Modulation of 5-HT(1A) receptor signalling by point-mutation of cysteine351 in the rat G(αo) protein

Neuropharmacology

Volumn 38, Issue 7, 1999, Pages 1035-1041

  Dupuis, Delphine S ^a   Tardif, Stéphanie ^a   Wurch, Thierry ^a   Colpaert, Francis C ^a   Pauwels, Petrus J ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

35S GTP S binding response; Fusion protein; Intrinsic activity; Partial agonist; Recombinant human 5 HT(1A) receptor and rat G( o) protein

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BUSPIRONE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; IPSAPIRONE; MUTANT PROTEIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RECEPTOR PROTEIN; RECEPTOR SUBTYPE; SEROTONIN 1A RECEPTOR; UNCOUPLING PROTEIN; CYSTEINE; GNAS PROTEIN, HUMAN; GNAS PROTEIN, RAT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NERVE PROTEIN; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SULFUR;

ARTICLE; HUMAN; HUMAN CELL; MODULATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR DENSITY; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; CELL STRAIN COS1; GENETICS; METABOLISM; RAT;

ANIMALS; BRAIN; COS CELLS; CYSTEINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; NERVE TISSUE PROTEINS; POINT MUTATION; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SULFUR RADIOISOTOPES;

EID: 0032586872     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00033-7     Document Type: Article

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