chemistry 271, 6403-6410.
132. PRONIN, A. N. & BENOVIC, J. L. (1997). Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. Journal of Biological Chemistry 272, 3806-3812.
133. PRONIN, A. N., SATPAEV, D. K., SLEPAK, V. Z. & BENOVIC, J. L. (1997). Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain. Journal of Biological Chemistry 272, 18273-18280.
134. PROSSNITZ, E. R. (1997). Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation. Journal of Biological Chemistry 272, 15213-15219.
135. PROSSNITZ, E. R., KIM, C. M., BENOVIC, J. L. & YE, R. D. (1995). Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. Journal of Biological Chemistry 270, 1130-1137.
136. QUINTANA, J., HIPKIN, R. W., SANCHEZ-YAGUE, J. & ASCOLI, M. (1994). Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells. Journal of Biological Chemistry 269, 8772-8779.
137. RAMKUMAR, V., KWATRA, M., BENOVIC, J. L., STILES, G. L. & STILESA, G. L. (1993). Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase Biochimica et Biophysica Acta 1179, 89-97 (with erratum in Biochimica et Biophysica Acta 1220, 229).
138. RICHARDSON, R. M. & HOSEY, M. M. (1992). Agonist-induced phosphorylation and desensitization of human m2 muscarinic cholinergic receptors in Sf9 insect cells. Journal of Biological Chemistry 267, 22249-22255.
139. RICHARDSON, R. M., KIM, C., BENOVIC, J. L. & HOSEY, M. M. (1993).
140. ROCKMAN, H. A., CHIEN, K. R., CHOI, D. J., IACCARINO, G., HUNTER, J. J., ROSS, J. JR, LEFKOWITZ, R. J. & KOCH, W. J. (1998a). Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the USA 95, 7000-7005.
141. ROCKMAN, H. A., CHOI, D. J., AKHTER, S. A., JABER, M., GIROS, B., LEFKOWITZ, R. J., CARON, M. G. & KOCH, W. J. (1998b). Control of myocardial contractile function by the level of β-adrenergic receptor kinase 1 in gene-targeted mice. Journal of Biological Chemistry 273, 18180-18184.
142. ROCKMAN, H. A., CHOI, D. J., RAHMAN, N. U., AKHTER, S. A., LEFKOWITZ, R. J. & KOCH, W. J. (1996). Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proceedings of the National Academy of Sciences of the USA 93, 9954-9959.
143. ROTH, N. S., CAMPBELL, P. T., CARON, M. G., LEFKOWITZ, R. J. & LOHSE, M. J. (1991). Comparative rates of desensitization of β-adrenergic receptors by the β-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the USA 88, 6201-6204.
144. SCHLADOR, M. L. & NATHANSON, N. M. (1997). Synergistic regulation of m2 muscarinic acetylcholine receptor desensitization and sequestration by G protein-coupled receptor kinase-2 and β-arrestin-1. Journal of Biological Chemistry 272, 18882-18890.
145. SCHLEICHER, S., BOEKHOFF, I., ARRIZA, J., LEFKOWITZ, R. J. & BREER, H. (1993). A β-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. Proceedings of the National Academy of Sciences of the USA 90, 1420-1424.
146. + current in rat atrial cells. Journal of Physiology 487, 359-366.
147. + channels expressed in Chinese hamster ovary cells. Journal of Physiology 507, 325-334.
148. SIBLEY, D. R., STRASSER, R. H., BENOVIC, J. L., DANIEL, K. & LEFKOWITZ, R. J. (1986). Phosphorylation/dephosphorylation of the β-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proceedings of the National Academy of Sciences of the USA 83, 9408-9412.
149. STRASSER, R. H., SIBLEY, D. R. & LEFKOWITZ, R. J. (1986). A novel catecholamine-activated adenosine cyclic 3′,5′-phosphate independent pathway for β-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. Biochemistry 25, 1371-1377.
150. TAKANO, T., HONDA, Z., SAKANAKA, C., IZUMI, T., KAMEYAMA, K., HAGA, K., HAGA, T., KUROKAWA, K. & SHIMIZU, T. (1994). Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization. Journal of Biological Chemistry 269, 22453-22458.
151. TIBERI, M., NASH, S. R., BERTRAND, L., LEFKOWITZ, R. J. & CARON, M. G. (1996). Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. Journal of Biological Chemistry 271, 3771-3778.
152. TOBIN, A. B., WILLARS, G. B., BURFORD, N. T. & NAHORSKI, S. R. (1995). Relationship between agonist binding, phosphorylation and immunoprecipitation of the m3-muscarinic receptor, and second messenger responses. British Journal of Pharmacology 116, 1723-1728.
153. TSUGA, H., KAMEYAMA, K. & HAGA, T. (1998a), Desensitization of human muscarinic acetylcholine receptor m2 subtypes is caused by their sequestration/internalization. Journal of Biochemistry 124, 863-868.
154. TSUGA, H., KAMEYAMA, K., HAGA, T., HONMA, T., LAMEH, J. & SADEE, W. (1998b). Internalization and downregulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intra-cellular m2 loop and G protein-coupled receptor kinase 2. Journal of Biological Chemistry 273, 5323-5330.
