Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63

Cellular Signalling

Volumn 15, Issue 4, 2003, Pages 435-446

  Niedernberg, Anke ^a   Tunaru, Sorin ^b   Blaukat, Andree ^b   Ardati, Ali ^c   Kostenis, Evi ^a,d,e  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c SANOFI   (France)

^d 7TM Pharma A S   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Dioleoylphosphatidic acid; GPR63; Intracellular Ca2+; Lysophosphatidic acid; Proliferation; Sphingosine 1 phosphate

Indexed keywords

AEQUORIN; CALCIUM ION; CHIMERIC PROTEIN; DIOLEOYLPHOSPHATIDIC ACID; GPR63 RECEPTOR; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; PERTUSSIS TOXIN; PHOSPHOLIPID; RECEPTOR; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; BIOLUMINESCENCE; BRAIN; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CAUDATE NUCLEUS; CELL PROLIFERATION; CHO CELL; CONTROLLED STUDY; DEVICE; DRUG EFFECT; DRUG MECHANISM; FLUOROMETRIC IMAGING PLATE READER; FLUOROMETRY; HEART; HUMAN; HUMAN CELL; IMAGING; KIDNEY; LIPID ANALYSIS; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; SPLEEN; STOMACH; THALAMUS; THYMUS;

AEQUORIN; ANIMALS; CALCIUM SIGNALING; CHO CELLS; CRICETINAE; GENE EXPRESSION; GTP-BINDING PROTEINS; HUMANS; LYSOPHOSPHOLIPIDS; PHOSPHATIDIC ACIDS; RECEPTORS, CELL SURFACE; SPHINGOSINE; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 12244280857     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(02)00119-5     Document Type: Article

References (45)