155. TSUGA, H., KAMEYAMA, K., HAGA, T., KUROSE, H. & NAGAO, T. (1994). Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2. Journal of Biological Chemistry 269, 32522-32527.
156. TSUGA, H., OKUNO, E., KAMEYAMA, K. & HAGA, T. (1998c). Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6. Journal of Pharmacology and Experimental Therapeutics 284, 1218-1226.
157. 1-adrenergic receptors in the failing human heart. Circulation 87, 454-463.
158. UNGERER, M., KESSEBOHM, K., KRONSBEIN, K., LOHSE, M. J. & RICHARDT, G. (1996). Activation of β-adrenergic receptor kinase during myocardial ischemia. Circulation Research 79, 455-460.
159. UNGERER, M., PARRUTI, G., BOHM, M., PUZICHA, M., DEBLASI, A., ERDMANN, E. & LOHSE, M. J. (1994). Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart. Circulation Research 74, 206-213.
160. URRUTIA, R., HENLEY, J. R., COOK, T. & MCNIVEN, M. A. (1997). The dynamins: redundant or distinct functions for an expanding family of related GTPases? Proceedings of the National Academy of Sciences of the USA 94, 377-384.
161. VAN DER BLIEK, A. M., REDELMEIER, T. E., DAMKE, H., TISDALE, E. J., MEYEROWITZ, E. M. & SCHMID, S. L. (1993). Mutations in human dynamin block an intermediate stage in coated vesicle formation. Journal of Cell Biology 122, 553-563.
162. VICKERY, R. G. & VON ZASTROW, M. (1999). Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. Journal of Cell Biology 144, 31-43.
163. VIRLON, B., FIRSOV, D., CHEVAL, L., REITER, E., TROISPOUX, C., GUILLOU, F. & ELALOUF, J. M. (1998). Rat G protein-coupled receptor kinase GRK4: identification, functional expression, and differential tissue distribution of two splice variants. Endocrinology 139, 2784-2795.
164. VOGLER, O., BOOATKEWITSCH, G. S., WRISKE, C., KRUMMENERL, P., JAKOBS, K. H. & VAN KOPPEN, C. J. (1998). Receptor subtype-specific regulation of muscarinic acetylcholine receptor sequestration by dynamin. Distinct sequestration of m2 receptors. Journal of Biological Chemistry 273, 12155-12160.
165. VOURET-CRAVIARI, V., AUBERGER, P., POUYSSEGUR, J. & VAN OBBERGHEN-SCHILLING, E. (1995). Distinct mechanisms regulate 5-HT2 and thrombin receptor desensitization. Journal of Biological Chemistry 270, 4813-4821.
166. WANG, Z., LIU, X. & ASCOLI, M. (1997). Phosphorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormone. Molecular Endocrinology 11, 183-192.
167. WELLER, M., VIRMAUX, N. & MANDEL, P. (1975). Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin. Proceedings of the National Academy of Sciences of the USA 72, 381-385.
168. WHISTLER, J. L. & VON ZASTROW, M. (1998). Morphine-activated opioid receptors elude desensitization by β-arrestin. Proceedings of the National Academy of Sciences of the USA 95, 9914-9919.
169. YAMADA, M., INANOBE, A. & KURACHI, Y. (1998). G protein regulation of potassium ion channels. Pharmacological Reviews 50, 723-760.
170. YAMAMOTO, S., SIPPEL, K. C., BERSON, E. L. & DRYJA, T. P. (1997). Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nature Genetics 15, 175-178.
171. YU, Y., ZHANG, L., YIN, X., SUN, H., UHL, G. R. & WANG, J. B. (1997). μ-Opioid receptor phosphorylation, desensitization, and ligand efficacy. Journal of Biological Chemistry 272, 28869-28874.
172. ZERANGUE, N. & JAN, L. Y. (1998). G-protein signaling: fine-tuning signaling kinetics. Current Biology 8, R313-316.
173. 2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. Journal of Biological Chemistry 272, 27005-27014.
174. ZHANG, J., FERGUSON, S. S., BARAK, L. S., BODDULURI, S. R., LAPORTE, S. A., LAW, P. Y. & CARON, M. G. (1998). Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness. Proceedings of the National Academy of Sciences of the USA 95, 7157-7162.
175. ZHANG, J., FERGUSON, S. S. G., BARAK, L. S., MENARD, L. & CARON, M. G. (1996a). Dynamin and β-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. Journal of Biological Chemistry 271, 18302-18305.
176. ZHANG, L., YU, Y., MACKIN, S., WEIGHT, F. F., UHL, G. R. & WANG, J. B. (1996b). Differential μ opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. Journal of Biological Chemistry 271, 11449-11454.
177. ZHAO, X., HUANG, J., KHANI, S. C. & PALCZEWSKI, K. (1998). Molecular forms of human rhodopsin kinase (GRK1). Journal of Biological Chemistry 273, 5124-5131.
178. ZHAO, X., PALCZEWSKI, K. & OHGURO, H. (1995). Mechanism of rhodopsin phosphorylation. Biophysical Chemistry 56, 183-188.