1. Jalink K., Hordijk P.L., Moolenaar W.H. Biochim. Biophys. Acta. 1198:1994;185-196.
2. Siess W., Zangl K.J., Essler M., Bauer M., Brandl R., Corrinth C.et al. Proc. Natl. Acad. Sci. U. S. A. 96:1999;6931-6936.
3. Tokumura A., Fukuzawa K., Yamada S., Tsukatani H. Arch. Int. Pharmacodyn. Ther. 245:1980;74-83.
4. Tokumura A., Yotsumoto T., Masuda Y., Tanaka S. Res. Commun. Mol. Pathol. Pharmacol. 90:1995;96-102.
5. Jalink K., Moolenaar W.H., van Dujin B. Proc. Natl. Acad. Sci. U. S. A. 90:1993;1857-1861.
6. Lee M.J., Thangada S., Claffey K.P., Ancellin N., Liu C.H., Kluk M.et al. Cell. 99:1999;301-312.
7. Rizza C., Leitinger N., Yue J., Fischr D.J., Wang D., Shih P.T.et al. Lab. Invest. 79:1999;1227-1235.
8. Schulze C., Smales C., Rubin L.L., Staddon J.M. J. Neurochem. 68:1997;991-1000.
9. Gohla A., Harhammer R., Schultz G. J. Biol. Chem. 273:1998;4653-4659.
10. Cremers B., Flesch M., Kostenis E., Maack C., Niedernberg A., Stoff A.et al. J. Mol. Cell. Cardiol. 2002;. [in press].
11. Fukushima N., Chun J. Prostaglandins. 64:2001;21-32.
12. Guo Z., Liliom K., Fischer D.J., Bathurst I.C., Tomei L.D., Kiefer M.C.et al. Proc. Natl. Acad. Sci. U. S. A. 93:1996;14367-14372.
13. Kawasawa Y., Kume K., Izumi T., Shimizu T. Biochem. Biophys. Res. Commun. 276:2000;957-964.
14. Erickson J.R., Wu J.J., Goddard J.G., Tigyi G., Kawanishi K., Tomei L.D.et al. J. Biol. Chem. 273:1998;1506-1510.
15. Pyne S., Pyne N. Pharmacol. Ther. 88:2000;115-131.
16. Kostenis E. J. Recept. Signal Transduct. Res. 22:2002;269-283.
17. Niedernberg A., Scherer C.R., Busch A.E., Kostenis E. Biochem. Pharmacol. 7402:2002;1-8.
18. Baubet V., Le Mouellic H., Campbell A.K., Fossier P., Brulet P. Proc. Natl. Acad. Sci. 97:2000;7260-7265.
19. Conklin B.R., Farfel Z., Lustig K.D., Julius D., Bourne H.R. Nature. 363:1993;274-276.
20. Kostenis E. TIPS. 22:2001;560-564.
21. Alderton F., Sambi B., Tate R., Pyne N.J., Pyne S. Br. J. Pharmacol. 134:2001;6-9.
22. Xing H., Tran H.C., Kanpp T.E., Negulescu P.A., Pollok B.A. J. Recept. Signal Transduct. Res. 4:2000;189-210.
23. Parnot C., Bardin S., Miserey-Lenkei S., Guedin D., Corvol P., Clauser E. Proc. Natl. Acad. Sci. U. S. A. 97:2002;7615-7620.
24. Kotani M., Mollereau C., Detheux M., Le Poul E., Brezillon S., Vakili J.et al. Br. J. Pharmacol. 133:2001;138-144.
25. Le Poul E., Hisada S., Mizuguchi Y., Dupriez V.J., Burgeon E., Detheux M. J. Biomol. Screen. 7:2002;57-65.
26. An S., Zheng Y., Bleu T. J. Biol. Chem. 275:2000;288-296.
27. Wang F., Van Brocklyn J.R., Hobson J.P., Movafagh S., Zukowska-Grojec Z., Milstien S.et al. J. Biol. Chem. 274:1999;35343-35350.
28. Kimura T., Watanabe T., Sato K., Kon J., Tomura H., Tamama K.et al. Biochem. J. 348:2000;71-76.
29. Malek R.L., Toman R.E., Edsall L.C., Wong S., Chiu J., Letterle C.A.et al. J. Biol. Chem. 23:2001;5692-5699.
30. Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M.et al. Brain Res. Mol. Brain Res. 86:2001;13-22.
31. Kluk M.J., Hla T. Circ. Res. 8:2001;496-502.
32. Tamama K.-I., Kon J., Sato K., Tomura H., Kuwabara A., Kimura T.et al. Biochem. J. 353:2001;139-146.
33. Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T. Biochem. Biophys. Res. Commun. 276:2000;952-956.
34. Fukushima N., Ishii I., Contos J.J.A., Weinwer J.A., Chun J. Annu. Rev. Pharmacol. Toxicol. 41:2001;507-534.
35. Yatomi Y., Igarashi Y., Yang L. J. Biochem. 121:1997;969-973.
36. Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G.et al. Science. 291:2001;1800-1803.
37. Rodriguez de Fonseca F., Navarro M., Gomez R., Escuredo L., Nava F., Fu J.et al. Nature. 414:2001;209-212.
38. Devane W.A. Science. 258:1992;1946-1949.
39. Litosch I. Cell. Signal. 14:2002;259-263.
40. Spiegel S., English D., Milstien S. Trends Cell Biol. 12:2002;236-242.
41. Rizzo M.A., Romero G. Pharmacol. Ther. 94:2002;35-50.
42. Hisano N., Yatomi Y., Satoh K., Akimoto S., Mitsumata M., Fujino M.A.et al. Blood. 93:1999;4293-4299.
43. Kimura Y., Schmitt A., Fukushima N., Ishii I., Kimura H., Nebreda A.R.et al. J. Biol. Chem. 276:2001;15208-15215.
44. Wang D.A., Lorincz Z., Bautista D.L., Liliom K., Tigyi G., Parrill A.L. J. Biol. Chem. 276:2001;49213-49220.
45. Parrill A.L., Wang D., Bautista D.L., Van Brocklyn J.R., Lorincz Z., Fischer D.J.et al. J. Biol. Chem. 275:2000;39379-39384.